2014
DOI: 10.1002/pd.4288
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In case you missed it: thePrenatal Diagnosissection editors bring you the most significant advances of 2013

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Cited by 9 publications
(11 citation statements)
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“…These approaches are rapidly moving beyond academic research and into clinical use. For example, it is estimated that in 2013 more than half a million pregnant women underwent noninvasive prenatal testing based on cell-free DNA technology (8). However, detecting differences in gene expression, and not just gene content, may improve our understanding and diagnosis of numerous disease states, including organ failure, inflammatory disease, neurodegenerative disorders, and additional pathological obstetric conditions.…”
mentioning
confidence: 99%
“…These approaches are rapidly moving beyond academic research and into clinical use. For example, it is estimated that in 2013 more than half a million pregnant women underwent noninvasive prenatal testing based on cell-free DNA technology (8). However, detecting differences in gene expression, and not just gene content, may improve our understanding and diagnosis of numerous disease states, including organ failure, inflammatory disease, neurodegenerative disorders, and additional pathological obstetric conditions.…”
mentioning
confidence: 99%
“…It is widely accepted that the placenta is the predominant source of fetal nucleic acid in the maternal plasma but that fetal nucleic acid only accounts for a minority of the cell‐free nucleic acid present . For this reason, the method used to detect this subpopulation of cell‐free nucleic acid must be able to differentiate this from the background maternal nucleic acid .…”
Section: Noninvasive Prenatal Testing (Nipt)mentioning
confidence: 99%
“…These include indeterminate results or test failures, quoted at approximately 3% . These are known to increase with rising maternal body mass index, the presence of maternal chromosomal abnormalities and in confined placental mosaicism, as well as in pregnancies complicated by single twin demise . This has highlighted that NIPT relies on analysis of total cell‐free DNA, which includes both placental (representing fetal) and maternal components .…”
Section: Noninvasive Prenatal Testing (Nipt)mentioning
confidence: 99%
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