Impulsivity differences in recreational cannabis users and binge drinkers in a university population

Moreno, Margarita; Estévez, Ángeles F.; Basurto, Flor Zaldívar; Montes, José Manuel García; Gutiérrez-Ferre, Valeria E.; Esteban, Laura; Sánchez-Santed, Fernando; Flores, Pilar

doi:10.1016/j.drugalcdep.2012.02.011

Cited by 123 publications

(109 citation statements)

References 80 publications

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“…There is considerable evidence implicating the use of various cannabis derivatives in altered cognition and decision making, including risk taking behavior, irrational (or excessive) gambling, as well as impulsive and apathetic patterns of choice. This evidence comes mainly from human studies (Dougherty et al 2013;Grant et al 2012;Hermann et al 2009;Lane et al 2005;Moreno et al 2012;Solowij et al 2012;Whitlow et al 2004) and related work in animals (Boomhower et al 2013;Egerton et al 2006;Egerton et al 2005;Mishima et al 2002) that largely concurs with the results of the human studies. The role of cannabinoid signaling in decision-making pathways and the involvement of cannabinoid receptors in frontal cortical circuits of decision making have not received much attention to date.…”

Section: Introductionsupporting

confidence: 66%

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

et al. 2014

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Despite the evidence for altered decision making in cannabis abusers, the role of the cannabinoid system in decision-making circuits has not been studied. Here, we examined the effects of cannabinoid modulation during costbenefit decision making in the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), key brain areas involved in decision making. We trained different groups of rats in a delay-based and an effort-based form of cost-benefit T-maze decision-making task. During test days, the rats received local injections of either vehicle or ACEA, a cannabinoid type-1 receptor (CB1R) agonist in the ACC or OFC. We measured spontaneous locomotor activity following the same treatments and characterized CB1Rs localization on different neuronal populations within these regions using immunohistochemistry. We showed that CB1R activation in the ACC impaired decision making such that rats were less willing to invest physical effort to gain high reward. Similarly, CB1R activation in the OFC induced impulsive pattern of choice such that rats preferred small immediate rewards to large delayed rewards. Control tasks ensured that the effects were specific for differential cost-benefit tasks. Furthermore, we characterized widespread colocalizations of CB1Rs on GABAergic axonal ends but few colocalizations on glutamatergic, dopaminergic, and serotonergic neuronal ends. These results provide first direct evidence that the cannabinoid system plays a critical role in regulating cost-benefit decision making in the ACC and OFC and implicate cannabinoid modulation of synaptic ends of predominantly interneurons and to a lesser degree other neuronal populations in these two frontal regions.

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Section: Introductionsupporting

confidence: 66%

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

et al. 2014

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“…Evidence for effects of chronic cannabis use on decision-making is mixed. Although several studies reported poorer decision-making performance across a range of tasks (48,78,82,117,123,124), especially decreased sensitivity to loss and greater sensitivity to gains (123), clear group differences were not found in other studies (45,50,94,(125)(126)(127). Cognitive flexibility in decision making is also affected by chronic cannabis exposure (45,113,116).…”

Section: Decision Making Reward Processing and Delay Discountingmentioning

confidence: 97%

Acute and Chronic Effects of Cannabinoids on Human Cognition—A Systematic Review

Broyd

Hell

Beale

et al. 2016

Biological Psychiatry

547

395

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Cannabis use has been associated with impaired cognition during acute intoxication as well as in the unintoxicated state in long-term users. However, the evidence has been mixed and contested, and no systematic reviews of the literature on neuropsychological task-based measures of cognition have been conducted in an attempt to synthesize the findings. We systematically review the empirical research published in the past decade (from January 2004 to February 2015) on acute and chronic effects of cannabis and cannabinoids and on persistence or recovery after abstinence. We summarize the findings into the major categories of the cognitive domains investigated, considering sample characteristics and associations with various cannabis use parameters. Verbal learning and memory and attention are most consistently impaired by acute and chronic exposure to cannabis. Psychomotor function is most affected during acute intoxication, with some evidence for persistence in chronic users and after cessation of use. Impaired verbal memory, attention, and some executive functions may persist after prolonged abstinence, but persistence or recovery across all cognitive domains remains underresearched. Associations between poorer performance and a range of cannabis use parameters, including a younger age of onset, are frequently reported. Little further evidence has emerged for the development of tolerance to the acutely impairing effects of cannabis. Evidence for potential protection from harmful effects by cannabidiol continues to increase but is not definitive. In light of increasing trends toward legalization of cannabis, the knowledge gained from this body of research needs to be incorporated into strategies to minimize harm. Review Acute and Chronic Effects of Cannabinoids on Human Cognition-A Systematic ReviewSamantha J. Broyd, Hendrika H. van Hell, Camilla Beale, Murat Yücel, and Nadia Solowij ABSTRACT Cannabis use has been associated with impaired cognition during acute intoxication as well as in the unintoxicated state in long-term users. However, the evidence has been mixed and contested, and no systematic reviews of the literature on neuropsychological task-based measures of cognition have been conducted in an attempt to synthesize the findings. We systematically review the empirical research published in the past decade (from January 2004 to February 2015) on acute and chronic effects of cannabis and cannabinoids and on persistence or recovery after abstinence. We summarize the findings into the major categories of the cognitive domains investigated, considering sample characteristics and associations with various cannabis use parameters. Verbal learning and memory and attention are most consistently impaired by acute and chronic exposure to cannabis. Psychomotor function is most affected during acute intoxication, with some evidence for persistence in chronic users and after cessation of use. Impaired verbal memory, attention, and some executive functions may persist after prolonged abstinence, but persistenc...

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“…Moreover, while it is almost impossible to estimate the unique effects of cannabis on cancer given high co-occurring rates of cannabis and tobacco use, cannabis has four times the amount of tar as cigarettes and causes similar damage to the mucous membranes in the trachea and bronchi that is associated with increased risk of lung and bronchial cancers (Dennis et al, 2002). Finally, cannabis use has also been associated with motor vehicle accidents and driving impairments, non-traffic injuries, emergency department admissions, drug-related deaths, mortality following treatment of cannabis use disorders, legal problems other than for cannabis possession or trafficking, reduced work commitment, reduced life satisfaction among individuals with cannabis use disorder symptoms, negative psychosocial parameters among patients with fibromyalgia, impulsivity among recreational/non-dependent cannabis users, and alterations of theory of mind network activation (Arendt, Munk-Jorgensen, Sher, & Jensen, 2013;Barrio et al, 2012;Bosker et al, 2012;Dennis et al, 2002;Downey et al, 2013;Hyggen, 2012;Moreno et al, 2012;Roser et al, 2012;Ste-Marie, Fitzcharles, Gamsa, Ware, & Shir, 2012;Swain, Gibb, Horwood, & Fergusson, 2012).…”

Section: Benefits and Harms Of Cannabis Usementioning

confidence: 99%

Recovery from cannabis use disorders: Abstinence versus moderation and treatment-assisted recovery versus natural recovery.

Stea

Yakovenko

Hodgins

2015

Psychology of Addictive Behaviors

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The recovery process from cannabis use disorders has received little empirical attention. Understanding how and the ways in which individuals with cannabis use disorders recover may help to improve formal treatments and facilitate recovery for those who wish to not seek treatment. The present study was undertaken with two primary objectives in mind. The first primary objective was to provide an exploratory portrait of the recovery process from cannabis use disorders from the perspective of individuals who have recovered. The second primary objective was to explore and systematically describe the similarities and differences between abstinence-and moderation-oriented recoveries, as well as the similarities and differences between treatment-assisted and natural recoveries. The methodology was largely borrowed from the natural recovery literature insofar as recovery was first inferred via the remission of diagnostic symptoms, and then explored predominantly via several interview domains (e.g., reasons for resolution, actions taken to recover, maintenance factors, barriers to treatment seeking).Several interesting and important findings emerged at the level of the total sample (N = 119), as well as at the level of group comparisons between the different recovery pathways. Notably, the findings lend further support to the effectiveness of cognitive, motivational, and behavioural strategies as helpful actions and maintenance factors

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Impulsivity differences in recreational cannabis users and binge drinkers in a university population

Cited by 123 publications

References 80 publications

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

Activation of cannabinoid system in anterior cingulate cortex and orbitofrontal cortex modulates cost-benefit decision making

Acute and Chronic Effects of Cannabinoids on Human Cognition—A Systematic Review

Recovery from cannabis use disorders: Abstinence versus moderation and treatment-assisted recovery versus natural recovery.

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