Impulse Oscillometry for the Diagnosis of Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Blin, E.; Pérez, Thierry; Ramon, P; Neveu, H.; Devillier, Philippe; Rivaud, Elisabeth; Chabrol, A.; Catherinot, Émilie; Tchérakian, Colas; Givel, C.; Suarez, Félipe; Nguyen, Stéphanie; Duléry, Rémy; Couderc, Louis‐Jean; Salvator, Hélène

doi:10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2990

Cited by 2 publications

(14 citation statements)

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“…Only 9/17 studies (53%) had a published manuscript available [ 42 – 44 , 46 , 48 , 53 , 55 , 57 , 58 ], with the remaining eight being described in conference abstracts. Sex distribution was available for 12/17 cohorts (71%) [ 42 – 44 , 46 – 48 , 50 , 52 , 54 , 55 , 57 , 58 ]. Age at HSCT or at time of PFT was available for all but 4/17 cohorts [ 45 , 49 , 51 , 53 ].…”

Section: Resultsmentioning

confidence: 99%

“… Age at HSCT or at time of PFT was available for all but 4/17 cohorts [ 45 , 49 , 51 , 53 ]. 12/17 studies provided number of subjects with pulmonary cGVHD [ 42 , 44 – 46 , 48 , 49 , 52 , 54 – 58 ], whilst only eight studies provided number of subjects with extrapulmonary cGVHD [ 42 , 44 , 48 , 52 , 54 , 55 , 57 , 58 ]. Among those studies reporting pulmonary cGVHD status, 4/17 (24%) did not provide the definition used [ 45 , 49 , 56 , 58 ], four used NIH criteria available at the time [ 42 , 48 , 54 , 57 ] and four used a modification of NIH criteria by adding criteria relating to presence of respiratory symptoms or cGVHD in other organ systems [ 44 , 52 , 55 ].…”

Section: Resultsmentioning

confidence: 99%

“…In one study, pulmonary cGVHD diagnosis was defined based on respiratory signs or symptoms and compatible computed tomography scan in the absence of an alternative cause [ 46 ]. Reference equations used to obtain percent predicted spirometry values, if obtained, were often not stated [ 45 , 50 , 52 , 54 , 55 , 58 – 60 ] and varied among the remaining studies. Four of 17 [ 43 , 44 , 46 , 57 ] used Global Lung Function Initiative (GLI) equations [ 61 ], one [ 42 ] used all-age reference equations, which were the precursor to GLI equations [ 62 ], and one [ 48 ] used European Coal and Steel Community equations [ 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…Sex distribution was available for 12/17 cohorts (71%) [ 42 – 44 , 46 – 48 , 50 , 52 , 54 , 55 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

“…12/17 studies provided number of subjects with pulmonary cGVHD [ 42 , 44 – 46 , 48 , 49 , 52 , 54 – 58 ], whilst only eight studies provided number of subjects with extrapulmonary cGVHD [ 42 , 44 , 48 , 52 , 54 , 55 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

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Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

et al. 2023

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Pulmonary chronic graft-versus-host disease (cGVHD) is a substantial cause of pulmonary morbidity and mortality post-haematopoietic stem cell transplantation (HSCT). Current spirometry-based monitoring strategies have significant limitations. Understanding the utility of novel peripheral airway function tests – multiple breath washout (MBW) and oscillometry – is critical in efforts to improve detection, facilitate earlier intervention and improve outcomes. In this scoping review, we identified 17 studies investigating MBW or oscillometry, or both, after allogenic HSCT. Despite small study numbers limiting the ability to draw firm conclusions, several themes were evident. Detectable peripheral airway abnormality in MBW occurred in a substantial proportion prior to HSCT. MBW indices post-HSCT were more frequently abnormal than spirometry when reporting group data and among those with extrapulmonary cGVHD and pulmonary cGVHD. Changes in MBW indices over time may be more indicative of pulmonary complications than absolute values at any given time point. Oscillometry indices were often normal at baseline, but more frequently abnormal in those who developed pulmonary cGVHD. Pooling currently available individual participant data across these studies may improve our ability to formally compare their respective sensitivity and specificity at specific time points and assess the trajectory of MBW and oscillometry indices over time.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Sex distribution was available for 12/17 cohorts (71%) [ 42 – 44 , 46 – 48 , 50 , 52 , 54 , 55 , 57 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

et al. 2023

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Obstructive and Restrictive Lung Disease After Hematopoietic Stem Cell Transplantation

Arndt

2024

MRAJ

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Pulmonary complications are frequently encountered by clinicians in patients who have undergone hematopoietic stem cell transplantation and are associated with increased morbidity and mortality in these patients. Complications involving the lung are caused by both infectious and non-infectious etiologies, with non- infectious complications associated with significant long-term effect on the quality of life and can occur several years after transplantation. One manifestation of non-infectious post-transplant complication is a change in pulmonary function testing compared to pre-transplant testing. These changes can either be of an obstructive or restrictive pattern with each being associated with specific post-transplant complications. An improved understanding of obstructive and restrictive lung disease after hematopoietic stem cell transplant is necessary for both primary care physicians and specialists to recognize these diseases early in their course in order to facilitate work-up, treatment, and necessary follow-up. This review will provide an overview of obstructive and restrictive lung disease after hematopoietic stem cell transplant focusing on the etiologies, diagnosis, treatment, and outcomes. We will highlight bronchiolitis obliterans syndrome as an example of obstructive disease after transplant and will discuss pleuroparenchymal fibroelastosis as a cause for restrictive findings on pulmonary function testing. Improvements in the knowledge of the underlying etiologies and pathophysiology of obstructive and restrictive lung disease after hematopoietic stem cell transplant will allow for the identification of novel biomarkers to facilitate the diagnosis of these patients and will assist in the design of future targeted therapies to improve treatment and prognosis.

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Impulse Oscillometry for the Diagnosis of Bronchiolitis Obliterans Syndrome After Allogeneic Hematopoietic Stem Cell Transplantation

Cited by 2 publications

References 0 publications

Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

Multiple breath washout and oscillometry after allogenic HSCT: a scoping review

Obstructive and Restrictive Lung Disease After Hematopoietic Stem Cell Transplantation

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