Impulse oscillometry: an alternative modality to the conventional pulmonary function test to categorise obstructive pulmonary disorders

Al-Mutairi, Sana; Sharma, Promila; Al-Alawi, Alia; Al-Deen, J. S.

doi:10.1007/s10238-007-0126-y

Cited by 58 publications

(47 citation statements)

References 36 publications

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“…In this study, FVC, FEV 1 , FEV 1 /FVC, and MMEF decreased in COPD patients compared with healthy controls, which reflected airflow limitations. Among the IOS parameters, Z5, Fres, R5, R20, and R5–R20 increased significantly, and the degree of R5–R20 increase was much higher than the degree of R20 increase, which suggested that in COPD, the increase in peripheral airway resistance was predominant with a certain degree of increase in central airway resistance; this was consistent with other research results 15–17. Under physiological conditions, the ratio of peripheral airway resistance to total airway resistance was 10%–25%, but in COPD patients, the percentage of peripheral airway resistance was greatly increased 14.…”

Section: Discussionsupporting

confidence: 90%

Clinical application value of impulse oscillometry in geriatric patients with COPD

Liu

2017

COPD

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BackgroundThe diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clinical application value of IOS in geriatric patients with COPD remains unclear.AimThe aim of this study was to investigate the clinical application value of IOS in geriatric patients with COPD.Subjects and methodsA total of 234 subjects were retrospectively enrolled in this study, including 133 patients with COPD and 101 healthy volunteers. All the participants underwent IOS and spirometry examination. The data were collected and analyzed in the overall group, the geriatric group (aged ≥65 years), and the advanced elderly group (aged ≥80 years).Results1) In COPD patients, a significant increase in respiratory impedance (Z5), resonant frequency (Fres), and respiratory resistance (R5, R20, R5–R20) and a decrease in respiratory reactance (X5) were observed in the overall group, the geriatric group, and the advanced elderly group compared with the healthy control subjects. 2) The IOS parameters correlated well with spirometry in COPD. In particular, R5–R20 showed the best correlation with forced expiratory volume in 1 second (FEV1) in the different age groups. 3) Fres and R5–R20 had the best diagnostic efficiency for COPD. The area under the curve (AUC) values for Fres, expressed by the receiver operating characteristic (ROC) curve, were 0.905, 0.909, and 0.914, for the different age groups, respectively. 4) The optimal cutoff values for Fres to diagnose airflow obstruction from ROC curves was 17.715 in the COPD patients. Its sensitivity and specificity were 0.789 and 0.931, respectively, and the cutoff values were similar in geriatric and advanced elderly patients.ConclusionIOS demonstrated good relevance compared with spirometry for geriatric patients with COPD. IOS may serve as an alternative method for spirometry in elderly subjects for the evaluation of the state of COPD.

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Section: Discussionsupporting

confidence: 90%

Clinical application value of impulse oscillometry in geriatric patients with COPD

Liu

2017

COPD

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“…Testing was performed using the Jaeger MasterScreen-IOS system (Carefusion Technologies, San Diego, CA, USA). The method has been described in detail elsewhere [19, 20]. In short, pressure impulses were sent from a loudspeaker through the respiratory system.…”

Section: Methodsmentioning

confidence: 99%

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

et al. 2017

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BackgroundBronchopulmonary dysplasia (BPD) is a strong risk factor for respiratory morbidity in children born preterm. Our aims were to evaluate lung function in adolescents born preterm with and without a history of BPD, and to assess lung function change over time from school age.MethodsFifty-one individuals born in Stockholm, Sweden between gestational ages 24 to 31 weeks (23 neonatally diagnosed with respiratory distress syndrome (RDS) but not BPD, and 28 graded as mild (n = 17), moderate (n = 7) or severe (n = 4) BPD) were examined in adolescence (13–17 years of age) using spirometry, impulse oscillometry (IOS), plethysmography, and ergospirometry. Comparison with lung function data from school age (6–8 years of age) was also performed.ResultsAdolescents with a history of BPD had lower forced expiratory volume in 1 s (FEV1) compared to those without BPD (−0.61 vs.-0.02 z-scores, P < 0.05), with lower FEV1 values significantly associated with BPD severity (P for trend 0.002). Subjects with severe BPD had higher frequency dependence of resistance, R5–20, (P < 0.001 vs. non-BPD subjects) which is an IOS indicator of peripheral airway involvement. Between school age and adolescence, FEV1/FVC z-scores decreased in all groups and particularly in the severe BPD group (from −1.68 z-scores at 6–8 years to −2.74 z-scores at 13–17 years, p < 0.05 compared to the non-BPD group).ConclusionsOur results of spirometry and IOS measures in the BPD groups compared to the non-BPD group suggest airway obstruction including involvement of peripheral airways. The longitudinal result of a decrease in FEV1/FVC in the group with severe BPD might implicate a route towards chronic airway obstruction in adulthood.

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“…COPD and asthma studies have shown that IOS measurements are more sensitive than forced expiratory volume in 1 sec (FEV1) for measuring the pulmonary effects of bronchodilator drugs (13)(14)(15). Additionally, IOS measurements can also be used to sensitively diagnose obstructive lung disease (16,17). Thus, the understanding of which IOS measurements are correlated with the degree of airflow obstruction (as measured by FEV1) and which measurements are correlated with the degree of hyperinflation (measured by lung volumes) is required.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of respiratory impedance in patients with chronic obstructive pulmonary disease by an impulse oscillation system

Gong

Yang

Zheng

2014

Molecular Medicine Reports

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An impulse oscillometry system (IOS) assesses pulmonary resistance and reactance. The present study investigated which IOS measurement is correlated with airflow obstruction, airway conductance and lung volume in chronic obstructive pulmonary disease (COPD). A total of 180 patients with COPD were selected and 95 agreed to follow‑up 1 year after the initial tests. IOS measurements [R5, R20, X5 and resonant frequency (Fres)], body plethysmography [forced end‑expiratory flow (FEF)75, total lung capacity, residual volume (RV) and total inspiratory resistance (Rtot)] and spirometry [forced expiratory volume in 1 sec (FEV1)] were performed. Pearson's or Spearman's correlation tests were used to determine the correlation between the IOS and other measurements. R5, X5 and Fres were all significantly associated (P<0.05) with FEV1, FEF75, RV and Rtot. However, R20 was not correlated with these measurements except from FEF75 and Rtot (r values were all<0.25). The strongest associations were observed with FEV1 and the reactance measurements X5 (r=0.635), Fres (r=‑0.721) and R5 (r=‑0.496); FEF75 with X5 (r=0.505), Fres (r=‑0.629) and R5 (r=‑0.468); RV with X5 (r=‑0.485), Fres (r=0.570) and R5 (r=0.326); and Rtot with X5 (r=‑0.691), Fres (r=0.632) and R5 (r=0.570). There was a significant increase in FEV1 and X5 after one year as compared with the RV. The other measurements did not change over the year. The changes in X5, Fres and R5 were significantly correlated with the changes in FEV1 and the correlation coefficients were 0.355, ‑0.364 and ‑0.381, respectively. Similarly, the changes in X5, Fres and R5 were significantly correlated with the changes in RV and the correlation coefficients were ‑0.264, 0.287 and 0.318, respectively. In the COPD patients, the IOS reactance measurements were more closely correlated with other pulmonary function measurements rather than with resistance measurements. The IOS reactance measurements, particularly X5, appear to indicate changes in pulmonary compliance caused by airflow obstruction.

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Impulse oscillometry: an alternative modality to the conventional pulmonary function test to categorise obstructive pulmonary disorders

Cited by 58 publications

References 36 publications

Clinical application value of impulse oscillometry in geriatric patients with COPD

Clinical application value of impulse oscillometry in geriatric patients with COPD

Lung function development after preterm birth in relation to severity of Bronchopulmonary dysplasia

Evaluation of respiratory impedance in patients with chronic obstructive pulmonary disease by an impulse oscillation system

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