2013
DOI: 10.1155/2013/316250
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Improving the Efficacy of Conventional Therapy by Adding Andrographolide Sulfonate in the Treatment of Severe Hand, Foot, and Mouth Disease: A Randomized Controlled Trial

Abstract: Background. Herb-derived compound andrographolide sulfonate (called Xiyanping injection) recommended control measure for severe hand, foot, and mouth disease (HFMD) by the Ministry of Health (China) during the 2010 epidemic. However, there is a lack of good quality evidence directly comparing the efficacy of Andrographolide Sulfonate combination therapy with conventional therapy. Methods. 230 patients were randomly assigned to 7–10 days of Andrographolide Sulfonate 5–10 mg/Kg/day and conventional therapy, or c… Show more

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Cited by 19 publications
(27 citation statements)
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“…18 It has an effectively antithermic and antibacterial role to infections caused by various virus and bacteria. 13,18 It is likely that this mechanism is responsible for the clinical improvement that is observed in our study. More rigorous studies are needed to clarify the mechanisms of TCM in treating HFMD.…”
Section: Discussionmentioning
confidence: 66%
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“…18 It has an effectively antithermic and antibacterial role to infections caused by various virus and bacteria. 13,18 It is likely that this mechanism is responsible for the clinical improvement that is observed in our study. More rigorous studies are needed to clarify the mechanisms of TCM in treating HFMD.…”
Section: Discussionmentioning
confidence: 66%
“…13 Andrographolide sulfonate is known to have many types of bioactivity, such as declining body temperature and relieving inflammation. 18 It has an effectively antithermic and antibacterial role to infections caused by various virus and bacteria.…”
Section: Discussionmentioning
confidence: 99%
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