Impulse generation in type I cutaneous mechanoreceptors.

Horch, K.W.; Whitehorn, David; Burgess, P. R.

doi:10.1152/jn.1974.37.2.267

Cited by 107 publications

(59 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If they do indeed originate from muscle spindles, it is possible that the recorded discharges are impulses conducted antidromically in branches of the parent axon to the spindle. Most sensory axons subserving various sensory modalities have branchings close to their receptors (Lindblom, 1958;Millar, 1971;Duclaux & Kenshalo, 1973;Floyd & Morrison, 1974;Horch, Whitehorn & Burgess, 1974; Matthews, 1977;Fukami, 1980). However, the T. KATO, Y. KAWAMURA AND T. MORIMOTO afferents to the sensory endings in the mammalian muscle spindles, especially Ia fibres to the primary ending, rarely branch prior to entering the capsule of individual spindles (for review, Matthews, 1972;Barker, 1974).…”

Section: Introductionmentioning

confidence: 99%

Branching of muscle spindle afferents of jaw closing muscles in the cat.

Kato¹,

Kawamura²,

Morimoto³

1982

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Functionally isolated single fibres were prepared from the cut central ends of the masseter nerve in cats. Of those firing in response to muscle stretch, most were alpha motor units but some had the properties of afferent fibres innervating muscle receptors.2. These afferent units were remarkably sensitive to muscle stretch even under anaesthesia deep enough to eliminate all stretch evoked e.m.g. activity in masseter. Moreover, these units responded to gentle pressing of the surface of either the masseter, temporalis or pterygoid muscles.3. On the basis of their responses to ramp stretch, to high-frequency vibration, to suxamethonium, and to gentle pressing of the muscle surface, the majority were considered to arise from primary or secondary endings of muscle spindles.4. In reflexly induced jaw movements, the highest discharge frequency of these spindles was observed during the jaw opening phase. However, they were also activated during the jaw closing phase, indicating that the fusimotor innervation to the source spindle was still preserved.5. From these results, it is concluded that branching of the spindle afferent outside the capsule occurs in the muscle nerve innervating cat's jaw closing muscles.

show abstract

Section: Introductionmentioning

confidence: 99%

Branching of muscle spindle afferents of jaw closing muscles in the cat.

Kato¹,

Kawamura²,

Morimoto³

1982

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…The nerve strands were placed on Ag-AgCl hook electrodes and single-unit recordings were made from afferent fibres supplying slowly adapting mechanoreceptors in the skin of the anterior aspect of the lower leg. Type I units were identified by their characteristic discharge in response to maintained mechanical stimulation of discrete spots in the skin only (Iggo & Muir, 1969;Horch, Whitehorn & Burgess, 1974) whereas type II units could also be excited by dermal stretch (Chambers et al 1972).…”

Section: Experiments On Catsmentioning

confidence: 99%

“…At this time the responses 540 SLOWLY ADAPTING MECHANORECEPTORS IN THE SKIN 541 were close to steady state. Full adaptation of both types of slowly adapting receptors requires more than 10 s (Chambers et al 1972;Horch et al 1974 In SAII receptors the regularity of the receptor discharge was maintained under the action of neomycin with only a slight increase in the coefficient of variance, e.g. from 0-34 to 0-38 (see Fig.…”

Section: Rat Slowly Adapting Type II Receptorsmentioning

confidence: 99%

Acute effects of neomycin on slowly adapting type I and type II cutaneous mechanoreceptors in the anaesthetized cat and rat.

Baumann

Hamann

Leung

1990

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Slowly adapting type I (SAI) and type IL (SAII) mechanoreceptors in the skin were studied in anaesthetized cats and rats employing mechanical stimuli every 30 s. Individual stimuli rose within 200 ms to a plateau force which was kept constant through a feedback control unit for 2000 ms.2. In cats, close arterial infusion of neomycin (2-5 mg/min) as sulphate was given through a side branch into the femoral blood stream for 5, 10 or 20 min at a rate of 0-025 ml/min. At other times saline was infused at the same rate.3. After 20 min of neomycin infusion (total 50 mg) nervous discharge of cat SAI receptors was suppressed to about 30% of the control responses before neomycin infusion. Nervous responses were reduced more profoundly during the plateau phase of stimulation than during the dynamic phase. The interspike interval histogram was severely distorted.4. In contrast, cat SAII receptors maintained about 70 % of their control response after 20 min of neomycin infusion. The interspike interval histogram showed an orderly shift towards longer intervals maintaining its normal shape.5. In rats, intradermal microinfusion of neomycin (30 jzg/min) through a glass micropipette into the immediate vicinity of the receptor under investigation resulted in severe transient suppression of SAI receptor responses to about 10 % of the control level. Receptor responses recovered almost completely about 1 h after the end of neomycin application.6. It is concluded that the observed differences between the two types of slowly adapting mechanoreceptors are consistent with the hypothesis that the SAI receptor functions as a secondary sensory receptor, with a synaptic link between the Merkel cell and the primary afferent neurone.

show abstract

“…For this reason, time correlations were introduced, similar to those observed in current for spinal sensory neurons [42]. Noise was added to the transduction function due to the assumption that variable inter spike intervals result from synaptic transmission from Merkel cells giving rise to noisy input to spike initiation [38]. While the modeled transduction function is linear, the true stimulus-current transformation is likely sigmoidal, as observed for nociceptors and hair cells [43] [44].…”

Section: Methodsmentioning

confidence: 99%

“…Although of great interest, these differences have yet to be attributed to a particular biological variation, such as skin mechanics [35], the number of Merkel cell-neurite complexes innervated by an SAI afferent [36][37] [38], or the structure of the SAI afferent's end organ [8].…”

Section: Introductionmentioning

confidence: 99%

The Stimulus-Response Transformation of the SAI Tactile Afferent is Modulated by the Number and Arrangement of Merkel Cells in its Compound End Organ

Lesniak¹

View full text Add to dashboard Cite

Impulse generation in type I cutaneous mechanoreceptors.

Cited by 107 publications

References 0 publications

Branching of muscle spindle afferents of jaw closing muscles in the cat.

Branching of muscle spindle afferents of jaw closing muscles in the cat.

Acute effects of neomycin on slowly adapting type I and type II cutaneous mechanoreceptors in the anaesthetized cat and rat.

The Stimulus-Response Transformation of the SAI Tactile Afferent is Modulated by the Number and Arrangement of Merkel Cells in its Compound End Organ

Contact Info

Product

Resources

About