Improving the knowledge on <i>Piper betle</i>: Targeted metabolite analysis and effect on acetylcholinesterase

Valentão, Patrı́cia; Gonçalves, Rui F.; Belo, Cristóvão; Pinho, Paula Guedes de; Andrade, Paula B.; Ferreres, Federico

doi:10.1002/jssc.201000429

Cited by 21 publications

(13 citation statements)

References 35 publications

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“…Essential oils (Bajpai, Sharma, Kumar, & Madhusudanan, ; Jirovetz, Puschmann, Buchbauer, & Muhammad, ; Karak et al, ; Kumar et al, ; Saxena, Khare, Saxena, Syamsundar, & Srivastava, ; Suryasnata, Sandeep, Parida, Nayak, & Mohanty, ) and some important phenols, for example, hydroxychavicol and its acetate form (Ali et al, ; Amonkar, Nagabhusan, D’Souza, & Bhide, ; Pin et al, ) were reported from the leaves of P. betle . Some other non‐volatile components, for example, amino acids, sugars, organic acids, polyols, fatty acids, terpenes, and phenolic compounds have also been reported previously (Karak, Bhattacharya, Nandy, Saha, & De, ; Valentão et al, ) from P . betle leaves.…”

Section: Introductionsupporting

confidence: 69%

Phytochemical composition, β‐glucuronidase inhibition, and antioxidant properties of two fractions of Piper betle leaf aqueous extract

et al. 2019

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Rationale: Piper betle leaf, used as masticatory in South Asia, is also medicinally important. Objective: This work was done to analyze phytochemical composition of two solvent fractions (chloroform and ethyl acetate) of the aqueous extracts obtained from eight varieties of P. betle leaves and to identify the active components against β-glucuronidase by chemometric analysis. Results: Twenty-four phenolic compounds, in addition to different organic acids, fatty acids, amino acids, sugars, and polyols, were identified from the solvent fractions. The extracts inhibited the enzyme β-glucuronidase. Piceatannol was the most active constituent against the enzyme (activity 12 times higher than that of silymarin), Chlorogenic acid also inhibited β-glucuronidase (activity 4.4 times higher when compared to silymarin). 2,2′-Diphenyl-1picrylhydrazyl and superoxide free radical scavenging activities of both the fractions of eight varieties of P. betle leaf extracts showed very strong antioxidant potentiality. Conclusion: The findings validated some medicinal properties of the said leaves. Practical applications Edible leaves of Piper betle are medicinally and economically important. Leaves of different local varieties are reported to be used for the treatment of different diseases. The leaves have many biological properties, hepatoprotection being one of them. A large number of rural population is economically dependent on the cultivation of betel vine. But with a rapid change in lifestyle, the chewing habit of P. betle is decreasing ultimately affecting the livelihood of farmers dependent on betel cultivation. Knowledge on β-glucuronidase inhibitory activity and the mechanism for hepatoprotection of different P. betle varieties may validate the medicinal properties of betel, which would increase consumption of these leaves. K E Y W O R D S antioxidant, chemometrics, hepatoprotection, Piper betle leaves, β-glucuronidase inhibitors 1 | INTRODUC TI ON Edible leaves of Piper betle L., largely used for chewing in the South Asian countries, are also known for their immense medicinalproperties. In India, the leaves are traditionally used to treat various diseases (Guha, 2006). There are reports regarding the antioxidant

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Section: Introductionsupporting

confidence: 69%

Phytochemical composition, β‐glucuronidase inhibition, and antioxidant properties of two fractions of Piper betle leaf aqueous extract

et al. 2019

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“…The Piper betel leaf is used in folk medicine for treatment of several situations [72], and the leaf extracts are experimentally shown to be useful as antimicrobial [73], anti-leishmanial [74], antimalarial [75], anti-filarial [76], anti-fungal [77], anti-allergic [78], immunomodulator [79], gastroprotective [80], antioxidant [81], and anti-inflammatory [82] agents. We performed literature mining and collected 128 active phytochemicals from betel leaf and used them to screen against these two targets.…”

Section: Resultsmentioning

confidence: 99%

Exoproteome and Secretome Derived Broad Spectrum Novel Drug and Vaccine Candidates in Vibrio cholerae Targeted by Piper betel Derived Compounds

et al. 2013

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Vibrio cholerae is the causal organism of the cholera epidemic, which is mostly prevalent in developing and underdeveloped countries. However, incidences of cholera in developed countries are also alarming. Because of the emergence of new drug-resistant strains, even though several generic drugs and vaccines have been developed over time, Vibrio infections remain a global health problem that appeals for the development of novel drugs and vaccines against the pathogen. Here, applying comparative proteomic and reverse vaccinology approaches to the exoproteome and secretome of the pathogen, we have identified three candidate targets (ompU, uppP and yajC) for most of the pathogenic Vibrio strains. Two targets (uppP and yajC) are novel to Vibrio, and two targets (uppP and ompU) can be used to develop both drugs and vaccines (dual targets) against broad spectrum Vibrio serotypes. Using our novel computational approach, we have identified three peptide vaccine candidates that have high potential to induce both B- and T-cell-mediated immune responses from our identified two dual targets. These two targets were modeled and subjected to virtual screening against natural compounds derived from Piper betel. Seven compounds were identified first time from Piper betel to be highly effective to render the function of these targets to identify them as emerging potential drugs against Vibrio. Our preliminary validation suggests that these identified peptide vaccines and betel compounds are highly effective against Vibrio cholerae. Currently we are exhaustively validating these targets, candidate peptide vaccines, and betel derived lead compounds against a number of Vibrio species.

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“…Given that it is a cheap and readily accessible natural product, various parts of the Piper betel plant especially betel leaves, are used in traditional medicine for treatment of several conditions such as abscesses, constipation, conjunctivitis, itches, rheumatism, abrasions, and many more (14,15). Although the roots of Piper betel have served as alternative oral contraceptives, the oil obtained from betel leaves has bactericidal action (13).…”

Section: Some Plants Have It All: the Versatile Pharmacopoeia Of Pipementioning

confidence: 99%

Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties

Gundala

Aneja

2014

Cancer Prevention Research

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Plants contain a much greater diversity of bioactive compounds than any man-made chemical library. Heart-shaped Piper betel leaves are magnificent reservoirs of phenolic compounds with antiproliferative, antimutagenic, antibacterial, and antioxidant properties. Widely consumed in South Asian countries, the glossy leaf contains a multitude of biophenolics such as hydroxychavicol, eugenol, chavibetol, and piperols. Convincing data underscore the remarkable chemotherapeutic and chemopreventive potential of betel leaves against a variety of cancer types. The leaf constituents modulate an extensive array of signaling molecules such as transcription factors as well as reactive oxygen species (ROS) to control multiple nodes of various cellular proliferation and death pathways. Herein, we provide an overall perspective on the cancerfighting benefits of the phenolic phytochemicals in betel leaves and a comprehensive overview of the mechanisms responsive to dose-driven ROS-mediated signaling cascades conscripted by bioactive phenolics to confer chemotherapeutic and chemopreventive advantages. Intriguingly, these ROS-triggered responses are contextual and may either elicit a protective xenohormetic antioxidant response to premalignant cells to constitute a chemopreventive effect or generate a curative chemotherapeutic response by pro-oxidatively augmenting the constitutively elevated ROS levels in cancer cells to tip the balance in favor of selective apoptosis induction in cancer cells while sparing normal ones. In conclusion, this review provides an update on how distinct ROS levels exist in normal versus cancer cells and how these levels can be strategically modulated and exploited for therapeutic gains. We emphasize the yet untapped potential of the evergreen vine, betel leaf, for chemopreventive and chemotherapeutic management of cancer. Cancer Prev Res; 7(5);

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Improving the knowledge on Piper betle: Targeted metabolite analysis and effect on acetylcholinesterase

Cited by 21 publications

References 35 publications

Phytochemical composition, β‐glucuronidase inhibition, and antioxidant properties of two fractions of Piper betle leaf aqueous extract

Phytochemical composition, β‐glucuronidase inhibition, and antioxidant properties of two fractions of Piper betle leaf aqueous extract

Exoproteome and Secretome Derived Broad Spectrum Novel Drug and Vaccine Candidates in Vibrio cholerae Targeted by Piper betel Derived Compounds

Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties

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