Imunopatogênese da psoríase

Sanchez, Ana Paula Galli

doi:10.1590/s0365-05962010000500028

Cited by 23 publications

(36 citation statements)

References 9 publications

(38 reference statements)

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“…Psoriasis is a common, chronic immune-mediated inflammatory skin disorder [1][2][3][4][5]. In genetically predisposed individuals, environmental factors cause an exaggerated activation of the Innate Immune System (IIS) and the Adaptive Immune System (AIS), leading to excessive proliferation of keratinocytes and the appearance of skin lesions [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…Initially there is a hyperactivation of IIS cells, especially keratinocytes, dermal Dendritic Cells (DC) and macrophages [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…In psoriasis there is enhanced expression of "Toll Like Receptors" (TLR) on the keratinocytes and on the DC (TLR is a type of PRR) [2,3]. It occurs also excessive production of HSP and AMP by keratinocytes [1][2][3]. Moreover, there is increased expression of several genes that participate in innate immune (and adaptive) responses [2,[4][5][6].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, there is increased expression of several genes that participate in innate immune (and adaptive) responses [2,[4][5][6]. Activated keratinocytes, DC and macrophages produce various proinflammatory cytokines such as interleukin (IL) 1, IL-6, tumoral alpha necrosis factor (TNF-α) and interferon (INF) [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…INF-α and other proinflammatory cytokines (produced mainly by activated macrophages and keratinocytes) promote an excessive activation of the myeloid dermal dendritic cells (mDC), whose number is much increased in psoriatic plaques ( Figure 1) [1][2][3][4][5]. [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

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Better Understanding the Immunopathogenesis of Psoriasis

Sanchez¹

2017

CRDOA

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The immunopathogenesis of psoriasis involves complex interactions between the innate and the adaptive immune system, with emphasis on participation of keratinocytes, neutrophils, dermal dendritic cells and T lymphocytes.The knowledge of the immunopathogenesis of the disease is essential for understanding the mechanism of action of several systemic medications used in the treatment of the disease, especially the biologics.In this article the main and current knowledge of the immunopathogenesis of psoriasis is summarised. 2

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Section: Introductionmentioning

confidence: 99%

“…Initially there is a hyperactivation of IIS cells, especially keratinocytes, dermal Dendritic Cells (DC) and macrophages [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Better Understanding the Immunopathogenesis of Psoriasis

Sanchez¹

2017

CRDOA

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Pathogen DNA also contributes to interferon regulatory factor 3 activation in hepatic cells: Implications for alcoholic liver diseases

et al. 2011

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We read with interest the reviews by Ghouri et al. 1 and Martinez et al. 2 Ghouri et al. analyzed the association of nonalcoholic fatty liver disease (NAFLD) with cardiovascular disease (CVD) and concluded that although a diagnosis of NAFLD should prompt diabetes screening, it is insufficient for considering patients to be at high risk for CVD. Martinez et al. evaluated noninvasive methods for assessing liver fibrosis and recommended that those tests with the highest diagnostic accuracy be validated against liver biopsy to facilitate their implementation in clinical practice.We meta-analyzed prospective data regarding the natural history of NAFLD and studies assessing the diagnostic accuracy of noninvasive methods for liver disease severity against liver biopsy in NAFLD, and we reached the following conclusions 3 :1. The two NAFLD histological subtypes, simple steatosis (SS) and nonalcoholic steatohepatitis (NASH), have different risks of liver-related complications: SS progresses to cirrhosis in less than 5% of cases; NASH progresses to cirrhosis in 10% to 15% of cases over 10 years and in 25% to 30% of cases in the presence of advanced fibrosis. 3 2. NAFLD patients have a 1.44-to 2.05-fold higher rate of CVD (depending on whether the diagnosis is based on an aminotransferase elevation or radiological/histological criteria) than the general population; restricting the analysis to studies adjusting for metabolic syndrome did not change the risk. Importantly, CVD mortality did not differ among NAFLD histological subtypes. 3 3. NAFLD conveys a 2-fold increased risk of developing diabetes in comparison with the general population 3 ; restricting the analysis to studies adjusting for metabolic syndrome did not change the risk. Whether the risk of diabetes differs among NAFLD histological subtypes remains unclear: in a communitybased study, the 13-year incidence of diabetes was 2.98-fold higher in NASH patients versus SS patients. 3 According to our analysis, a diagnosis of NAFLD should prompt a thorough three-focus assessment of cardiovascular, metabolic, and liver-related risks (Table 1). 4 Liver-related risk assessment remains problematic because it requires liver histology. Three noninvasive methods have been extensively validated: enzyme-linked immunosorbent assay-detected cytokeratin 18 fragments (9 studies enrolling 856 participants) for the detection of NASH and the NAFLD fibrosis score (13 studies enrolling 3064 participants) and FibroScan (6 studies enrolling 563 participants) for the detection of advanced fibrosis. We believe that these methods should be promptly implemented in diagnostic algorithms to select patients for liver biopsy in routine clinical practice while we continue to search for the ideal noninvasive marker.

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Reactivation of human polyomavirus JC in patients affected by psoriasis vulgaris and psoriatic arthritis and treated with biological drugs: Preliminary results

Nardis

Anzivino

Bellizzi

et al. 2012

Journal Cellular Physiology

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Psoriasis vulgaris (PsV) and psoriatic arthritis (PSA) are inter‐related heritable inflammatory skin diseases. Psoriatic lesions develop as a result of abnormal immune responses, hyperproliferation and altered differentiation of keratinocytes, and a notable subset of psoriatic patients develops PsA, characterized by joints inflammation. Recently, biological drugs were introduced to treat these diseases. However, this therapy has already been associated with the development of serious life‐threatening infections, such as the reactivation of human polyomavirus JC (JCV), responsible for the progressive multifocal leukoencephalopathy (PML), a lethal demyelinating disease caused by oligodendrocytes lytic infection. Therefore, the aims of our study were the investigation of the possible JCV reactivation in PsV and PsA patients treated with adalimumab, etanercept, and methotrexate, performing quantitative real‐time PCR in sera and skin biopsies at the time of recruitment (T0) and after 3 (T3) and 6 (T6) months of treatment, and the sequencing analysis of the JCV non‐coding control region (NCCR). We found JCV DNA in 5/15 PsV patients and in 2/15 PsA patients and JCV NCCR sequence analysis always showed a structure similar to non‐pathogenic CY archetype, with random occurrence of a few irrelevant point mutations. Nevertheless the poor number of patients analyzed, our preliminary data can pave the way for taking into account that the follow‐up of JCV DNA detection and the JCV NCCR sequence analysis in psoriatic patients may be important to evaluate the risk of PML onset, considering that patients affected by autoimmune diseases and treated with biologics continue to rise. J. Cell. Physiol. 227: 3796–3802, 2012. © 2012 Wiley Periodicals, Inc.

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Imunopatogênese da psoríase

Cited by 23 publications

References 9 publications

Better Understanding the Immunopathogenesis of Psoriasis

Better Understanding the Immunopathogenesis of Psoriasis

Pathogen DNA also contributes to interferon regulatory factor 3 activation in hepatic cells: Implications for alcoholic liver diseases

Reactivation of human polyomavirus JC in patients affected by psoriasis vulgaris and psoriatic arthritis and treated with biological drugs: Preliminary results

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