In this study, Taguchi design method supported by analysis of variance (ANOVA) was used to determine the optimum values of motor variables corresponding to optimum motor output. For the design, 1-heptanol ratio (HR), compression ratio (CR) and engine load were selected as engine variables, while the resulting brake thermal efficiency (BTE) and brake specific fuel consumption (BSFC) were selected as engine responses. Among the engine variables, three different values were selected as 0%, 5% and 15% for HR, 6.0:1, 8.0:1 and 10.0:1 for CR, 9, 18 and 27 Nm for load. According to the results, the optimum engine operating parameters required to obtain the best BTE and BSFC values were found to be 5% HR, 10.0:1 CR and 27 Nm load. BTE and BSFC based on optimum operating parameters were found to be 33.120% and 0.278 kg/kWh, respectively. When the results obtained from the optimization and the experimental results were compared, it was revealed that the optimization was successfully performed with an error of less than 10%.