Improving the yield of graphene oxide-catalysed N-heterocyclization of amines through fed batch mode

Abstract

The use of graphene oxide, a metal-free, heterogeneous carbocatalyst for a facile, efficient, and simple protocol for n-heterocyclization of aromatic amines with dihaloalkane to give azacycloalkanes and isolindolines was studied....

Construction of N-Aryl-Substituted Pyrrolidines by Successive Reductive Amination of Diketones via Transfer Hydrogenation

“…As such, a variety of methods for constructing these compounds have been designed and developed for this purpose [ 8 ]. The amination of aromatic amines with dihalogenated compounds [ 9 , 10 , 11 , 12 ] or diols [ 13 , 14 , 15 ] was perceived as a prevalent classical method for pyrrolidine synthesis. Additionally, reductive amination is also one of the general strategies for building N -aryl-substituted pyrrolidines [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ].…”