In-beam production of labeled compounds

The Chemistry of Positron Emitting Nucleogenic (Hot) Atoms with Regard to Preparation of Labelled Compounds of Practical Utility

“…Therefore, the most useful nuclear reactions for carbon-11 production from a clinical standpoint are the proton and deuteron reactions on natural and enriched boron oxide [34][35][36][37] and the proton reaction on nitrogen [38][39][40][41][42]. Several reviews have appeared in the literature which describe the details and problems in the preparation of carbon-11 labelled intermediates from such targets [9,17,[44][45][46][47][48][49], Table 2 also lists the 12 C( 3 He, 4 He) n C and 12 C(y, n) 11 C reactions because they provide high yields of the radionuclide. The helium-3 reaction [50] has been used in recoil labelling [51 ].…”