Improving the evaluation of therapeutic interventions in multiple sclerosis: development of a patient-based measure of outcome

Abstract

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Cross-cultural adaptation and validation of the 12-item Multiple Sclerosis Walking Scale (MSWS-12) for the Brazilian population

“…Higher scores indicate greater impact of walking gait disability on the quality of life of patients with MS [11][12][13] . The Expanded Disability Status Scale (EDSS) is an observer-rated (the neurologist) scale which grades disability due to MS in 20 steps on a continuum from 0 (normal neurological examination) to 10 (death due to MS) [14][15][16] . The MSIS-29/BR is a MS patient-rated measurement of quality of life.…”

“…It consists of 29 questions, among which 20 address the physical impact component, and nine assess the psychological impact. A score is thus generated and reported on a scale from 0 to 100, on which lower scores indicate better quality of life [16][17][18] . The Timed 25-foot Walk (T25FW) was carried out on an area painted with a white strip, measuring 7.62 meters (25 feet), in a corridor at CATEM with an anti-slip floor surface.…”

Independent validation of Parkinson’s disease Sleep Scale 2nd version (PDSS-2)

“…The criterion for acceptable amount of missing data is <10% 22 . For acceptability the floor and ceiling effect should be kept <15% 23 and the skewness should range between -1 and +1 24 .…”

Development and psychometric testing of an instrument designed to measure chronic pain in dogs with osteoarthritis

“…Methods for the stepwise development of tools to assess subjective states that have been used extensively by researchers in the health sciences 11,12,[14][15][16][17][18][19][22][23][24][25][27][28][29][30][31][32]34,36,37 were used in the development of the CBPI. Items were generated through information gathered from focus groups and an expert panel; these items were tested for readability and ambiguity.…”

“…Standard methods for the development and psychometric testing of instruments designed to assess subjective states [10][11][12][13]15,[18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] were used for development of the CBPI. Factor format, item structure, and response scaling of the CBPI were based on the rigorously tested BPI, which is an instrument routinely used to provide a broad picture of the effect of chronic pain on human patients.…”