Standard cognitive assessment tools often involve motor or verbal responses, making them impossible for severely motor-disabled individuals. Brain-computer interfaces (BCIs) are expected to help severely motor-impaired individuals to perform cognitive assessment because BCIs can circumvent motor and verbal requirements. Currently, the field of research to develop cognitive tasks based on BCI is still in its nascent stage and needs further development. This study explored the possibility of developing a BCI version of symbol digit modalities test (BCI-SDMT). Steady-state visual evoked potential (SSVEP) was adopted to build the BCI and a 9-target SSVEP-BCI was realized to send examinees' responses.A training-free algorithm (i.e., filter bank canonical correlation analysis) was used for SSVEP identification. Thus, examinees are able to start the proposed BCI-SDMT immediately. Eighty-nine healthy elderly volunteers and 9 stroke patients were enrolled to validate the technical feasibility of the developed BCI-SDMT. For all participants, the average recognition accuracies of the developed BCI and BCI-SDMT were 93.89 ± 8.48% and 92.58 ± 10.52%, respectively, were considerably above the chance level (i.e., 11.11%). These results indicated that both healthy elderly volunteers and stroke patients could elicit sufficient SSVEPs to control the BCI. Furthermore, patient use of the developed BCI-SDMT was unaffected by the presence of motor impairment. They could understand instructions, pair numbers with specific symbols, and send commands using the BCI. The proposed BCI-SDMT can be used as a