Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson’s Disease

Tahmasian, Masoud; Rochhausen, Luisa; Maier, Franziska; Williamson, Kim L.; Drzezga, Alexander; Timmermann, Lars; Eimeren, Thilo van; Eggers, Carsten

doi:10.3389/fnbeh.2015.00317

Cited by 19 publications

(15 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies have shown that metabolic patterns associated with impulsivity and hypomania in PD are mostly found within the fronto-insular network. [79][80][81] This is in line with the view that the insula plays an important role in various nonmotor disturbances in PD. 82 Metabolic activity has also demonstrated spatially distributed networks of brain function.…”

Section: Blood Flow and Metabolismsupporting

confidence: 88%

“…As mentioned earlier, increased impulsivity and hypomania are nonmotor symptoms associated with behavioral addictions (e.g., pathological gambling) that may occur with dopamine replacement therapy. Recent studies have shown that metabolic patterns associated with impulsivity and hypomania in PD are mostly found within the fronto‐insular network . This is in line with the view that the insula plays an important role in various nonmotor disturbances in PD …”

Section: Molecular Imaging Of Pdsupporting

confidence: 82%

See 1 more Smart Citation

Imaging Markers of Progression in Parkinson's Disease

Strafella

Bohnen

Pavese

et al. 2018

Movement Disord Clin Pract

View full text Add to dashboard Cite

Background Parkinson's disease (PD) is the second‐most common neurodegenerative disorder after Alzheimer's disease; however, to date, there is no approved treatment that stops or slows down disease progression. Over the past decades, neuroimaging studies, including molecular imaging and MRI are trying to provide insights into the mechanisms underlying PD. Methods This work utilized a literature review. Results It is now becoming clear that these imaging modalities can provide biomarkers that can objectively detect brain changes related to PD and monitor these changes as the disease progresses, and these biomarkers are required to establish a breakthrough in neuroprotective or disease‐modifying therapeutics. Conclusions Here, we provide a review of recent observations deriving from PET, single‐positron emission tomography, and MRI studies exploring PD and other parkinsonian disorders.

show abstract

Section: Blood Flow and Metabolismsupporting

confidence: 88%

Section: Molecular Imaging Of Pdsupporting

confidence: 82%

Imaging Markers of Progression in Parkinson's Disease

Strafella

Bohnen

Pavese

et al. 2018

Movement Disord Clin Pract

View full text Add to dashboard Cite

show abstract

“…In addition, in PD, Cilia et al () reported also an increased SPECT perfusion of orbito‐frontal region in patients with ICDs. Tahmasian et al () suggest that the hyperactivity of the orbitofrontal cortex is essential for adapted inhibition of behaviors in PD patients with high impulsivity. Nevertheless, it remains impossible to formally determining whether the frontal regions have a role in inhibiting behavior among ICD patients or rather causally involved in the genesis of ICDs.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in PD, Cilia et al (2008) reported also an increased SPECT perfusion of orbitofrontal region in patients with ICDs. Tahmasian et al (2015) suggest that the hyperactivity of the orbitofrontal cortex is essential for adapted inhibition of behaviors in PD patients with high impulsivity.…”

Section: Discussionmentioning

confidence: 99%

Brain PET substrate of impulse control disorders in Parkinson's disease: A metabolic connectivity study

Verger

Klesse

Chawki

et al. 2018

Human Brain Mapping

View full text Add to dashboard Cite

Impulse control disorders (ICDs) have received increased attention in Parkinson's disease (PD) because of potentially dramatic consequences. Their physiopathology, however, remains incompletely understood. An overstimulation of the mesocorticolimbic system has been reported, while a larger network has recently been suggested. The aim of this study is to specifically describe the metabolic PET substrate and related connectivity changes in PD patients with ICDs. Eighteen PD patients with ICDs and 18 PD patients without ICDs were evaluated using cerebral 18F-fluorodeoxyglucose positron emission tomography. SPM-T maps comparisons were performed between groups and metabolic connectivity was evaluated by interregional correlation analysis (IRCA; p < .005, uncorrected; k > 130) and by graph theory (p < .05). PD patients with ICDs had relative increased metabolism in the right middle and inferior temporal gyri compared to those without ICDs. The connectivity of this area was increased mostly with the mesocorticolimbic system, positively with the orbitofrontal region, and negatively with both the right parahippocampus and the left caudate (IRCA). Moreover, the betweenness centrality of this area with the mesocorticolimbic system was lost in patients with ICDs (graph analysis). ICDs are associated in PD with the dysfunction of a network exceeding the mesocorticolimbic system, and especially the caudate, the parahippocampus, and the orbitofrontal cortex, remotely including the right middle and inferior temporal gyri. This latest area loses its central place with the mesocorticolimbic system through a connectivity dysregulation.

show abstract

“…Larger gray matter volumes in MPFC and DLPFC, as well as subcortical regions, correlated positively with the Barratt Impulsiveness Scale 11 (24) in healthy adults (62); for negative urgency (as measured by the UPPS-P), greater impulsivity correlated positively with lateral PFC gray matter volumes in cocaine users (63) and negatively with DMPFC gray matter volumes in healthy participants (64). Glucose metabolism (a proxy measure of neural activity) in the fronto-insular network, including the right insula, ACC and orbitofrontal cortex, correlated positively with impulsivity as measured by the BIS-11 in patients with Parkinson’s Disease (65). Similarly, fMRI studies have found that the BIS-11 correlated positively with DLPFC activation in 3,4-methylenedioxymethamphetamine (MDMA, ‘ecstasy’) users and controls during a delayed memory task (66) and with activation in the ACC (67) and middle frontal gyrus (68) elicited by a Go/No-Go task with healthy participants, despite observing no differences in task performance.…”

Section: Discussionmentioning

confidence: 99%

Prefrontal Cortical Activity During the Stroop Task: New Insights into the Why and the Who of Real-World Risky Sexual Behavior

Barkley-Levenson

Xue

Droutman

et al. 2018

Annals of Behavioral Medicine

View full text Add to dashboard Cite

Background Research suggests that deficits in both executive functioning and trait impulsivity may play a role in risky sexual behavior. At the neural level, differences in regulation of the prefrontal cortex have been linked to impulsivity, measured neurocognitively and through self-report. The relationship between neurocognitive measures of executive control and trait impulsivity in predicting risky sexual behavior has not been investigated. Purpose To investigate the relationship between neural functioning during the Stroop task and risky sexual behavior, as well as the effect of individual differences in urgent (positive and negative) impulsivity on this relationship. Methods 105 sexually active men who have sex with men (MSM) completed the Stroop task during functional magnetic resonance imaging scanning. They also completed impulsivity inventories and self-reported their risky sexual behavior (events of condomless anal sex in the last 90 days). Results Risky participants had greater activation than safe participants during the color congruent condition of the Stroop task in anterior cingulate cortex/dorsomedial prefrontal cortex, dorsolateral prefrontal cortex, left frontal pole, and right insula. Across these regions, this neural activation mediated the link between (positive and/or negative) urgent impulsivity and risky sexual behavior. Conclusions Findings suggest that the brains of men who engage in risky sexual behavior may employ a different distribution of cognitive resources during tasks of executive functioning than men who practice safe sex, and that this may relate to differences in the prefrontal cortical/fronto-insular system responsible for impulse control.

show abstract

Impulsivity is Associated with Increased Metabolism in the Fronto-Insular Network in Parkinson’s Disease

Cited by 19 publications

References 81 publications

Imaging Markers of Progression in Parkinson's Disease

Imaging Markers of Progression in Parkinson's Disease

Brain PET substrate of impulse control disorders in Parkinson's disease: A metabolic connectivity study

Prefrontal Cortical Activity During the Stroop Task: New Insights into the Why and the Who of Real-World Risky Sexual Behavior

Contact Info

Product

Resources

About