Impulsivity and neuroendocrine response to buspirone in bulimia nervosa

Waller, David; Sheinberg, Amy L.; Gullion, Christina M.; Moeller, F. Gerard; Cannon, Dale S.; Petty, Frederick; Hardy, Bettie W.; Orsulak, Paul J.; Rush, A. John

doi:10.1016/0006-3223(95)00524-2

Cited by 15 publications

(10 citation statements)

References 25 publications

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“…Although some authors did not observe a significantly higher prevalence of such behaviours in EDs when compared to other psychiatric disorders [38] , most studies showed an increased aggressiveness against others, particularly in patients with BN [39][40][41][42][43] . Thompson et al [44] found that girls who endorsed binge eating and purging or dietary restraint had 2-to 4-fold odds of aggressive behaviour when compared to control girls; furthermore, the constellation of eating disturbances and aggressive behaviours was associated with a greater risk of drug use and attempted suicide.…”

Section: Aggressive Behaviours and Edsmentioning

confidence: 99%

Aggressiveness, Anger and Eating Disorders: A Review

Truglia¹,

Mannucci

Lassi³

et al. 2006

Psychopathology

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Anger and aggressive behaviours, especially those self-directed, are frequent in subjects suffering from anorexia nervosa and bulimia nervosa. They increase the complexity of the clinical features, change the prognosis and cause a more difficult management of these disorders. In order to elucidate the complex relationships between eating disorders, anger and aggressiveness, the history of traumatic experiences, the prevalence of dissociative, obsessive, impulsive and compulsive symptoms, as well as the role of severe personality disorders in subjects suffering from anorexia nervosa, bulimia nervosa and self-injurious behaviours are considered. In the final section of this paper, a model exploring such a relationship in the light of the undefined sense of self is described.

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Section: Aggressive Behaviours and Edsmentioning

confidence: 99%

Aggressiveness, Anger and Eating Disorders: A Review

Truglia¹,

Mannucci

Lassi³

et al. 2006

Psychopathology

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“…As concerns the deficits of impulse control in BN, an increased degree of aggressiveness has been reported in bulimic patients [4,5], but its neurobiological correlates have been poorly investigated. In general, psychobiological studies on aggression have focused mainly on serotonin (5-HT) and testosterone as major biological determinants.…”

Section: Introductionmentioning

confidence: 99%

“…To the best of our knowledge, while the potential relationships between aggressiveness and 5-HT transmission have been investigated in patients with BN [4,5], no study has been done to assess the role of endogenous gonadal steroids in the modulation of aggression in bulimic patients. Therefore, the aim of the present study was to investigate self-reported aggressive behavior in both patients with BN and healthy controls and to relate such trait measure with resting levels of estrogens, testosterone and other hormones.…”

Section: Introductionmentioning

confidence: 99%

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Cotrufo¹,

Monteleone²,

d’Istria³

et al. 2000

Neuropsychobiology

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Increased aggressiveness frequently occurs in patients with bulimia nervosa (BN), but its neurobiological correlates have been poorly investigated. In this study, we investigated possible relationships between such clinical measure and blood levels of endogenous hormones in patients with BN. Morning plasma levels of testosterone, 17β-estradiol, prolactin (PRL) and cortisol were measured in 33 bulimic women and 22 healthy female controls. The eating-related psychopathology, depression and aggressiveness were rated by specific psychometric scales. Bulimic patients showed decreased plasma levels of PRL and 17β-estradiol, and increased concentrations of cortisol and testosterone. Moreover, patients scored higher than healthy controls on rating scales assessing eating-related psychopathology, depressive symptoms and aggressiveness. A significant positive correlation was found between testosterone plasma levels and aggressiveness in patients but not in controls. These findings suggest that in BN, increased plasma levels of testosterone may play a role in the modulation of aggressiveness.

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“…Waller et al (1996) reported that in women with BN, self-reported hostility was inversely associated with the size of neuroendocrine responses following buspirone (presumed to be a 5-HT1A agonist). In bulimic women, our group has found reduced paroxetine binding and prolactin response following administration of the postsynaptic 5-HT agonist, meta-chlorophenylpiperazine (mCCP) to be associated with self-reported impulsivity (Steiger et al 2001a) and self-destructiveness (Steiger et al 2001b).…”

Section: Neurobiological Indicesmentioning

confidence: 99%

Neural Circuits, Neurotransmitters, and Behavior

Steiger

Bruce

Groleau

2010

Behavioral Neurobiology of Eating Disorders

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In bulimia nervosa (BN), and in related binge-purge syndromes, factors affecting central serotonin (5-hydroxytryptamine, 5-HT) function appear to contribute not only to appetitive dysregulation but also to temperamental and personality manifestations. Drawing upon findings from neurobiological, molecular-genetic, and brain-imaging studies, we present an integrative model of the role of 5-HT function in bulimic syndromes. At the core of our model is a consideration of the ways in which diverse hereditary and environmental influences impact the action of the 5-HT system. We believe that our model helps account for heterogeneous traits seen in the bulimic population, for disproportionate representation of individuals displaying pathological personality traits and exposure to severe environmental stressors, and for interindividual variations as to treatment response.

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Impulsivity and neuroendocrine response to buspirone in bulimia nervosa

Cited by 15 publications

References 25 publications

Aggressiveness, Anger and Eating Disorders: A Review

Aggressiveness, Anger and Eating Disorders: A Review

Aggressive Behavioral Characteristics and Endogenous Hormones in Women with Bulimia nervosa

Neural Circuits, Neurotransmitters, and Behavior

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