Improving the Efficiency of Drug Administration With Jet Nebulisers

Thomas, Simon; Langford, J; George, Roger K.; Geddes, D. M.

doi:10.1016/s0140-6736(88)90331-5

Cited by 21 publications

(7 citation statements)

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“…The results of this study indicate that both storage chambers, such as the Mizer®, and Venturi nebulizers, such as the Ventstream® and Pari®, can increase the dose of drug inhaled by children as young as 3 yrs of age, and that the Venturi nebulizers appear to be the most efficient of the devices assessed. Previous studies in adults have produced similar results showing improved deposition from holding chambers [3,12] and Venturi-type nebulizers [15] as compared with standard jet nebulizers. A study in children (aged 10-16 yrs) also demonstrated enhanced drug delivery when using holding chambers [13].…”

Section: Discussionsupporting

confidence: 52%

“…These have included incorporating a manual interrupter which permits the patient to divert the driving gas flow away from the nebulizer during exhalation so that aerosol is only generated while the patient is inhaling [9][10][11]. An alternative strategy has been to store the aerosol, generated while the patient is exhaling, either in wide bore tubing connected to the exhalation port of the nebulizer or in storage chambers such as the Mizer® (MedicAid, Pagham, UK) [3,12,13]. Neither of these approaches have found widespread acceptance.…”

mentioning

confidence: 99%

“…The former significantly increases nebulization times and hence is more inconvenient for patients. Storage chambers have not been widely used, except for the administration of expensive drugs such as antibiotics, despite evidence that they do enhance drug delivery [3,12,13].…”

mentioning

confidence: 99%

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Comparison of drug delivery from conventional versus "Venturi" nebulizers

Devadason¹,

Everard²,

Linto³

et al. 1997

Eur Respir J

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Attempts to improve drug delivery from conventional jet nebulizers have included the use of storage systems to reduce drug wastage during exhalation. Venturi nebulizers enhance drug delivery during inhalation, reducing treatment times and drug wastage. This study investigated the effect of age on inhaled dose from a conventional jet nebulizer (Acorn®) used both with and without a storage chamber (Mizer®), compared to two Venturi nebulizers (Ventstream® and Pari LC®).Filters were attached to the four nebulizer systems, containing salbutamol, and 18 children with cystic fibrosis (3-16 yrs) inhaled through these devices. The quantity of drug collected on the filter was assessed using ultraviolet spectrophotometry. The particle size distribution of the aerosol from each nebulizer system was measured using laser diffraction.Inspiratory filter deposition using the Acorn® was lower than the Acorn® with Mizer®, and both Venturi nebulizers. Filter deposition using the Acorn® with Mizer® was lower than the Pari LC®. No trend with age, height or weight was noted using any nebulizer. Aerosol particle size using the Ventstream® was lower than the other nebulizer systems.Drug output from both Venturi nebulizers was more efficient than from the jet nebulizer, used with and without the storage chamber, during inhalation by children with cystic fibrosis. The inhaled dose did not change with the patient's age or size using both types of nebulizer.

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Section: Discussionsupporting

confidence: 52%

mentioning

confidence: 99%

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Comparison of drug delivery from conventional versus "Venturi" nebulizers

Devadason¹,

Everard²,

Linto³

et al. 1997

Eur Respir J

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“…The inclusion of an aerosol trapping device has also been shown to reduce antibiotic wastage during exhalation. 45 Evaporative losses of diluent lead to an increasing concentration of drug in the solution remaining in the nebuliser.3637 Also the nebuliser output is initially continuous but will eventually become intermittent and drug output will then decrease significantly.' 47 It is important to maximise nebuliser output (by tilting or gentle shaking) during the later stages of nebulisation as drug output is maximum during this phase.37 (iii) BREATHING TECHNIQUES Nasal inhalation of an aerosol results in insignificant pulmonary deposition of the aerosol.43 Inhalation must occur using the mouth only and an ideal combination is to use a mouthpiece with nose clip, while facemasks must be used as an aid to oral inhalation only.…”

Section: Methods Of Administrationmentioning

confidence: 99%

Aerosol antibiotic treatment in cystic fibrosis.

Littlewood¹,

Smye²,

Cunliffe³

1993

Archives of Disease in Childhood

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“…Ultrasonic nebulizers incorporate a piezoelectric crystal vibrating at high frequencies (1-3 MHz) in order to produce aerosol. The volume output of the ultrasonic nebulizer is about 1-6 mL/min [13,14]. Ultrasonic nebulization system is advantageous over MDIs (Metered dose inhalers) and DPIs (Dry powder inhalers) that the drug can be inhaled through a mouth-piece or facemask.…”

Section: Introductionmentioning

confidence: 99%

Development of pH-Dependent Nanospheres for Nebulisation- In vitro Diffusion, Aerodynamic and Cytotoxicity Studies

2018

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The aim of this work was to evaluate the in vitro performance of nebulized nanosuspension formulation when nebulized using ultrasonic nebulizer. The present investigation deals with successful formulation of Beclomethasone dipropionate loaded HPMCP nanospheres prepared by solvent evaporation technique using PEG 400 as a stabilizer. Beclomethasone dipropionate is a water insoluble drug molecule was encapsulated in HPMCP nanospheres to have pH dependent solubility at basic pH for targeted drug delivery in lung and studied for in vitro cytotoxicity and immediate release capability. The synthesized nanospheres were characterized through drug excipient compatibility, surface topography; mean particle size , zeta potential, PDI, entrapment efficiency and drug loading, in vitro diffusion, aerodynamic, in vitro cytotoxicity and stability studies. The mean particle size and PDI of the optimized batch (F1) had 197.6±0.40 nm and 0.324 ±0.35, respectively. The % entrapment efficiency and % drug loading was found to be 86.56±1.32 and 8.30±0.27, respectively. The optimized batch F1 showed % cumulative drug release 94.77±0.24 at 1 h. The formulation showed cell viability up to 91.28%. It can be concluded that, Beclomethasone dipropionate loaded HPMCP nanospheres was found to be safe, stable with significant increase in solubility and bypass the liver.

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Improving the Efficiency of Drug Administration With Jet Nebulisers

Cited by 21 publications

References 0 publications

Comparison of drug delivery from conventional versus "Venturi" nebulizers

Comparison of drug delivery from conventional versus "Venturi" nebulizers

Aerosol antibiotic treatment in cystic fibrosis.

Development of pH-Dependent Nanospheres for Nebulisation- In vitro Diffusion, Aerodynamic and Cytotoxicity Studies

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