Impurity profile study of zaleplon

Bharathi, Ch.; Prabahar, Koilpillai Joseph; Prasad, Ch.S.; Kumar, M. Saravana; Magesh, S.; Handa, V. K.; Dandala, Ramesh; Naidu, A.

doi:10.1016/j.jpba.2007.01.051

Cited by 20 publications

(10 citation statements)

References 5 publications

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“…Probucol ( 5 ) is an antihyperlipidemic drug initially developed for the treatment of coronary artery disease. Quetiapine8d ( 6 ) (branded as Seroquel, Xeroquel, and Ketipinor) is being used for the treatment of schizophrenia and bipolar disorder, and is also prescribed as an antidepressant to treat major depressive disorder.…”

Section: Introductionmentioning

confidence: 99%

Transition‐Metal‐Catalyzed CS Bond Coupling Reaction

Lee

Liu

Badsara

2014

Chemistry An Asian Journal

437

122

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Sulfur-containing molecules such as thioethers are commonly found in chemical biology, organic synthesis, and materials chemistry. While many reliable methods have been developed for preparing these compounds, harsh reaction conditions are usually required in the traditional methods. The transition metals have been applied in this field, and the palladium-catalyzed coupling of thiols with aryl halides and pseudo halides is one of the most important methods in the synthesis of thioethers. Other metals have also been used for the same purpose. Here, we summarize recent efforts in metal-catalyzed C-S bond cross-coupling reactions, focusing especially on the coupling of thiols with aryl- and vinyl halides based on different metals.

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Section: Introductionmentioning

confidence: 99%

Transition‐Metal‐Catalyzed CS Bond Coupling Reaction

Lee

Liu

Badsara

2014

Chemistry An Asian Journal

437

122

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“…22,23) The inclusion of a guest molecule in the hydrophobic cavity of a CD molecule generally modifies the environment of the protons of the guest moiety and the host cavity. Therefore, [23][24][25] The NMR peaks of quetiapine in the presence of βCD were assigned by 1 H, 13 C, and twodimensional NMR measurements. In Fig.…”

Section: Resultsmentioning

confidence: 99%

Quetiapine Free Base Complexed with Cyclodextrins to Improve Solubility for Parenteral Use

et al. 2013

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Quetiapine, an antipsychotic drug used for schizophrenia treatment, is poorly water soluble, and therefore, administration of the more water-soluble quetiapine fumarate is preferred. Absorption of quetiapine through biological membranes may be improved by enhancing the solubility of the quetiapine base, the non-ionic form. In this study, the currently used salt form was converted into the free base (oily material). We employed cyclodextrins (CDs) as pharmaceutical additives to improve the solubility of the quetiapine base. The formation of quetiapine-β-cyclodextrin (β-CD) complexes was studied by phase solubility studies, continuous variation method, NMR spectroscopy, and powder X-ray diffraction. The formation of a poorly water-soluble complex was confirmed by the phase solubility study, and the interaction between quetiapine and β-CD in water was confirmed by NMR spectroscopy. In addition, the effects of β-CD derivatives (glucosyl-β-CD, maltosyl-β-CD, 2-hydroxypropyl-β-CD, dimethyl-β-CD, and trimethyl-β-CD) on the solubility of the quetiapine base were studied. The findings indicated that the aforementioned hydrophilic β-CD derivatives could be used as pharmaceutical additives of quetiapine for parenteral formulations as a result of the improved solubility of the quetiapine base because of inclusion complexation. Therefore, converting the currently used salt form into the free base, investigating the free base as a candidate for CD inclusion, and converting the oily material such as the free base into a powder by forming an inclusion complex that is easy to deal with is considered a worthwhile approach that may lead to novel formulations of the drug in question.

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“…The reported chromatogra-phic techniques [4][5][6][7][8][9][10][11]21,22,[30][31][32][33][34][35][36] have several disadvantages such as expensive instrumental setup, multiple steps, longer analysis time, stringent experimental conditions to be maintained, and several clean-up steps. The reported chromatogra-phic techniques [4][5][6][7][8][9][10][11]21,22,[30][31][32][33][34][35][36] have several disadvantages such as expensive instrumental setup, multiple steps, longer analysis time, stringent experimental conditions to be maintained, and several clean-up steps.…”

Section: Resultsmentioning

confidence: 99%

Extractive spectrophotometric determination of Quetiapine fumarate in pharmaceuticals and human urine using calmagite as an ion-pair reagent

Rajendraprasad

Basavaiah

Vinay

2011

CI&CEQ

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Quetiapine fumarate (QTF) is an antipsychotic drug belonging to the benzisoxazole derivatives indicated for the treatment of schizophrenia. A sensitive and selective method based on dichloromethane-extractable ion-pair of QTF with calmagite (CGT), which exhibited an absorption maximum at 490 nm, is described. At this wavelength, Beer's law is obeyed over the concentration range of 3.0-30.0 µg ml -1 . The apparent molar absorptivity, limit of detection (LOD) and quantitation (LOQ) values are 1.32×10 4 l mol -1 cm -1 , 0.27 and 0.81 µg ml -1 , respectively. The reaction is extremely rapid at room temperature and the absorbance values remain unchanged up to 19 h. The precision results, expressed as intra-day and inter-day relative standard deviation values, are satisfactory (RSD ≤ 2.2%). The accuracy is satisfactory as well (RE ≤ 2.44%). The method was successfully applied to the determination of QTF in pharmaceuticals and spiked human urine with satisfactory results. No interference was observed from common pharmaceutical adjuvants in tablets. Statistical comparison of the results with the official method showed an excellent agreement and indicated no significant difference in precision.

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Impurity profile study of zaleplon

Cited by 20 publications

References 5 publications

Transition‐Metal‐Catalyzed CS Bond Coupling Reaction

Transition‐Metal‐Catalyzed CS Bond Coupling Reaction

Quetiapine Free Base Complexed with Cyclodextrins to Improve Solubility for Parenteral Use

Extractive spectrophotometric determination of Quetiapine fumarate in pharmaceuticals and human urine using calmagite as an ion-pair reagent

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