Impulse oscillometry in COPD: Identification of measurements related to airway obstruction, airway conductance and lung volumes

Kolsum, Umme; Borrill, Zoë; Roy, Kay; Starkey, Cerys; Vestbo, Jørgen; Houghton, Catherine M.; Singh, Dave

doi:10.1016/j.rmed.2008.07.014

Cited by 100 publications

(99 citation statements)

References 20 publications

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“…Pisi et al our results and the findings of these studies 11,12,25 showed that IOS is a reliable tool to investigate proximal and peripheral airway resistance in patients with COPD.…”

supporting

confidence: 57%

“…Notably, X5 has been reported to be a useful and informative measurement due to its close relationship with conventional pulmonary function assessments in COPD. 25 Data are presented as raw data. An upper limit of normal for R5 -R20 was chosen at 0.030 kPa⋅s⋅L …”

Section: Impulse Oscillometrymentioning

confidence: 99%

“…There are a limited number of studies that have provided IOS parameters of a population with COPD. [10][11][12][13]25 Previous studies showed that IOS parameters demonstrated good repeatability over a period of 3 months, 11 differed between subjects with COPD and smoking and nonsmoking controls, 11 could discriminate patients with different degrees of airflow limitation, 11 were significantly related with spirometry and plethysmography measures of airway patency and hyperinflation, 25 and were useful for the early detection of COPD. 12 Taken together, Abbreviations: COPD, chronic obstructive pulmonary disease; r5 -r20, fall in resistance from 5 hz to 20 hz; ΔFVC, the percentage change relative to prebronchodilator value of forced vital capacity.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease

Pisi

Aiello

Zanini

et al. 2015

5.2 Monitoring Airway Disease

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“…Pisi et al our results and the findings of these studies 11,12,25 showed that IOS is a reliable tool to investigate proximal and peripheral airway resistance in patients with COPD.…”

supporting

confidence: 57%

Section: Impulse Oscillometrymentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease

Pisi

Aiello

Zanini

et al. 2015

5.2 Monitoring Airway Disease

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“…pacity, with the strongest associations between X5 and resonant frequency and FEV 1 , and X5 and resonant frequency and sG aw . 58 A recent study in pediatric asthma has shown that only reactance area (AX) continues to improve after the initial 12 weeks of therapy with inhaled fluticasone during a 48-week total study. 59 The authors speculate that this might reflect ongoing improvement in small airway function in these patients.…”

Section: Measurement Of Airway Resistance By the Forced Oscillation Tmentioning

confidence: 99%

What Does Airway Resistance Tell Us About Lung Function?

2012

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SummarySpirometry is considered the primary method to detect the air flow limitation associated with obstructive lung disease. However, air flow limitation is the end-result of many factors that contribute to obstructive lung disease. One of these factors is increased airway resistance. Airway resistance is traditionally measured by relating air flow and driving pressure using body plethysmography, thus deriving airway resistance (R aw ), specific airway resistance (sR aw ), and specific airway conductance (sG aw ). Other methods to measure airway resistance include the forced oscillation technique (FOT), which allows calculation of respiratory system resistance (R RS ) and reactance (X RS ), and the interrupter technique, which allows calculation of interrupter resistance (R int ). An advantage of these other methods is that they may be easier to perform than spirometry, making them particularly suited to patients who cannot perform spirometry, such as young children, patients with neuromuscular disorders, or patients on mechanical ventilation. Since spirometry also requires a deep inhalation, which can alter airway resistance, these alternative methods may provide more sensitive measures of airway resistance. Furthermore, the FOT provides unique information about lung mechanics that is not available from analysis using spirometry, body plethysmography, or the interrupter technique. However, it is unclear whether any of these measures of airway resistance contribute clinically important information to the traditional measures derived from spirometry (FEV 1 , FVC, and FEV 1 /FVC). The purpose of this paper is to review the physiology and methodology of these measures of airway resistance, and then focus on their clinical utility in relation to each other and to spirometry.

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“…An increase in Rrs (extrapolated to 0 Hz) was observed from stage 1, while moderate to severe stages were distinguished more clearly by Xrs than by Rrs. In the study reported by KOLSUM et al [117], Xrs (5 Hz) and resonant frequency proved to be more closely correlated with other functional parameters than Rrs (5 Hz). An interesting point here is that the fall in FEV1 over 1 yr correlated with a fall in Xrs (5 Hz).…”

Section: Forced Oscillations and Impulse Oscillometrymentioning

confidence: 66%

Update on the roles of distal airways in COPD

Burgel

Bourdin²,

Chanez³

et al. 2011

Eur Respir Rev

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This review is the summary of a workshop on the role of distal airways in chronic obstructive pulmonary disease (COPD), which took place in 2009 in Vence, France.The evidence showing inflammation and remodelling in distal airways and the possible involvement of these in the pathobiology, physiology, clinical manifestations and natural history of COPD were examined. The usefulness and limitations of physiological tests and imaging techniques for assessing distal airways abnormalities were evaluated.Ex vivo studies in isolated lungs and invasive measurements of airway resistance in living individuals have revealed that distal airways represent the main site of airflow limitation in COPD. Structural changes in small conducting airways, including increased wall thickness and obstruction by muco-inflammatory exudates, and emphysema (resulting in premature airway closure), were important determinants of airflow limitation. Infiltration of small conducting airways by phagocytes (macrophages and neutrophils), dendritic cells and T and B lymphocytes increased with airflow limitation. Distal airways abnormalities were associated with patient-related outcomes (e.g. dyspnoea and reduced health-related quality of life) and with the natural history of the disease, as reflected by lung function decline and mortality.These data provide a clear rationale for targeting distal airways in COPD.

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Impulse oscillometry in COPD: Identification of measurements related to airway obstruction, airway conductance and lung volumes

Abstract: IOS reactance measurements are more closely related than resistance measurements to other pulmonary function measurements in COPD patients. The IOS reactance measurements appear to be indicative of changes in pulmonary compliance caused by airflow obstruction.

Cited by 100 publications

References 20 publications

Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease

Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease

What Does Airway Resistance Tell Us About Lung Function?

Update on the roles of distal airways in COPD

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