Improving the photostability of curcumin using functional star-shaped polyamidoamine dendrimer: Application on PET

Dodangeh, Mohammad; Gharanjig, Kamaladin

doi:10.1016/j.mtcomm.2019.100620

Cited by 14 publications

(11 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The order of photostability was F8 > F7 > F6 > F5 > F4 > F3 > F2 > F1 > pure P18. This suggests that the SLN structurally protects the entrapped drug from the external environment [ 41 , 42 , 43 ]. In addition, the photostability results were proportional to the LE results of the loading capacity experiment.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Design of Purpurin-18-Loaded Solid Lipid Nanoparticles for Improved Anticancer Efficiency of Photodynamic Therapy

et al. 2022

View full text Add to dashboard Cite

Purpurin-18 (P18) is one of the essential photosensitizers used in photodynamic therapy (PDT), but its hydrophobicity causes easy coalescence and poor bioavailability. This study aimed to synthesize P18 and design P18-loaded solid lipid nanoparticles (SLNs) to improve its bioavailability. The characteristics of the synthesized P18 and SLNs were evaluated by particle characteristics and release studies. The effects of P18 were evaluated using the 1,3-diphenylisobenzofuran (DPBF) assay as a nonbiological assay and a phototoxicity assay against HeLa and A549 cell lines as a biological assay. The mean particle size and zeta potential of the SLNs were 164.70–762.53 nm and −16.77–25.54 mV, respectively. These results indicate that P18-loaded SLNs are suitable for an enhanced permeability and retention effect as a passive targeting anti-cancer strategy. The formulations exhibited a burst and sustained release based on their stability. The DPBF assay indicated that the PDT effect of P18 improved when it was entrapped in the SLNs. The photocytotoxicity assay indicated that P18-loaded SLNs possessed light cytotoxicity but no dark cytotoxicity. In addition, the PDT activity of the formulations was cell type- and size-dependent. These results suggest that the designed P18-loaded SLNs are a promising tool for anticancer treatment using PDT.

show abstract

Section: Resultsmentioning

confidence: 99%

Synthesis and Design of Purpurin-18-Loaded Solid Lipid Nanoparticles for Improved Anticancer Efficiency of Photodynamic Therapy

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The Cur photostability of the formulations decreased in the following order after 40 min: F11 > F10 > F9 > F8 > F7 > F4 > F5 > F6 > F3 > F2 > F1 > Cur. This is because SLN can structurally protect encapsulated drugs from the external environment. − Thus, the photodegradation of Cur was inhibited. Concerning the effects of lipids and surfactants, formulations using lipids with long carbon chains and surfactants with high hydrophilicity tended to have high photostability.…”

Section: Resultsmentioning

confidence: 99%

“…Solid lipid nanoparticle (SLN) systems appear to be an efficient approach for increasing the aqueous solubility and stability of drugs and decreasing the particle size to the nanoscale level. ,− In SLN systems, a lipophilic drug is stably dispersed in the water solvent by loading a lipid matrix of SLN via preparing an oil-in-water (O/W) phase. ,, The solid structure of the SLN system protects an unstable drug from environmental factors such as light, pH, and atmospheric moisture. − In particular, SLN can be delivered into the lymphatic system upon oral administration by bypassing the liver via forming chylomicrons in enterocytes. , Thus, drugs embedded in SLNs effectively avoid hepatic first-pass metabolism, enhancing the pharmacological effects of the drug. ,,, Moreover, this formulation can be used as a brain-targeted drug delivery system when absorbed into the systemic circulation, overcoming one of the most important challenges in pharmaceutical sciences. , Although the blood–brain barrier, a highly selective semipermeable border, protects the brain parenchyma against circulating toxins or pathogens, it allows the diffusion of hydrophobic molecules …”

Section: Introductionmentioning

confidence: 99%

“… 10 , 29 , 30 The solid structure of the SLN system protects an unstable drug from environmental factors such as light, pH, and atmospheric moisture. 31 − 34 In particular, SLN can be delivered into the lymphatic system upon oral administration by bypassing the liver via forming chylomicrons in enterocytes. 35 , 36 Thus, drugs embedded in SLNs effectively avoid hepatic first-pass metabolism, enhancing the pharmacological effects of the drug.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Solid Lipid Nanoparticles of Curcumin Designed for Enhanced Bioavailability and Anticancer Efficiency

et al. 2022

View full text Add to dashboard Cite

Curcumin (Cur) has anticancer properties but exhibits poor aqueous solubility, permeability, and photostability. In this study, we aimed to develop a solid lipid nanoparticle (SLN) system to enhance Cur bioavailability. The characteristics of Cur-loaded SLNs prepared by sonication were evaluated using UV−vis and Fourier transform infrared spectroscopy. The mean particle size of the stearic acid-based, lauric acid-based, and palmitic acid-based SLNs was 14.70−149.30, 502.83, and 469.53 nm, respectively. The chemical interactions between Cur and lipids involved hydrogen bonding and van der Waals forces. The formulations with high van der Waals forces might produce a neat arrangement between Cur and lipids, leading to a decrease in particle size. The Cur formulations showed enhanced cytotoxicity in HeLa, A549, and CT-26 cells compared with pure Cur. Additionally, the anticancer effect is dependent on particle size and the type of cell line. Therefore, Cur-loaded SLNs have the potential for use in anticancer therapy.

show abstract

“…Furthermore, for the majority of chemically sensitive phenolics, light irradiation has been identified as a determining factor for decomposition process mechanisms and rates [259,262]. Therefore, many phenolic compounds are known to be susceptible to photodegradation (resveratrol [263], curcumin [264], hypericin [255], hyperforin [31], eugenol [265], quercetin [266], and many others) [267]. Furthermore, polymerization is another undesirable event for some simple phenols and polyphenols (catalyzed or not by oxidation processes) [259,268], which leads to substantial changes in their pharmacological activity, molecular mass, and skin permeation potential.…”

Section: Stability Of Phenolicsmentioning

confidence: 99%

Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

et al. 2021

View full text Add to dashboard Cite

Phenolic compounds are a large, heterogeneous group of secondary metabolites found in various plants and herbal substances. From the perspective of dermatology, the most important benefits for human health are their pharmacological effects on oxidation processes, inflammation, vascular pathology, immune response, precancerous and oncological lesions or formations, and microbial growth. Because the nature of phenolic compounds is designed to fit the phytochemical needs of plants and not the biopharmaceutical requirements for a specific route of delivery (dermal or other), their utilization in cutaneous formulations sets challenges to drug development. These are encountered often due to insufficient water solubility, high molecular weight and low permeation and/or high reactivity (inherent for the set of representatives) and subsequent chemical/photochemical instability and ionizability. The inclusion of phenolic phytochemicals in lipid-based nanocarriers (such as nanoemulsions, liposomes and solid lipid nanoparticles) is so far recognized as a strategic physico-chemical approach to improve their in situ stability and introduction to the skin barriers, with a view to enhance bioavailability and therapeutic potency. This current review is focused on recent advances and achievements in this area.

show abstract

Improving the photostability of curcumin using functional star-shaped polyamidoamine dendrimer: Application on PET

Cited by 14 publications

References 35 publications

Synthesis and Design of Purpurin-18-Loaded Solid Lipid Nanoparticles for Improved Anticancer Efficiency of Photodynamic Therapy

Synthesis and Design of Purpurin-18-Loaded Solid Lipid Nanoparticles for Improved Anticancer Efficiency of Photodynamic Therapy

Solid Lipid Nanoparticles of Curcumin Designed for Enhanced Bioavailability and Anticancer Efficiency

Dermal Drug Delivery of Phytochemicals with Phenolic Structure via Lipid-Based Nanotechnologies

Contact Info

Product

Resources

About