Impulsivity is associated with behavioral decision-making deficits

Franken, Ingmar H.A.; Strien, Jan W. Van; Nijs, Ilse M.T.; Muris, Peter

doi:10.1016/j.psychres.2007.06.002

Cited by 241 publications

(197 citation statements)

References 56 publications

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“…Increased disadvantageous risk taking in the Iowa Gambling Task has been regularly associated to enhanced impulsivity, especially in terms of UPPS-P Lack of Premeditation (Zermatten et al, 2005;Franken et al, 2008) and the BIS-11 Nonplanning and Motor Impulsiveness scales (Snowden and Gray, 2011). However, according to Sharma et al, (2013) the inter-correlations between behaviourally assessed motor impulsivity and self-reported impulsivity levels are relatively low.…”

Section: Discussionmentioning

confidence: 99%

Response inhibition in the parametric Go/No-Go task in psychopathic offenders

Weidacker

Snowden

Boy

et al. 2017

Psychiatry Research

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Previous research on response inhibition in psychopaths has failed to find consistent evidence for aberrant inhibitory ability, despite strong expectations to the contrary. However, previous examinations have utilised inhibition paradigms that suffer from critical shortcomings, such as a lack of ecological validity and overly simplistic response criteria. To assess inhibition under conditions close to the demands of everyday settings, the current study employs a parametric Go/No-go task in male offenders (n = 77). Additionally, rather than treating psychopathy as a categorical descriptor, a dimensional approach is taken to assess the relationship between individual psychopathic traits and response inhibition performance.Results indicate significant relationships between response inhibition and individual facets of psychopathy as measured by the Psychopathy Checklist: Screening Version. A positive relationship was found between inhibitory ability and interpersonal aspects of psychopathy, reflecting an enhancement of inhibitory functioning for those scoring high on this facet. In addition, a negative association was found between psychopathic lifestyle characteristics and response inhibition. Whereas the negative association mirrors the conceptualisation of the lifestyle facet, the positive association between interpersonal psychopathic aspects and response inhibition might reflect a propensity for adaptive behaviour that enables psychopaths to adequately manipulate their victims and mask their true nature.

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Section: Discussionmentioning

confidence: 99%

Response inhibition in the parametric Go/No-Go task in psychopathic offenders

Weidacker

Snowden

Boy

et al. 2017

Psychiatry Research

View full text Add to dashboard Cite

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“…However, recent reports showed the complexity of this task that might also be considered as a measure of risk taking [1,[8][9][10][11]. In particular, poor performance during the first part of the task has been related to ambiguous risk taking [12][13][14][15].…”

Section: Cognitive Impulsivitymentioning

confidence: 99%

Impulsivity and Parkinson's disease: More than just disinhibition

Antonelli

Ray

Strafella

2011

Journal of the Neurological Sciences

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In the last few years it has become clear that impulsivity is a complex behaviour composed of different domains and dependent on different neural networks. The proposed pathogenetic mechanisms for the emergence of impulsivity disorders in Parkinson's Disease (PD) can be broadly separated into three potentially interacting processes: the contribution of premorbid susceptibility to impulsivity, the contribution of the disease itself to the behaviour and the potential contribution of therapeutic agents. Growing evidence suggests that dopamine and the subthalamic nucleus are playing a certain role in the pathophysiology of different aspects of impulsivity. In this review, we summarise the main concepts defining various components of impulsivity both in healthy subjects and patients affected by PD.

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“…Patients with damage to the amygdala or ventromedial prefrontal cortex (VMPFC), which encompasses the OFC, are impaired on the IGT-choosing more cards from decks associated with larger rewards, yet disproportionately greater long-term losses (Bechara et al, 1999). Based on these original reports, IGT impairments in psychiatric populations are often interpreted as a direct indication of OFC dysfunction without any further proof aside from the behavioral impairment (Franken et al, 2008;Starcke et al, 2010). However, the role of the OFC in regulating this type of decision making has recently been challenged (Fellows and Farah, 2005;Fellows, 2007).…”

Section: Introductionmentioning

confidence: 99%

Lesions of the Basolateral Amygdala and Orbitofrontal Cortex Differentially Affect Acquisition and Performance of a Rodent Gambling Task

Zeeb¹,

Winstanley²

2011

J. Neurosci.

138

115

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Risky decision making on the Iowa Gambling Task (IGT) has been observed in several psychiatric disorders, including substance abuse, schizophrenia, and pathological gambling. Such deficits are often attributed to impaired processing within the orbitofrontal cortex (OFC) because patients with damage to this area or to the amygdala, which is strongly interconnected with the OFC, can likewise show enhanced choice of high-risk options. However, whether damage to the OFC or amygdala impairs subjects' ability to learn the task, or actually affects the decision-making process itself, is currently unclear. To address these issues, rats were trained to perform a rodent gambling task (rGT) either before or after bilateral excitotoxic lesions to the basolateral amygdala (BLA) or OFC. Maximum profits in both the rGT and IGT are obtained by favoring smaller rewards associated with lower penalties, and avoiding the tempting, yet ultimately disadvantageous, large reward options. Lesions of the OFC or BLA made before task acquisition initially impaired animals' ability to determine the optimal strategy, but did not disrupt decision making in the long term. In contrast, lesions of the BLA, but not the OFC, made after the task had been acquired increased risky choice. These results suggest that, although both regions contribute to the development of appropriate choice behavior under risk, the BLA maintains a more fundamental role in guiding these decisions. The maladaptive choice pattern observed on the IGT in patients with OFC lesions could therefore partially reflect a learning deficit, whereas amygdala damage may give rise to a more robust decision-making impairment.

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Impulsivity is associated with behavioral decision-making deficits

Cited by 241 publications

References 56 publications

Response inhibition in the parametric Go/No-Go task in psychopathic offenders

Response inhibition in the parametric Go/No-Go task in psychopathic offenders

Impulsivity and Parkinson's disease: More than just disinhibition

Lesions of the Basolateral Amygdala and Orbitofrontal Cortex Differentially Affect Acquisition and Performance of a Rodent Gambling Task

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