Improving the productivity of gibberellic acid by combining small-molecule compounds-based targeting technology and transcriptomics analysis in Fusarium fujikuroi

Shi, Tian-Qiong; Shen, Yi-hang; Li, Ya-Wen; Huang, Zi-Yi; Nie, Zhi-Kui; Ye, Chao; Wang, Yue-Tong; Guo, Qi

doi:10.1016/j.biortech.2024.130299

Cited by 1 publication

(1 citation statement)

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“…This available information has allowed that different works can be focused on the use of raw materials with the purpose of solving two problems, the increase of GA 3 production and the waste utilization of residues from different agro-industries. The most employed raw materials are starch [ 68 ], corn flour [ 69 ], wheat bran [ 70 ], rice bran [ 7 ], barley flour, citrus pulp [ 71 ], corn starch [ 72 ], rice flour [ 8 ], and soybean flour [ 73 ], among others.…”

Section: Ga 3 Productionmentioning

confidence: 99%

Bioprocess of Gibberellic Acid by Fusarium fujikuroi: The Challenge of Regulation, Raw Materials, and Product Yields

Hernández Rodríguez,

Díaz Pacheco,

Martínez Tolibia

et al. 2024

JoF

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Gibberellic acid (GA3) is a tetracyclic diterpenoid carboxylic acid synthesized by the secondary metabolism of Fusarium fujikuroi. This phytohormone is widely studied due to the advantages it offers as a plant growth regulator, such as growth stimulation, senescence delay, flowering induction, increased fruit size, and defense against abiotic or biotic stress, which improve the quality and yield of crops. Therefore, GA3 has been considered as an innovative strategy to improve agricultural production. However, the yields obtained at large scale are insufficient for the current market demand. This low productivity is attributed to the lack of adequate parameters to optimize the fermentation process, as well as the complexity of its regulation. Therefore, this article describes the latest advances for potentializing the GA3 production process, including an analysis of its origins from crops, the benefits of its application, the related biosynthetic metabolism, the maximum yields achieved from production processes, and their association with genetic engineering techniques for GA3 producers. This work provides a new perspective on the critical points of the production process, in order to overcome the limits surrounding this modern line of bioengineering.

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