Impulsive aggression and response inhibition in attention-deficit/hyperactivity disorder and disruptive behavioral disorders: Findings from a systematic review

Puiu, Andrei A.; Wudarczyk, Olga A.; Goerlich, Katharina S.; Votinov, Mikhail; Herpertz‐Dahlmann, Beate; Turetsky, Bruce I.; Konrad, Kerstin

doi:10.1016/j.neubiorev.2018.04.016

Cited by 50 publications

(48 citation statements)

References 219 publications

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“…Diminished SN rsFC with left hemispheric clusters extending from the OFC to the frontal pole in cases compared to controls were only demonstrated when considering ADHD scores. In line with previous rs-fMRI studies (Broulidakis et al, 2016;Pu et al, 2017), cases exhibited an ADHD scores-related increase in rsFC and further corroborates the recent finding of overlapping deficit functioning in ADHD and disruptive behavior disorders (Puiu et al, 2018).…”

Section: Discussionsupporting

confidence: 91%

“…Oppositional defiant disorder (ODD) and conduct disorder (CD) are among the most common psychiatric disorders in childhood and adolescence (Polanczyk, Salum, Sugaya, Caye, & Rohde, 2015), characterized by angry and vindictive behaviors, and violating rules, norms, and rights, respectively (American Psychiatric Association, 2013). Comorbid attention-deficit/hyperactivity disorder (ADHD) symptoms are frequently present (Waschbusch, 2002) with overlapping neural deficits in prefrontal and limbic areas (Puiu et al, 2018). Recent studies of resting state fMRI (rs-fMRI) in adolescents with CD have mainly reported reduced resting state functional connectivity (rsFC) or activity.…”

Section: Introductionmentioning

confidence: 99%

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Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

Werhahn

Mohl

Willinger

et al. 2018

Preprint

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Objective: There is increasing evidence for altered resting state functional connectivity (rsFC) in adolescents with disruptive behavior. Despite considerable ongoing behavioral research suggesting also important differences relating to reactive and proactive aggression, the corresponding rsFC correlates have not been studied to date. We therefore examined associations between these aggression subtypes along with subdimensions of callous-unemotional (CU) traits and rsFC using predefined seeds in aggression-related salience network (SN) and default mode network (DMN). Method: Aggression subtypespecific whole-brain rsFC of SN and DMN seeds was investigated in a resting state sequence (mean acquisition time = 8 min 25 sec) acquired from 207 children and adolescents of both sexes aged 8 -18 years (mean age (SD) = 13.30 (2.60) years; range = 8.02 -18.35) in a multi-center study. One hundred eighteen individuals exhibited disruptive behavior (conduct disorder/oppositional defiant disorder) with different levels of comorbid ADHD symptoms, 89 were healthy. Results: Compared to healthy controls, cases demonstrated reduced DMN and -after controlling for ADHD scores -SN seed-based rsFC with left hemispheric frontal clusters. We found increased and distinct aggression-subtype specific rsFC patterns. Specifically, reactive and proactive aggression correlated with distinct SN and DMN seed-based rsFC patterns. CU dimensions led to different DMN and SN rsFC with clusters including frontal, parietal, and cingulate areas. Conclusions: This first study investigating reactive and proactive aggression along with CU dimensions reveals new subtype-specific whole-brain rsFC patterns in brain regions Werhahn et al. 4 linked to processes like emotion, empathy, moral, and cognitive control. Keywords: reactive and proactive aggression; callous-unemotional traits; default mode network; amygdala; functional connectivity.  Increasing evidence suggests mainly reduced resting state functional connectivity (rsFC) in adolescents with disruptive behavior in regions of the default mode network (DMN) and salience network (SN). While some rsFC studies evaluated the neural correlates of CU traits, reactive and proactive (RA/PA) forms of aggression have been neglected to date. We investigated DMN and SN seed-based rsFC in a large multicenter sample of children and adolescents, considering RA/PA behaviors along with CU traits. We found reduced rsFC in aggressive cases compared to controls in frontal clusters, with one pattern depending on the additional control for ADHD scores. Within cases, we found subtype-specific whole-brain rsFC patterns in brain regions previously linked to emotion, empathy, moral, and cognitive control.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

Werhahn

Mohl

Willinger

et al. 2018

Preprint

View full text Add to dashboard Cite

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“…Second, the significant decrease in the left PHG of GMV was consistent with previous neuroimaging findings in adults and children with autism (Page et al, 2009;Kosaka et al, 2010;Mueller et al, 2013;Yu et al, 2019), Moreover, severely restricted and repetitive behaviors were associated with the PHG (Monk et al, 2009;Weng et al, 2010;Hau et al, 2019). These two brain regions are implicated in unconscious relational memory encoding, autobiographical memory (Tanweer et al, 2010;Duss et al, 2014), and socioemotional behaviors (Dawson, 1991;Yang et al, 2016;Puiu et al, 2018) that are abnormal in individuals with autistic traits and in patients with clinical ASD, such as understanding the mental state of others, emotion processing, and language (Barrett et al, 2007;Lartseva et al, 2015;Grecucci et al, 2016). As previously reported, individuals with autistic traits could communicate with others in a normal way but are burdened with more social pressure (El Kaliouby et al, 2006).…”

Section: Discussionsupporting

confidence: 86%

Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits

Ren

Ward

et al. 2020

Front. Psychol.

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Individuals with autistic traits are those who present in the normal population with characteristics of social, communication, personality, and cognitive impairments but do not meet the clinical threshold for autism spectrum disorder (ASD). Most studies have focused on the abnormalities in ASD patients rather than on individuals with autistic traits. In this study, we focused on the behaviors of a large sample (N = 401) of Chinese individuals with different levels of autistic traits, measured using the Autism Spectrum Quotient, and applied voxel-based morphometry (VBM) to determine their association to differences in brain structure. The results mainly showed that the correlation between gray matter volume (GMV) and gray matter density of the brain and the Autism Spectrum Quotient was significant in these regions: the right middle frontal gyrus, which are involved in social processing and social reasoning; the left parahippocampal gyrus, which is involved in socioemotional behaviors and unconscious relational memory encoding; and the right superior parietal lobule, which are involved in cognitive control and the ability to show attention to detail. These findings reveal that people with autistic traits in the normal population have atypical development in GMV and gray matter density, which may affect their social functioning and communication ability.

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“…The life domains that are mostly impaired in individuals with ADHD are the academic, occupational, social, mental-health and self-conceptual ones, negatively impacting the lives of children and of their families (Barkley et al 2008;Matheson et al 2013;Stein, 2008). ADHD is described as a self-regulation deficit (Barkley 1997;Puiu et al 2018;Shiels and Hawk Jr 2010). Core symptoms are associated with problems in maintaining goals and plans, and an insufficient ability to inhibit impulsive responses (Sharma and Couture 2014).…”

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confidence: 99%

Clinical Effects of an ACT-Group Training in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

et al. 2019

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Objective The aim of the present study is evaluate the effectiveness of an Acceptance and Commitment Therapy (ACT)based training protocol, in adjunct to token economy and previous parent training, in a sample of children with Attention-Deficit/Hyperactivity Disorder (ADHD). By promoting the reduction of immediate responses to thoughts and feelings, we aimed to reduce the impulsive behaviour of children and to improve their self-regulation. Methods The protocol was centred on awareness of the present moment, defusion and acceptance of feelings and emotions. Behavioural (Conners' Parent Rating Scale-Revised: Long version, CPRS-R:L) and severity measures (Clinical Global Impression-Severity, CGI-S) were assessed before and after treatment in a clinical sample of 31 children aged 8-13 years. Results At the end of the ACT protocol, children showed significant improvement in global functioning and behavioural symptoms. There were significant improvements in the CPRS subscales Cognitive Problems (p = 0.005), Hyperactivity (p = 0.006), Perfectionism (p = 0.017), ADHD Index (p = 0.023), Global Index: Restless-Impulsive (p = 0.023), Global Index: Total (p = 0.036), DSM IV Inattentive (p = 0.029), DSM IV Hyperactive-Impulsive (p = 0.016), and DSM IV Total (p = 0.003). When controlling for the confounding effect of pharmacological therapy, comorbidities and socioeconomic status, treatment maintained a significant effect on the CPRS subscales Perfectionism (partial η 2 = 0.31, p < 0.01), Global Index: Restless-Impulsive (partial η 2 = 0.29, p < 0.01), Global Index: Total (partial η 2 = 0.31, p < 0.01), DSM IV Hyperactive-Impulsive (partial η 2 = 0.20, p = 0.02). Symptom severity as rated by CGI-S scores decreased in 74.2% of the children. Conclusions This preliminary work on an Acceptance and Commitment Therapy-based child training in children affected by ADHD resulted in significant improvements, measured by a rating scale specific for ADHD. Keywords ADHD • Acceptance and Commitment Therapy • Rehabilitation • Conners parent rating scale • Child training Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurobehavioral disorder common in childhood, with symptoms including troubles in paying and maintaining attention, hyperactivity and impulsive behaviour. The

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Impulsive aggression and response inhibition in attention-deficit/hyperactivity disorder and disruptive behavioral disorders: Findings from a systematic review

Cited by 50 publications

References 219 publications

Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

Aggression Subtypes Relate to Distinct Resting State Functional Connectivity in Disruptive Children and Adolescents

Atypical Brain Structures as a Function of Gray Matter Volume (GMV) and Gray Matter Density (GMD) in Young Adults Relating to Autism Spectrum Traits

Clinical Effects of an ACT-Group Training in Children and Adolescents with Attention-Deficit/Hyperactivity Disorder

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