Improving the rhinomanometry technique using benzoin tincture

Arslan, Fatih; Yildizoglu, Uzeyir; Durmaz, Abdullah; Çetinkaya, Serdar

doi:10.1017/s0022215118000531

Cited by 3 publications

(4 citation statements)

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“…There are a variety of techniques and routes of administration used to deliver this life-saving drug including IM injections by syringes or autoinjectors and IN devices. 19,20 . Parenteral injections require technique and training that most individuals do not possess and even automatic injectors can be difficult to use possessing additional burdensome considerations such as accidental misfiring and needle sticks.…”

Section: Discussionmentioning

confidence: 99%

“…[13][14][15][16][17] Botanical-sourced benzoin gum resins as tinctures are used commercially over-the-counter in the medical arts for enhancing adherence of surgical bandages as well as mucosal adhesive properties for use as oral mucosal protectant applications. 18,19 We sought to test the feasibility of tincture of Styrax benzoin (TOB) resin, exploiting its mucoadhesive properties, to deliver naloxone systemically. Here we report a PK proof-of-concept transbuccal delivery of naloxone-HCl formulated with commercially available alcoholic tincture of Styrax benzoin swabbed onto the buccal mucosal surface of dogs, a standard animal for evaluating transbuccal systemic delivery of drugs in humans.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics Of Transbuccal Swab-Administered Naloxone-HCl Using A Novel Plant-Based Resin Formulation In Dogs

Johnson¹,

Azimi²,

Schnipper³

2020

Preprint

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A proof-of-concept transbuccal swab delivery of naloxone-HCL study using a mucoadhesive, plant-based film-forming resin formulation demonstrated comparable blood levels to benchmark intramuscular (IM) injection in highly predictive dog model. Results from this study allow the potential to translate rapid onset in humans with therapeutic blood levels being reached in 2-3 minutes comparable to that observed with commercially available parenteral injections and intranasal administrations. The simplicity, ease of delivery and rapid effectiveness has the potential to meet the public health emergency needs in the rescue of opioid overdosing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics Of Transbuccal Swab-Administered Naloxone-HCl Using A Novel Plant-Based Resin Formulation In Dogs

Johnson¹,

Azimi²,

Schnipper³

2020

Preprint

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“…Rhinomanometry is a non-invasive test that has been used since 1983 to measure nasal functions, and it correlates best with physical examination findings 17 , 18 . When evaluated together with physical examination findings, rhinomanometry is now accepted as the ‘gold standard’ for the assessment of nasal obstruction 19 , 20 . We conducted an objective evaluation of the relationship between nasal functions and middle-ear pathology by measuring nasal functions with active anterior rhinomanometry, which is considered the ideal method for nasal function evaluation.…”

Section: Discussionmentioning

confidence: 99%

Assessment of nasal functions and their relationship with cholesteatoma formation in patients with unilateral chronic otitis media

2018

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ObjectivesTo evaluate the nasal functions of patients with unilateral chronic otitis media using rhinomanometry, comparing chronic otitis media sides with healthy sides, chronic otitis media patients with cholesteatoma and without cholesteatoma, and patients with healthy individuals.MethodsThis prospective study included 102 patients with unilateral chronic otitis media (48 with and 54 without cholesteatoma). The control group comprised 40 individuals without any ear or nasal pathologies. All patients underwent active anterior rhinomanometry to measure nasal airway resistance and a saccharin test to measure mucociliary transport times.ResultsThere were no significant differences in nasal airway resistance and mucociliary transport time between the chronic otitis media sides and unaffected sides in the 102 patients (p = 0.72 and p = 0.28, respectively), between the non-suppurative chronic otitis media patients (without cholesteatoma) and chronic otitis media with cholesteatoma patients (p > 0.05), or between the study and control groups (p > 0.05).ConclusionThe present study, with a larger sample size compared to previously published literature, supports the conclusion that unilateral nasal obstruction is unlikely to lead to chronic otitis media on the same side. The results also suggest that nasal functions do not contribute to the development of cholesteatoma.

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“…The study by Arslan et al 4 . describes a simple and elegant method of improving the reliability and speed of performing anterior rhinomanometry.…”

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confidence: 99%

The increased incidence of bony metastasis in p16-positive oropharyngeal carcinoma, a method to enhance reliability and speed for performing anterior rhinomanometry, and the new Soundbridge middle-ear implant and magnetic resonance imaging compatibility

Hussain¹,

Fisher²,

Fishman³

2018

J. Laryngol. Otol.

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Improving the rhinomanometry technique using benzoin tincture

Abstract: The use of benzoin tincture to clean the nasal skin before placing foam tape shortens the procedure duration and significantly increases test reliability.

Cited by 3 publications

References 10 publications

Pharmacokinetics Of Transbuccal Swab-Administered Naloxone-HCl Using A Novel Plant-Based Resin Formulation In Dogs

Pharmacokinetics Of Transbuccal Swab-Administered Naloxone-HCl Using A Novel Plant-Based Resin Formulation In Dogs

Assessment of nasal functions and their relationship with cholesteatoma formation in patients with unilateral chronic otitis media

The increased incidence of bony metastasis in p16-positive oropharyngeal carcinoma, a method to enhance reliability and speed for performing anterior rhinomanometry, and the new Soundbridge middle-ear implant and magnetic resonance imaging compatibility

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