The biggest trigger for the students’ in mastering vocabulary is learning media. The inexistence of good learning media will affect the students’ vocabulary mastery. One of the learning media that is much promoted and used during the pandemic of Covid-19 is the telegram application. Therefore, this research aims to measure the use of telegram applications as learning media to enhance the students’ vocabulary mastery. In this research, the researcher applied a quasi-experimental method. The population of this research was the seventh-grade students at UPTD SMP Negeri 22 Barru. The samples of the research were taken using the cluster random sampling technique, there are two classes as samples, experimental class, and control class, both classes consisted of 28 students. The data was collected using vocabulary tests (pre-test and post-test) and analyzed employing statistical calculations to test the hypothesis. The result of this research shows that the mean score for pre-tests was 45.35 and the post-test was 83.57. Besides the different scores for pre-test and post-test, the mean score of the students in post-test was 83.57 is higher than the Kriteria Ketuntasan Minimal (75) in UPTD SMP Negeri 22 Barru. The result of the t-test value in the post-test was 2.214 and the t-table value was 1.684. It means that H1 was accepted and H0 was rejected and the seventh-grade students at UPTD SMP Negeri 22 Barru who are taught by using the telegram application have better vocabulary mastery than the seventh-grade students who are taught without using the telegram application.