Improving the processability of pharmaceutical powders using atomic layer coating

Swaminathan, Shrikant; Ganapathy, Balaji; Wang, Miaojun; Wang, Fei; Wooding, Jamie P.; Frankel, Jonathan; Chiruvolu, S.; Rengarajan, S.; Narwankar, P. K.

doi:10.1016/j.powtec.2023.118525

Cited by 6 publications

(2 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, the coating provided prolonged release of the antigen and a boost response, while the aluminum released from the coating added an adjuvant effect . ALC coating can also effectively improve powder processability by enhancing flowability, compressibility, and density, which enables smooth continuous manufacturing processes, direct compression, and uniform vial filling processes …”

Section: Introductionmentioning

confidence: 99%

“…24 ALC coating can also effectively improve powder processability by enhancing flowability, compressibility, and density, which enables smooth continuous manufacturing processes, direct compression, and uniform vial filling processes. 25 Other than the examples above, there have been very few reports of biomolecule formulations subjected to ALC coating: tobacco mosaic virus and ferritin are two early examples of biomacromolecules that were used as biotemplates for nanofabrication using ALC. 26 Despite the potential of ALC for improving the stability of proteins in the solid state, the recent study by Garcea et al is the only one to have indirectly investigated the effect of aluminum oxide coating on protein stability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Atomic Layer Coating on the Stability of Solid Myoglobin Formulations

et al. 2023

Self Cite

View full text Add to dashboard Cite

The effects of atomic layer (ALC) coating on physical properties and storage stability were examined in solid powders containing myoglobin, a model protein. Powders containing myoglobin and mannitol (1:1 w/w) were prepared by lyophilization or spray drying and subjected to aluminum oxide or silicon oxide ALC coating. Uncoated samples of these powders as well as coated and uncoated samples of myoglobin as received served as controls. After preparation (t 0 ), samples were analyzed for moisture content, reconstitution time, myoglobin secondary structure, crystallinity, and protein aggregate content. Samples were stored for 3 months (t 3 ) under controlled conditions (53% RH, 40 °C) in both open and closed vials and then analyzed as above. At t 3 , the recovery of soluble native (i.e., monomeric) protein depended on formulation, coating type, and drying method and was up to 2-fold greater in coated samples than in uncoated controls. Promisingly, some samples with high recovery also showed low soluble aggregate content (<10%) at t 3 and low total monomer loss; the latter was correlated to sample moisture content. Overall, the results demonstrate that ALC coatings can stabilize solid protein formulations during storage, providing benefits over uncoated controls.

show abstract

Section: Introductionmentioning

confidence: 99%