“…11 A vast of surfaces with various gradients of wettability, 12 stiffness, 13 biological signals, 14 and organic-inorganic transition. 15 have been fabricated via the methods of controlled diffusion of reaction medium (liquid phase 16 and vapor 17 ), electrochemically promoted reaction by controlling the angle of inclination between electrode and target substrate, 18,19 microfluidic control, 20 microstructure patterns, 21 gradient temperature, 22 gradient exposure to UV, 23 and processive immersion. 24 Poly(ethylene glycol) (PEG) is well acknowledged as a safe macromolecule that has been frequently used as an ingredient of functional biomaterials, such as, antifouling, 25 drug-loading, 26,27 hydrogel, 28 medical adhesive 29 and biological scaffold.…”