In case of obesity, longevity-related mechanisms lead to anti-inflammation

Abstract

The exact mechanisms which contribute to longevity have not been figured out yet. Our aim was to find out a common way for prompting longevity by bringing together the well-known applications such as food restriction, exercise, and probiotic supplementing in an experimental obesity model. Experimental obesity was promoted in a total of 32 young (2 months old) and 32 aged (16 months old) male Wistar albino rats through 8-week cafeteria diet (salami, chocolate, chips, and biscuits). Old and young animals were divided into groups each consisting of eight animals and also divided into four subgroups as obese control, obese food restriction, obese probiotic-fed and obese exercise groups. Probiotic group diet contained 0.05 %w/total diet inactive and lyophilized Lactobacillus casei str. Shirota. The exercise group was subjected to treadmill running 1 h/day, at 21 m/min and at an uphill incline of 15 % for 5 days a week. Food restriction group was formed by giving 40 % less food than the others. The control group was fed regular pellet feed ad libitum. This program was continued for 16 weeks. Blood samples from all the groups were analyzed for fasting glucose, insulin, IGF-1, insulin-like growth factor binding protein 3 (IGFBP-3), interleukin (IL)-6, IL-12, malondialdehyde (MDA), fT3, TT3, fT4, TT4, and liver tissue MDA levels were measured. All applications showed anti-inflammatory effects through the observed changes in the levels of IGFBP-3, IL-6, and IL-12 in the young and old obese rats. While the interventions normally contribute to longevity by recruiting different action mechanisms, anti-inflammatory effect is the only mode of action for all the applications in the obesity model.

Probiotic strains of lactobacilli and bifidobacteria alter pro- and anti-inflammatory cytokines production in rats with monosodium glutamate-induced obesity

“…It was found that the IL-1β, which is primed by high-fat diet (HFD) and is cleaved through the NLRP3 inflammasome complex [21,22], and which production in fat tissue is associated with the TLR4 receptor and nuclear factor-κB activation [23,24], directly influences the peripheral insulin resistance and type II diabetes [20,25,21,26,22]. In our study, glucose and insulin levels in blood serum, and HOMA insulin resistance index [16], as well as IL-1β and IL-12Br40 production were also increased in rats with MSG-induced obesity comparing with intact rats.…”

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

“…These disorders are in addition mainly characterised as inflammatory diseases and inflammation is considered a target for therapy (Qian et al 2010;Weksler et al 2009). For example, in a rat obesity model, mainly anti-inflammatory immune responses were positively associated with longevity (Kaya et al 2014) indicating that reduced inflammation could promote healthy ageing.…”

Inhibitory effect of stinging nettle (Urtica dioica L.) extract on body weight gain in rats on a high-fat diet

“…In the present study, the rats were fed a HFD that consisted of 60% fat for 10 weeks. After 8 weeks of consuming an obesity-inducing diet, the rats that showed a body weight increase of at least 20% when compared to the control group were regarded as obese [ 44 , 45 ]. The present study found that the rats fed a HFD weighed 40% more than the rats in the control group.…”