Improving the Separation in Microchip Electrophoresis by Surface Modification

Fernández‐Abedul, M. Teresa; Álvarez‐Martos, Isabel; Alonso, Francisco; Costa-Garcı́a, Agustı́n

doi:10.1002/9781118530009.ch6

Cited by 1 publication

(1 citation statement)

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“…These ions drag the surrounding fluid with them, inducing an EOF that has a flat flow profile as opposed to hydrodynamic flow, which has a parabolic profile. The variable μ eof can be mathematically represented by Equation 5 (93):…”

Section: Electrophoresismentioning

confidence: 99%

Separation Phenomena in Tailored Micro- and Nanofluidic Environments

Sonker

Kim

Egatz-Gómez

et al. 2019

Annual Rev. Anal. Chem.

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Separations of bioanalytes require robust, effective, and selective migration phenomena. However, due to the complexity of biological matrices such as body fluids or tissue, these requirements are difficult to achieve. The separations field is thus constantly evolving to develop suitable methods to separate biomarkers and fractionate biospecimens for further interrogation of biomolecular content. Advances in the field of microfabrication allow the tailored generation of micro- and nanofluidic environments. These can be exploited to induce interactions and dynamics of biological species with the corresponding geometrical features, which in turn can be capitalized for novel separation approaches. This review provides an overview of several unique separation applications demonstrated in recent years in tailored micro- and nanofluidic environments. These include electrokinetic methods such as dielectrophoresis and electrophoresis, but also rather nonintuitive ratchet separation mechanisms, continuous flow separations, and fractionations such as deterministic lateral displacement, as well as methods employing entropic forces for separation.

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Section: Electrophoresismentioning

confidence: 99%