Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update

Voon, Valerie; Napier, T. Celeste; Frank, Michael J.; Sgambato-Faure, Véronique; Grace, Anthony A.; Rodriguez-Oroz, María C.; Obeso, José A.; Bézard, Erwan; Fernagut, Pierre‐Olivier

doi:10.1016/s1474-4422(17)30004-2

Cited by 308 publications

(242 citation statements)

References 138 publications

(126 reference statements)

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“…The mechanisms underlying the development of LIDs are still a matter of investigation 1. Our findings support the hypothesis that motor (LIDs) and non-motor (addiction) hyper-dopaminergic states share common pathophysiological mechanisms 2. Higher frequency of the A allele of OPRK1_c.271G>T has been associated with addictive disorders4,(,e-2) through a modulation of stress-related activation of the κ-opioid peptide (KOP) receptors within the ventral striatum.…”

supporting

confidence: 79%

Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinson’s disease

Cilia

Asselta

Cereda

et al. 2017

J Neurol Neurosurg Psychiatry

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supporting

confidence: 79%

Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinson’s disease

Cilia

Asselta

Cereda

et al. 2017

J Neurol Neurosurg Psychiatry

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“…There might be many reasons for this result. Firstly, from common risk factor perspective, both ICRDs and dyskinesia might be affected by excessive dopaminergic drug stimulation, earlier onset of the disease and severe cognitive impairment [13, 14]. Secondly, from pathophysiology perspective, both ICRDs and dyskinesia might be induced by excessive stimulation in the motor or limbic territories of the striatum.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of impulse control and related disorders in Chinese Parkinson’s disease patients

Lin

Chen

et al. 2017

BMC Neurol

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BackgroundImpulse control and related disorders (ICRDs) are clinically complications in Parkinson’s disease (PD). However, the clinical characteristics of ICRDs in Chinese PD patients were rarely reported. We aimed to explore the prevalence and the clinical profile of ICRDs in Chinese patients with PD.Methods142 Chinese PD patients were consecutively enrolled. The symptoms of ICRDs were assessed with the Questionnaire for Impulsive-Compulsive Disorders. The clinical characteristics of patients with ICRDs and without ICRDs were compared.ResultsICRDs were present in 31% of our patients. The most common ICRDs were compulsive medication use (11.3%) and punding (9.2%); the least frequent were walkabout (1.4%). Variables independently associated with ICRDs were earlier onset of the disease (≤55 years), severe cognitive impairment (MMSE 10–20), the dose of dopamine agonist (>1 mg/d) and dyskinesia.ConclusionsICRDs was commonly found in Chinese PD patients. Earlier onset of the disease, the dose of dopamine agonist, severe cognitive impairment and dyskinesia are independent factors associated with ICRDs. Our results will be benefit for clinicians to assess the risk of developing ICRDs before delivering dopaminergic medication.

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“…Studies in both medicated PD patients (e.g., Cools et al 2006; Muhammed et al 2016; Van Wouwe et al 2017) and animal models (Cocker et al 2017; Johnson et al 2011; Rokosik and Napier 2012; Tremblay et al 2017) have shown the impulsivity inducing effects of dopaminergic therapy. Nevertheless, the effects seems to depend on certain cllinical and neural characteristics (e.g., baseline dopamine levels) (Claassen et al 2011; Cools and D’Esposito 2011) and on the type of task (Voon et al 2017). For a more thorough review on the effects of dopamine replacement therapy on impulsive behavior in PD see Voon et al (2017).…”

Section: Dopaminementioning

confidence: 99%

“…Nevertheless, the effects seems to depend on certain cllinical and neural characteristics (e.g., baseline dopamine levels) (Claassen et al 2011; Cools and D’Esposito 2011) and on the type of task (Voon et al 2017). For a more thorough review on the effects of dopamine replacement therapy on impulsive behavior in PD see Voon et al (2017). Nevertheless, although these studies show that dopaminergic medication precipitates impulsive behavior in PD patients, their use does not seem sufficient to cause clinically significant ICD.…”

Section: Dopaminementioning

confidence: 99%

“…This suggests that the effects of the PD pathology on the dopamine system do play a role in ICD development. ICD subtypes and different aspects of impulse control might be differentially affected by dopamine degeneration and dopamine suppletion (see Voon et al 2017 for a review).

Fig. 1Illustrative summary of putative neurobiological mechanisms for ICD development.…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

See 1 more Smart Citation

The neurobiology of impulse control disorders in Parkinson’s disease: from neurotransmitters to neural networks

Vriend

2018

Cell Tissue Res

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Impulse control disorders (ICD) are common neuropsychiatric disorders that can arise in Parkinson’s disease (PD) patients after commencing dopamine replacement therapy. Approximately 15% of all patients develop these disorders and many more exhibit subclinical symptoms of impulsivity. ICD is thought to develop due to an interaction between the use of dopaminergic medication and an as yet unknown neurobiological vulnerability that either pre-existed before PD onset (possibly genetic) or is associated with neural alterations due to the PD pathology. This review discusses genes, neurotransmitters and neural networks that have been implicated in the pathophysiology of ICD in PD. Although dopamine and the related reward system have been the main focus of research, recently, studies have started to look beyond those systems to find new clues to the neurobiological underpinnings of ICD and come up with possible new targets for treatment. Studies on the whole-brain connectome to investigate the global alterations due to ICD development are currently lacking. In addition, there is a dire need for longitudinal studies that are able to disentangle the contributions of individual (genetic) traits and secondary effects of the PD pathology and chronic dopamine replacement therapy to the development of ICD in PD.

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Impulse control disorders and levodopa-induced dyskinesias in Parkinson's disease: an update

Cited by 308 publications

References 138 publications

Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinson’s disease

Opioid K receptor variant is associated with a delayed onset of dyskinesias in Parkinson’s disease

Clinical characteristics of impulse control and related disorders in Chinese Parkinson’s disease patients

The neurobiology of impulse control disorders in Parkinson’s disease: from neurotransmitters to neural networks

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