Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs

Coleridge, H. M.; Coleridge, J. C. G.

doi:10.1016/0034-5687(77)90086-x

Cited by 216 publications

(129 citation statements)

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“…Blood pressure decreased dramatically while little or no changes were observed in nerve activity or intratracheal pressure. SENSORY RECEPTORS IN THE RAT LUNG the range reported for C fibres in the cat (Paintal, 1957(Paintal, , 1973 and dog (Coleridge, Coleridge & Luck, 1965;Coleridge & Coleridge, 1977). The base-level activity of C fibres during the ventilation approximating eupnoeic conditions was 90+84 impulses min1 and is similar to that reported for those in the dog (Kappagoda, Mah & Teo, 1987;Jonzon, Pisarri, Roberts, Coleridge & Coleridge, 1988) responded to stepwise and constant-pressure inflations of the lungs, but the response was weak even at high intratracheal pressures (3-4 x tidal volume or 30-40 cmH20).…”

Section: Resultsmentioning

confidence: 92%

“…However, little is known about the afferent properties of pulmonary receptors in this species. Studies of pulmonary afferent endings in dogs (Sampson & NIS 9906 D. R. BERGREiN AND D. F. PETERSON Vidruk, 1975;Coleridge & Coleridge, 1977), cats (Knowlton & Larrabee, 1946;Widdicombe, 1954;Paintal, 1957) and rabbits (Mills, Sellick & Widdicombe, 1969) have been largely responsible for the establishment of the categories of pulmonary receptors. Presently there are but three accepted categories of pulmonary sensory receptors; slowly adapting receptors (SARs), rapidly adapting receptors (RARs) and C fibre endings, both pulmonary and bronchial (Paintal, 1973; Sampson, 1977; Coleridge Widdicombe, 1986).…”

Section: Introductionmentioning

confidence: 99%

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Identification of vagal sensory receptors in the rat lung: are there subtypes of slowly adapting receptors?

Bergren

Peterson

1993

The Journal of Physiology

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SUMMARY1. We studied the characteristics of pulmonary sensory receptors whose afferent fibres are in the left vagus nerve of opened-chest rats. The activity of these receptors was recorded during mechanical ventilation approximating eupnoea, as well as during deflation, stepwise inflations and constant-pressure inflations of the lungs. Data were also collected from closed-chest rats and analysed separately.2. Ninety-four per cent of receptors were located in the ipsilateral lung or airways with the remainder in the contralateral lung.3. Not only were slowly adapting receptors (SARs) the most abundant pulmonary receptors but 21 % of them were either exclusively or predominantly active during the deflationary phase of the ventilatory cycle. Deflationary units were found in opened-and closed-chest rats. The average conduction velocity for all fibres innervating SARs averaged 29-7 m s-'. 4. We found rapidly adapting receptors (RARs) to be extremely rare in the rat. Their activity was sparse and irregular. The conduction velocities of fibres innervating RARs averaged 12 3 m s-'.5. Far more abundant than RARs in the remaining population of pulmonary fibres were C fibres. They were observed to have an average conduction velocity of 2-1 m s-1, base-level activity which was irregular and a high pressure threshold of activation and were stimulated by intravenous capsaicin injection.6. Notable differences exist between pulmonary receptors in rats and those reported in other species. The variations include the abundant existence of intrapulmonary SARs with exclusively deflationary modulation and the rarity of RARs. We also encountered C fibres which have not previously been described systematically in the rat.

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Section: Resultsmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Identification of vagal sensory receptors in the rat lung: are there subtypes of slowly adapting receptors?

Bergren

Peterson

1993

The Journal of Physiology

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“…), and some by the conduction velocities of their fibres. Conduction velocity was measured according to the method of Coleridge & Coleridge (1977). Finally all endings used in the study were located in the lung by mechanical stimulation.…”

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confidence: 99%

The Action of Sodium Cromoglycate on ‘C’ Fibre Endings in the Dog Lung

Dixon¹,

Jackson²,

Richards³

1980

British J Pharmacology

187

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“…In addition, it has been proposed that nedocromil sodium inhibits sensory nerve activation since it reduces, for example, S02- (Altounyan et al, 1986) and bradykinin- (Barnes, 1986) induced reflex bronchoconstriction in man and citric acidinduced cough in dogs (Jackson, 1988). The activation of sensory nerves in the airways by histamine (Coleridge & Coleridge, 1977) and bradykinin (Kaufman et al, 1980) is now well recognized and has also been shown to result in the release of sensory neuropeptides like substance P (Saria et al, 1988). Capsaicin specifically stimulates sensory nerves (see Buck & Burks, 1986), but may do so by a mechanism different from that seen with bradykinin, since capsaicin-induced reflex bronAuthor for correspondence.…”

Section: Introductionmentioning

confidence: 99%

Effect of nedocromil sodium on allergen‐, PAF‐, histamine‐ and bradykinin‐induced airways vasodilatation and pulmonary obstruction in the pig

Alving

Matran

Lundberg

1991

British J Pharmacology

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1 The influence of nedocromil sodium on the nasal and bronchial effects induced by allergen, plateletactivating factor (PAF), capsaicin, histamine and bradykinin aerosol challenge in ascaris-sensitized and pentobarbitone-anaesthetized pigs was studied. Blood flow changes in the bronchial and nasal circulation were measured with ultrasonic flow probes around the supplying arteries, and vascular resistance was calculated. Changes in pulmonary resistance (Rpul.), dynamic compliance (Cdy.), mean arterial pressure (MAP) and heart rate (HR) were also determined. 2 Allergen and PAF aerosol challenge in the lung produced similar effects consisting of both bronchial and nasal vasodilatation, bronchoconstriction (increase in Rpuim and decrease in CdY,) and increases in MAP and HR. Local pretreatment with nedocromil sodium (80mg, aerosol) reduced the peak and duration of both the bronchial vasodilatation and increase in Rpuim, while only the duration of the change in Cdyn was significantly decreased. Nedocromil sodium did not alter the increases in MAP and HR. The nasal vasodilatation evoked by PAF, but not allergen, challenge in the lung was reduced by nedocromil sodium. 3 Allergen challenge in the nose induced vasodilatation of long duration which was reduced by local nedocromil sodium pretreatment (50,pg kg-1, intra-arterially). 4 The vasodilator response to histamine aerosol was attenuated in the nasal, but not the bronchial circulation by local nedocromil sodium pretreatment. Histamine-induced bronchoconstriction was not altered by nedocromil sodium. 5 Bradykinin aerosol-induced vasodilatation in the nasal and bronchial circulation was markedly and equally reduced by local nedocromil sodium and systemic capsaicin (50mgkg-1, s.c. 2 days before) pretreatment. The vasodilatation caused by i.v. bradykinin challenge was not reduced by capsaicin pretreatment. Capsaicin aerosol-induced vasodilatation in the nasal and bronchial circulation was not affected by local nedocromil sodium pretreatment. 6 In conclusion, nedocromil sodium blocks some local vascular and bronchial effects, but not increases in MAP and HR, induced by allergen and PAF aerosol in the pig. Bradykinin-induced vasodilatation in the airways, which seems to be largely dependent on capsaicin-sensitive sensory nerves, is markedly inhibited by nedocromil sodium pretreatment, whereas capsaicin-induced vasodilatation is not affected by nedocromil sodium. It may be suggested that nedocromil sodium acts by inhibiting some common process involved in the release of mediators from inflammatory cells (when stimulated by allergen and PAF) and sensory nerves (when stimulated by bradykinin and histamine, but not capsaicin).

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Impulse activity in afferent vagal C-fibres with endings in the intrapulmonary airways of dogs

Cited by 216 publications

References 20 publications

Identification of vagal sensory receptors in the rat lung: are there subtypes of slowly adapting receptors?

Identification of vagal sensory receptors in the rat lung: are there subtypes of slowly adapting receptors?

The Action of Sodium Cromoglycate on ‘C’ Fibre Endings in the Dog Lung

Effect of nedocromil sodium on allergen‐, PAF‐, histamine‐ and bradykinin‐induced airways vasodilatation and pulmonary obstruction in the pig

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