Improvising PRP for use in osteoarthritis knee- upcoming trends and futuristic view

Dhillon, Mandeep Singh; Patel, Sandeep; Bansal, Tungish

doi:10.1016/j.jcot.2018.10.005

Cited by 36 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although, in our study, grade II OA knee flexion did not improve except in the patients who received a total of four PRP injections, the overall pain decreased in all grade II groups. This finding is directly in line with Dhillon et al's conclusion that PRP injections are an effective treatment for early-stage knee OA symptoms [ 28 ].…”

Section: Discussionsupporting

confidence: 89%

Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study

Hegaze

Hamdi

Alqrache

et al. 2021

Cureus

View full text Add to dashboard Cite

Background Osteoarthritis (OA) is a degenerative disease commonly affecting the knee joints. It affects patients socially, psychologically and economically and rates of the disease have been increasing due to obesity and old age. Regardless of choosing a medically conservative approach, it is a challenge in the long term to provide OA patients efficient treatment with minimal side effects and long-term efficiency. Platelet-rich plasma (PRP) is a convenient, low-cost and affordable treatment technique used in treating knee OA with encouraging efficient and safe outcomes. In this study we will investigate the effect of PRP on knee OA. Methods This is a prospective cohort study involving 252 patients with different OA grades. The Kellgren and Lawrence (K&L) system was used in classifying the affected knee by degenerative cartilage lesions as well as early and severe OA. All patients with a diagnosis of knee OA were screened in every visit before the injection, the pain was assessed by the 0-10 Numeric Rating Scale (NRS), and knee range of motion including flexion and extension was assessed by goniometer. Follow-up appointments were done on three-month intervals for a total of three visits for evaluation. Injection of PRP was given to all the patients with a maximum of four injections. The results were evaluated statistically according to the total number of followup visits. Results In grade II patients, the pain improved with the visits and the maximum improvement in flexion degree was noticed in patients who came for a total of three follow-up visits. In grade III patients, the most improvement in pain was in patients who came for three follow-up visits, while the most improvement in flexion degree was in patients who came for a total of two follow-up visits. Patients with grade IV who came for three follow-up visits showed the most improvement in pain and degree of flexion. Conclusions Intra-articular injections gave significant pain and flexion improvement in grades II, III and IV in OA patients, especially with multiple injection in the short-term follow-up. As a result, recommendation of repeated multiple injections up to four times is efficient in providing long time relief in knee OA.

show abstract

Section: Discussionsupporting

confidence: 89%

Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study

Hegaze

Hamdi

Alqrache

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…These approaches exploit the release of chemo-attractive, angiogenic, proliferative, and putatively pro-regenerative growth factors from PRP, making it suitable as a cell delivery vehicle [36]. The difficulty of controlling the growth factor and cytokine release in PRP makes it necessary to combine it with other molecules, mainly polyethylene glycol (PEG) or chitosan, in order to regulate this [30,33,34,[37][38][39]. Although PRP has shown its potency and capability in tissue regeneration, its experimental inconsistency and low reproducibility has meant that, in applications in which platelet-released growth factors are not crucial, PPP is generally used.…”

Section: Introductionmentioning

confidence: 99%

Effect of Fibrin Concentration on the In Vitro Production of Dermo-Epidermal Equivalents

Montero

Quílez

Valencia

et al. 2021

IJMS

View full text Add to dashboard Cite

Human plasma-derived bilayered skin substitutes were successfully used by our group to produce human-based in vitro skin models for toxicity, cosmetic, and pharmaceutical testing. However, mechanical weakness, which causes the plasma-derived fibrin matrices to contract significantly, led us to attempt to improve their stability. In this work, we studied whether an increase in fibrin concentration from 1.2 to 2.4 mg/mL (which is the useful fibrinogen concentration range that can be obtained from plasma) improves the matrix and, hence, the performance of the in vitro skin cultures. The results show that this increase in fibrin concentration indeed affected the mechanical properties by doubling the elastic moduli and the maximum load. A structural analysis indicated a decreased porosity for the 2.4 mg/mL hydrogels, which can help explain this mechanical behavior. The contraction was clearly reduced for the 2.4 mg/mL matrices, which also allowed for the growth and proliferation of primary fibroblasts and keratinocytes, although at a somewhat reduced rate compared to the 1.2 mg/mL gels. Finally, both concentrations of fibrin gave rise to organotypic skin cultures with a fully differentiated epidermis, although their lifespans were longer (25–35%) in cultures with more concentrated matrices, which improves their usefulness. These systems will allow the generation of much better in vitro skin models for the testing of drugs, cosmetics and chemicals, or even to “personalized” skin for the diagnosis or determination of the most effective treatment possible.

show abstract

“…Thus, in addition to its anti-inflammatory effects, PRP may also have potential analgesic effects. Experimental studies have shown that in OA, PRP also affects synoviocytes, endothelial cells, and cells involved in cellular immunity (e.g., macrophages) [186,187]. Additionally, it has been shown that the concentration of growth factors, such as PDGF, β-FGF, VEGF, and IGF-1 increases at various time points within 96 h after the injection of PRP.…”

Section: Prp As Source Of Cytokinesmentioning

confidence: 99%

Overview of First-Line and Second-Line Pharmacotherapies for Osteoarthritis with Special Focus on Intra-Articular Treatment

Nowaczyk

Szwedowski

Dallo³

et al. 2022

IJMS

View full text Add to dashboard Cite

Osteoarthritis (OA) can be defined as the result of pathological processes of various etiologies leading to damage to the articular structures. Although the mechanism of degenerative changes has become better understood due to the plethora of biochemical and genetic studies, the drug that could stop the degenerative cascade is still unknown. All available forms of OA therapy are based on symptomatic treatment. According to actual guidelines, comprehensive treatment of OA should always include a combination of various therapeutic options aimed at common goals, which are pain relief in the first place, and then the improvement of function. Local treatment has become more common practice, which takes place between rehabilitation and pharmacological treatment in the hierarchy of procedures. Only in the case of no improvement and the presence of advanced lesions visible in imaging tests, should surgery be considered. Currently, an increasing number of studies are being published suggesting that intra-articular injections may be as effective or even more effective than non-steroidal anti-inflammatory drugs (NSAIDs) and result in fewer systemic adverse events. The most commonly used preparations are hyaluronic acid (HA), glucocorticosteroids (GS), and also platelet-rich plasma (PRP) in recent years. This review aims to present the mechanism of action and clinical effectiveness of different pharmacological options in relieving pain and improving functions in OA as well as the emerging approach in intra-articular treatment with PRP.

show abstract

Improvising PRP for use in osteoarthritis knee- upcoming trends and futuristic view

Cited by 36 publications

References 40 publications

Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study

Efficacy of Platelet-Rich Plasma on Pain and Function in the Treatment of Knee Osteoarthritis: A Prospective Cohort Study

Effect of Fibrin Concentration on the In Vitro Production of Dermo-Epidermal Equivalents

Overview of First-Line and Second-Line Pharmacotherapies for Osteoarthritis with Special Focus on Intra-Articular Treatment

Contact Info

Product

Resources

About