In and ex utero maturation of premature infants electroencephalographic indices

Shany, Eilon; Meledin, Irina; Gilat, Shlomo; Yogev, Hagai; Golan, Agneta; Berger, Itai

doi:10.1016/j.clinph.2013.06.185

Cited by 23 publications

(21 citation statements)

References 18 publications

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“…kangaroo care, light and sound stimulus, prone position, length of recording), which can all influence the quality of sleep expression, and the time variation of the SWC [19,54,56–59]. …”

Section: Qualitative Assessment Of Neonatal Sleepmentioning

confidence: 99%

Review of sleep-EEG in preterm and term neonates

Dereymaeker

Pillay

Vervisch

et al. 2017

Early Human Development

109

117

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Neonatal sleep is a crucial state that involves endogenous driven brain activity, important for neuronal survival and guidance of brain networks. Sequential EEG-sleep analysis in preterm infants provides insights into functional brain integrity and can document deviations of the biologically pre-programmed process of sleep ontogenesis during the neonatal period. Visual assessment of neonatal sleep-EEG, with integration of both cerebral and non-cerebral measures to better define neonatal state, is still considered the gold standard. Electrographic patterns evolve over time and are gradually time locked with behavioural characteristics which allow classification of quiet sleep and active sleep periods during the last 10weeks of gestation. Near term age, the neonate expresses a short ultradian sleep cycle, with two distinct active and quiet sleep, as well as brief periods of transitional or indeterminate sleep. Qualitative assessment of neonatal sleep is however challenged by biological and environmental variables that influence the expression of EEG-sleep patterns and sleep organization. Developing normative EEG-sleep data with the aid of automated analytic methods, can further improve our understanding of extra-uterine brain development and state organization under stressful or pathological conditions. Based on those developmental biomarkers of normal and abnormal brain function, research can be conducted to support and optimise sleep in the NICU, with the ultimate goal to improve therapeutic interventions and neurodevelopmental outcome.

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“…kangaroo care, light and sound stimulus, prone position, length of recording), which can all influence the quality of sleep expression, and the time variation of the SWC [19,54,56–59]. …”

Section: Qualitative Assessment Of Neonatal Sleepmentioning

confidence: 99%

Review of sleep-EEG in preterm and term neonates

Dereymaeker

Pillay

Vervisch

et al. 2017

Early Human Development

109

117

View full text Add to dashboard Cite

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“…Another study concluded that the use of aEEG should be simultaneous with that of conventional EEG, as in preterm newborns the discontinuous pattern may camouflage seizures 24 . Another factor that may make diagnosis difficult is that the interpretation of the aEEG is very dependent on the user 16 , and most neonatologists are not confident in their ability to interpret an aEEG tracing 36 .…”

Section: Discussionmentioning

confidence: 99%

“…This discontinuous activity may reflects important transient therapeutic pathways for cortical development, which indicates the EEG's efficiency as a sensitive measure of functional maturation 11 and neurological damage in preterm infants 15 . It has already been analyzed that, even though the extrauterine life of neonates influences behavioral patterns during sleep, it does not have an influence on accelerating the maturation of EEG patterns 16,17 .…”

Section: Conventional Electroencephalogrammentioning

confidence: 99%

“…Although the use of software for EEG analysis opens several opportunities for our understanding of premature infant brain activity, its use must still involve human participation, as the equipment is still unable to differentiate artifacts from actual brain activity 16 . The detailed interpretation of the results requires an expert professional, and the complete application of neonatal electrodes requires a trained person 5,14 .…”

Section: Limitations Of Conventional Eegmentioning

confidence: 99%

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Comparison of conventional, amplitude-integrated and geodesic sensor net EEG used in premature neonates: a systematic review

Sousa

Gugelmin

Fernandes

et al. 2019

Arq. Neuro-Psiquiatr.

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The use of methods to evaluate cortical activity in neonates has great importance in modern medicine, as it allows the observation and evaluation of several clinical aspects, which guarantees that the health team has knowledge about possible intervention measures that may be necessary in the treatment of newborns. Objective: This systematic review aimed to compare the main technologies available for the evaluation of brain functions in neonates, among them: the conventional electroencephalogram (EEG), the amplitude-integrated electroencephalogram (aEEG) and the geodesic sensor net EEG. Methods: A search was conducted forarticles from national and international periodicals included in the Web of Science, LILACS, SciELO and Medline electronic databases. Results: The search found 39 among 155 articles of interest and the analyses indicated that, in the clinical environment, the use of both conventional EEG and aEEG is highly recommended, as the combination of their functions allows, for example, a greater number of subclinical seizures to be detected. Conversely, the use of a geodesic sensor net EEG could be of great value, as it allows a large amount of data to be analyzed. Conclusion: This analysis may be useful in studies and research related to diseases and symptoms, such as seizures, a current challenge for neonatal neuromonitoring, as well as aspects of neurological development and functional studies. However, despite many advances in technology, electroencephalography in preterm neonates remains a challenge worldwide and still requires more robust research and efforts towards the best clinical assistance in this extremely early stage of life.

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“…It has been suggested that this adaptation in brain function might be a "physiological" dysmaturity as a result of biological and environmental stress. Nevertheless, there is still some disagreement about these findings, and various authors report a similar intra-and extrauterine maturation of spe-cific EEG parameters (such as interburst interval, IBI, and different wavelength amplitudes) [11] .…”

Section: Introductionmentioning

confidence: 99%

EEG - A Valuable Biomarker of Brain Injury in Preterm Infants

Pavlidis¹,

Lloyd²,

Boylan³

2017

Dev Neurosci

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This review focuses on the role of electroencephalography (EEG) in monitoring abnormalities of preterm brain function. EEG features of the most common developmental brain injuries in preterm infants, including intraventricular haemorrhage, periventricular leukomalacia, and perinatal asphyxia, are described. We outline the most common EEG biomarkers associated with these injuries, namely seizures, positive rolandic sharp waves, EEG suppression/increased interburst intervals, mechanical delta brush activity, and other deformed EEG waveforms, asymmetries, and asynchronies. The increasing survival rate of preterm infants, in particular those that are very and extremely preterm, has led to a growing demand for a specific and shared characterization of the patterns related to adverse outcome in this unique population. This review includes abundant high-quality images of the EEG patterns seen in premature infants and will provide a valuable resource for everyone working in developmental neuroscience.

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In and ex utero maturation of premature infants electroencephalographic indices

Cited by 23 publications

References 18 publications

Review of sleep-EEG in preterm and term neonates

Review of sleep-EEG in preterm and term neonates

Comparison of conventional, amplitude-integrated and geodesic sensor net EEG used in premature neonates: a systematic review

EEG - A Valuable Biomarker of Brain Injury in Preterm Infants

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