Improving the photothermal therapy efficacy and preventing the surface oxidation of bismuth nanoparticles through the formation of a bismuth@bismuth selenide heterostructure

Li, Bing; Cheng, Yan; Zheng, Rong; Wu, Xiaqing; Fan, Qi; Wu, Yunyun; Hu, Yaqing; Li, Xi

doi:10.1039/d0tb00825g

Cited by 21 publications

(8 citation statements)

References 33 publications

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“…In order to improve the photothermal conversion efficacy, Bi@Bi 2 Se 3 heterostructure NPs were designed to present their staggered energy levels. 50 With NIR laser irradiation, the excited electrons on CB of Bi could transfer to CB of Bi 2 Se 3 , and the excited holes on the VB of Bi 2 Se 3 could transfer to the VB of Bi, both of which finally recombine nonradiatively at the interface to produce more phonons for improving photothermal performance (Figure 6K). In fact, Bi@Bi 2 Se 3 NPs showed excellent PTT efficacy against cancer cells.…”

Section: Extremely Narrow Band Gap-induced Photothermal Therapymentioning

confidence: 99%

“…Copyright 2018 American Chemical Society). (K) Potential mechanism for improved photothermal performance of Bi@Bi 2 Se 3 NPs (Reprinted with permission from ref . Copyright 2020 The Royal Society of Chemistry).…”

Section: Electronic Property-modulated Photothermal Therapy (Ptt) Wit...mentioning

confidence: 99%

“…When these hot carriers return to CB and VB, respectively, excess kinetic energy could be released, thus emitting phonons and inducing photothermal performance. In order to improve the photothermal conversion efficacy, Bi@Bi 2 Se 3 heterostructure NPs were designed to present their staggered energy levels . With NIR laser irradiation, the excited electrons on CB of Bi could transfer to CB of Bi 2 Se 3 , and the excited holes on the VB of Bi 2 Se 3 could transfer to the VB of Bi, both of which finally recombine nonradiatively at the interface to produce more phonons for improving photothermal performance (Figure K).…”

Section: Electronic Property-modulated Photothermal Therapy (Ptt) Wit...mentioning

confidence: 99%

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Electronic Band-Engineered Nanomaterials for Biosafety and Biomedical Application

Cheng

Zhang

2021

Acc. Mater. Res.

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Conspectus Interaction between nanomaterials (NMs) and biological systems can be beneficial for biological functions but also can present hazards to humans. Nanotoxicology and nanomedicine, as two subdisciplines of nanotechnology, share the same goal of making safer NMs for biomedical application. NMs with unique electronic properties have been widely used for biomedical applications, such as bacterial inactivation, wound healing, tumor therapy, and Alzheimer’s disease therapy. Meanwhile, the biosafety of NMs has become a hot topic, and development of effective “safe-by-design” strategies will be beneficial for the wide applications of NMs in the biomedical field. However, it is currently hard to establish a property–activity relationship between NMs and their biosafety and biomedical applications, especially for electronic band structure including conduction band energy (E c), valence band energy (E v), Fermi energy (E f), and bandgap energy (E g). E g determines the suitable lights used to excite NMs, and E c and E v determine the redox abilities of photoinduced electrons and holes, while E f dominates the charge transfer process within NMs. Therefore, through modulating the electronic band structure of NMs, not only can the biosafety of NMs be elevated, but also the photoelectronic performance can be improved, providing a profound understanding to the design of functional NMs for the biomedical application with excellent biocompatibility. In this account, we focus on our recent progress in electronic band structure-modulated NMs for biosafety and biomedical application. First, we investigate the toxicities of NMs with different E c levels and establish safe-by-design strategies to make safer NMs through modulating their electronic properties, such as tuning E c values of NMs out of the biological redox potential range and tuning the E f edge far away from the E v edge. Second, we propose that deep level defect, resonance energy transfer, and narrow band gap intensely correlate with the photothermal performance of NMs and rationally designed heterostructures can significantly improve the photothermal conversion efficacies of these NMs. Third, we introduce a series of NMs with unique heterostructure to promote photoinduced electron–hole spatial separation and improve photodynamic performance for antibacterial and anticancer applications. Among these heterostructures, the thermally retractable heterostructure can create a favorable microenvironment for photodynamic therapy; Z-scheme heterostructure can simultaneously produce oxygen and reactive oxygen species for photodynamic therapy against hypoxic tumor; plasmon–pyroelectric heterostructure can thermally generate reactive oxygen species in an oxygen-independent manner for hypoxic tumor therapy. Furthermore, we describe the photooxidation and antioxidant abilities of NMs for treating Alzheimer’s disease through inhibiting amyloid-β self-assembly and scarifying reactive oxygen species. Finally, we propose the challenges and perspectives of electronic band structu...

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Section: Extremely Narrow Band Gap-induced Photothermal Therapymentioning

confidence: 99%

Section: Electronic Property-modulated Photothermal Therapy (Ptt) Wit...mentioning

confidence: 99%

Section: Electronic Property-modulated Photothermal Therapy (Ptt) Wit...mentioning

confidence: 99%

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Electronic Band-Engineered Nanomaterials for Biosafety and Biomedical Application

Cheng

Zhang

2021

Acc. Mater. Res.

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“…However, Bi nanoparticles are unstable and easily oxidized by oxygen in air or medium, leading to the loss of light absorption ability and photothermal effect . Although surface coatings and heterostructures have been designed to protect them from oxidation, ,, further exploration and successful utilization of the oxidization process have never been carried out. We studied the oxidization process of Bi and attempted to change it from a detrimental to a beneficial influence, specifically to offer another simple therapeutic mode.…”

Section: Introductionmentioning

confidence: 99%

On-Demand Triggered Chemodynamic Therapy by NIR-II Light on Oxidation-Prevented Bismuth Nanodots

Yang

Jia

Song

et al. 2022

ACS Appl. Mater. Interfaces

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As the least toxic heavy metal, monoelemental bismuth nanomaterials with several superiorities are the ideal theranostic agents. However, bismuth nanoparticles are easily oxidized by oxygen in air or media, limiting their clinical application. In contrast, the oxidization of Bi0 to Bi3+ can activate the chemodynamic therapy (CDT) by transferring endogenous H2O2 into •OH. Herein, a well-designed Bi-DMSNs@PCM nanosystem was prepared via in situ growth of Bi nanodots and a coating of phase-change material (PCM) on the surface of dendritic mesoporous silica nanoparticles (DMSNs). The coated PCM protects the Bi nanodots from oxidation by keeping them in the Bi0 state for more than 15 d. When irradiated using the near infrared-II (NIR-II) laser with a low power density (0.5 W/cm2), the heat generated from the Bi nanodots melts the PCM shell to trigger CDT through a Fenton-like reaction, accompanied by heat-induced photothermal therapy (PTT). Notably, the CDT can also compensate for the reduced PTT effect caused by the oxidation of Bi nanodots, and a satisfactory treatment effect is realized. Additionally, photoacoustic and computed tomography imaging properties were obtained. Our strategy transfers the detrimental self-oxidation of bismuth to a beneficial therapeutic mode, enhancing the potential of Bi for clinical use.

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“…However, the high price of precious metal materials could further inhibit their application in PTT for tumors. As a nontoxic and cheap nanomaterial, bismuth (Bi) has gradually become an important PTT agent. − Although a series of Bi-based materials (such as Bi 2 S 3 , − Bi 2 Te 3 , and Bi 2 Se 3 − ) for PTT have been studied, a certain amount of sulfide or selenide is often added in the synthesis process, which may cause metabolic difficulties and toxicity. Accordingly, single Bi nanoparticles have great potential in PTT.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Bi NSs@BSA Nanoplatform Guided by CT Imaging for Effective Photothermal Therapy

Zhang

Liu

Shu³

et al. 2022

Langmuir

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Photothermal therapy (PTT) has attracted great attention as an anticancer treatment strategy. With the rapid development of nanomedicine, multifunctional inorganic nanophotothermal agents provide a new way to improve the effect of PTT. Herein, bovine serum albumin (BSA)-modified Bi nanosheets (Bi NSs) with good biocompatibility were synthesized by a facile redox and ball milling method and applied as a photothermal agent for the enhancement of PTT. Owing to the strong near-infrared absorption, Bi NSs exhibit high photothermal conversion efficiency (η = 36.17%) under 808 nm laser irradiation and can serve as a nanotherapeutic agent for cancer therapy. In addition, in vitro cell safety analysis also suggests that the toxicity of BSA-modified Bi NSs is negligible. Upon 808 nm irradiation, the uptake ability of tumor cells to Bi NSs@BSA has been improved. Moreover, Bi NSs@BSA also can be used as a good contrast agent for CT imaging and then to observe the distribution of materials in the tumor site. Finally, Bi NSs@BSA-mediated PTT results show a high ablation rate of A549 tumor cells both in vitro and in vivo. All results reveal that Bi NSs@BSA is a promising nanotherapeutic platform for PTT.

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Improving the photothermal therapy efficacy and preventing the surface oxidation of bismuth nanoparticles through the formation of a bismuth@bismuth selenide heterostructure

Abstract: Bismuth (Bi) nanoparticles (NPs) are emerging as promising a photothermal agent for computed tomography imaging guided photothermal therapy. However, it would be a challenge to improve its photothermal conversion efficacy...

Cited by 21 publications

References 33 publications

Electronic Band-Engineered Nanomaterials for Biosafety and Biomedical Application

Electronic Band-Engineered Nanomaterials for Biosafety and Biomedical Application

On-Demand Triggered Chemodynamic Therapy by NIR-II Light on Oxidation-Prevented Bismuth Nanodots

Multifunctional Bi NSs@BSA Nanoplatform Guided by CT Imaging for Effective Photothermal Therapy

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