Ahead of the Curve T he doubling of the National Institutes of Health (NIH) budget in the new millennium, combined with the rapid acceleration in biomedical research discoveries, increased the urgency of translating laboratory results and proven medical advances into tangible, health-related outcomes. In 2006, after extensive consultation with stakeholders, the NIH, with Elias Zerhouni, MD, as the director, opened the Clinical and Translational Science Awards (CTSAs) program, a multiyear cooperative initiative designed to increase the effi ciency of translation of research from the laboratory through the developmental pipeline into research in the clinic and then into the community in an iterative fashion. Currently, 60 funded academic health centers (AHCs) are actively engaged in the transformation of health-care research by improving the translation of research and discovery from laboratory to clinic and community and back again. Relevant information about the CTSAs can be found at the CTSA Consortium Web site, www.ctsaweb.org. The transformation includes the development of publicprivate partnerships, the educational preparation of the next generation of translational investigators, the improvement of clinical research management, the engagement of communities in a bidirectional dialog, and the establishment of informatics and communication tools that support a broad range of research activities. The CTSA institutions, with the leadership of the principal investigators and their teams, are developing regional and national consortia; participating