Impulse control disorders in Parkinson's disease: A 20‐year odyssey

Weintraub, Daniel

doi:10.1002/mds.27668

Cited by 29 publications

(23 citation statements)

References 60 publications

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“…Consider, for example, ADHD, where symptoms of inattention and impulsivity are often treated with dopamine-enhancing drugs like methylphenidate. Conversely, consider PD, where dopamine-enhancing medication can actually, in a considerable proportion of patients, contribute to cognitive deficits, leading, in some cases, to severe psychiatric abnormalities, including gambling addiction, hypersexuality, compulsive hobbying, and/ or addiction to medication intake (Weintraub, 2019). More pertinent, perhaps, are the diametrically opposite effects seen with the same drug administered to the same individuals across different tasks.…”

Section: Dopaminergic Drug Effects On Human Cognitionmentioning

confidence: 99%

Chemistry of the Adaptive Mind: Lessons from Dopamine

Cools

2019

Neuron

125

114

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The brain faces various computational tradeoffs, such as the stability-flexibility dilemma. The major ascending neuromodulatory systems are well suited to dynamically regulate these tradeoffs depending on changing task demands. This follows from various general principles of chemical neuromodulation, which are illustrated with evidence from pharmacological neuroimaging studies on striatal dopamine's role in output gating and cost-benefit choice of cognitive tasks. The work raises open questions, including those regarding the top-down cortical control of the midbrain dopamine system, and begins to elucidate the mechanisms underlying the variability in catecholaminergic drug effects. Such drug effects depend on the baseline state of distinct target brain regions, reflecting, in part, the systems' self-regulatory capacity to maintain equilibrium. It is hypothesized that the basal tone of different dopaminergic projection systems reflects the perceived statistics of the environment computed in frontal cortex. By normalizing dopamine levels, dopaminergic drugs might counteract the bias elicited by the perceived environment.

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Section: Dopaminergic Drug Effects On Human Cognitionmentioning

confidence: 99%

Chemistry of the Adaptive Mind: Lessons from Dopamine

Cools

2019

Neuron

125

114

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“…Although non-strategic decision-making is more common in men with PD than in women [11,[109][110][111][112], both sexes may exhibit risk-taking behaviors (e.g., pathological gambling, compulsive buying, etc.) while temporal discounting (e.g., inability to delay gratification) is more associated with men than women [6,11,[109][110][111]113]. In PD populations, although both sexes may exhibit some non-strategic decision-making [77,78,113], there remains a need to determine the extent to which this cognitive domain influences clinical outcomes in men compared to women.…”

Section: Do Men and Women With Pd Perform The Igt Differently?mentioning

confidence: 99%

Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson’s Disease?

Salvatore

Soto

Alphonso

et al. 2021

JPD

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Up to 23% of newly diagnosed, non-demented, Parkinson’s disease (PD) patients experience deficits in executive functioning (EF). In fact, EF deficits may occur up to 39-months prior to the onset of motor decline. Optimal EF requires working memory, attention, cognitive flexibility, and response inhibition underlying appropriate decision-making. The capacity for making strategic decisions requires inhibiting imprudent decisions and are associated with noradrenergic and dopaminergic signaling in prefrontal and orbitofrontal cortex. Catecholaminergic dysfunction and the loss of noradrenergic and dopaminergic cell bodies early in PD progression in the aforementioned cortical areas likely contribute to EF deficits resulting in non-strategic decision-making. Thus, detecting these deficits early in the disease process could help identify a significant portion of individuals with PD pathology (14–60%) before frank motor impairment. A task to evaluate EF in the domain of non-strategic decision-making might be useful to indicate the moderate loss of catecholamines that occurs early in PD pathology prior to motor decline and cognitive impairment. In this review, we focus on the potential utility of the Iowa Gambling Task (IGT) for this purpose, given significant overlap between in loss of dopaminergic and noradrenergic cells bodies in early PD and the deficits in catecholamine function associated with decreased EF. As such, given the loss of catecholamines already well-underway after PD diagnosis, we evaluate the potential utility of the IGT to identify the risk of therapeutic non-compliance and a potential companion approach to detect PD in premotor stages.

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“…The neural substrate of ICDs and increased impulsivity in PD is thought to involve dysregulation in mesolimbic and mesocortical networks, and changes in dopamine receptor (D2 and D3) binding in the ventral striatum [5, 11], but specific neuropathological correlates have not been identified. However, based on the disease staging studies by Braak et al, it might be envisaged that changes in impulsivity could correlate with Stage V, in which the Lewy pathology extends to the mesolimbic cortex, and could precede, or overlap with, the development of impaired cognition, as there is further extension to neocortical areas in Stage VI of the disease [12].…”

Section: Introductionmentioning

confidence: 99%

“…A link between impulsive traits and low cognitive scores has been observed in other cohorts, such as children with attention-deficit hyperactive disorder (ADHD) [13]. In addition, preliminary evidence suggests that, in PD, cognitive characteristics such as poor executive abilities, as well as poor action control and response inhibition, and certain personality traits such as negative affectivity and high premorbid levels of novelty seeking, may have impact on impulsivity and be risk factors for the development of ICDs [6, 11, 14]. However, relatively little is known about the link between cognitive abilities and behavioral changes in patients with PD, and there have been conflicting findings in the literature [15–17].…”

Section: Introductionmentioning

confidence: 99%

Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort

Jeyadevan

Bakeberg

Byrnes

et al. 2019

Parkinson's Disease

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Introduction Patients with Parkinson's disease (PD) commonly experience cognitive deficits and some also develop impulse control disorders (ICDs); however, the relationship between impulsivity and cognitive dysfunction remains unclear. This study investigated whether trait impulsivity associates with mild cognitive impairment (MCI), or is altered in a PD patient cohort with MCI. Methods A total of 302 patients with idiopathic PD were recruited sequentially from three Australian Movement Disorder clinics. Based on cognitive scores, participants were divided into two groups, one defined as having mild cognitive impairment (PD-MCI; n = 113) and the other with normal cognitive function (PD-C; n = 189). Trait impulsivity was evaluated using the Barrett Impulsiveness Scale 11 (BIS-11). Total impulsivity scores, as well as subscale scores, were compared between PD-C and PD-MCI groups. Results The PD-MCI cohort had significantly lower scores in all cognitive domains, and mirrored expected clinical differences in medication, motor symptoms, and disease duration, when compared to the PD-C cohort. Self-reported impulsivity was not significantly different between groups, nor was there a difference within first-order subscale scores: attention (p=0.137), cognitive instability (p=0.787), self-control (p=0.503), cognitive complexity (p=0.157), motor impulsivity (p=0.559), or perseverance (p=0.734) between the PD-MCI and PD-C groups. Conclusions These findings suggest that impulsive traits and behaviors are independent of changes in cognitive state and are not altered in PD patients with mild cognitive impairment.

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Impulse control disorders in Parkinson's disease: A 20‐year odyssey

Cited by 29 publications

References 60 publications

Chemistry of the Adaptive Mind: Lessons from Dopamine

Chemistry of the Adaptive Mind: Lessons from Dopamine

Is there a Neurobiological Rationale for the Utility of the Iowa Gambling Task in Parkinson’s Disease?

Trait Impulsivity Is Independent of Mild Cognitive Impairment in a Parkinson’s Disease Cohort

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