In contrast to morphine, buprenorphine enhances macrophage-induced humoral immunity and, as oxycodone, slightly suppresses the effector phase of cell-mediated immune response in mice

Filipczak-Bryniarska, Iwona; Nazimek, Katarzyna; Nowak, Bernadeta; Kozlowski, Michael; Wąsik, Magdalena; Bryniarski, Krzysztof

doi:10.1016/j.intimp.2017.11.039

Cited by 27 publications

(32 citation statements)

References 44 publications

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“…Lymphoproliferation, natural-killer–lymphocyte activity, cytokine production, lymphocyte number are not altered 6. It even seems that buprenorphine enhances B-cells response 7. Furthermore, this treatment was taken for only 2 years and weaned 17 years earlier.…”

Section: Investigationsmentioning

confidence: 99%

Salmonella entericaserovar enteritidis peritonitis with spontaneous intestinal perforation in an immunocompetent patient

et al. 2019

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Few data reported non-typhoidal Salmonella peritonitis in immunocompromised patients. We reported the case of a man without immunosuppression or predisposing factor, who developed Salmonella enterica serovar Enteritidis peritonitis with spontaneous intestinal perforation. After emergent surgery, the patient was transferred to intensive care unit (ICU) because of respiratory, renal and haemodynamic failures. When S. enterica serovar Enteritidis was identified, antibiotics were de-escalated for ceftriaxone and metronidazole for 5 days. No immunosuppression was found. Evolution was favourable, and the patient has been discharged from the ICU on day 8. The originality of this case arises from a perforation peritonitis secondary to S. enterica without any immunosuppression. In absence of non-Typhi Salmonella data, we treated this patient as a typhoid perforation: surgical treatment, antibiotic association and supportive care.

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Section: Investigationsmentioning

confidence: 99%

Salmonella entericaserovar enteritidis peritonitis with spontaneous intestinal perforation in an immunocompetent patient

et al. 2019

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“…In a series of papers the in vivo treatment with oxycodone on macrophage functionality was studied (48,49). Although not completely devoid of effect, oxycodone expressed weaker immunomodulatory properties than morphine and the authors concluded that oxycodone seems to be a safer opioid for chronic therapy.…”

Section: Preclinical Studiesmentioning

confidence: 99%

Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies

et al. 2019

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Suppression of the immune system has been constantly reported in the last years as a classical side effect of opioid drugs. Most of the studies on the immunological properties of opioids refer to morphine. Although morphine remains the "reference molecule," other semisynthetic and synthetic opioids are frequently used in the clinical practice. The primary objective of this review is to analyze the available literature on the immunomodulating properties of opioid drugs different from morphine in preclinical models and in the human. A search strategy was conducted in PubMed, Embase, and the Cochrane databases using the terms "immunosuppression," "immune system," "opioids," "Natural killer cells," "cytokines," and "lymphocytes." The results achieved concerning the effects of fentanyl, methadone, oxycodone, buprenorphine, remifentanil, tramadol, and tapentadol on immune responses in animal studies, in healthy volunteers and in patients are reported. With some limitations due to the different methods used to measure immune system parameters, the large range of opioid doses and the relatively scarce number of participants in the available studies, we conclude that it is not correct to generalize immunosuppression as a common side effect of all opioid molecules.

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“…93 Opioid receptors are commonly expressed in a variety of immune cells, but the responses of macrophages to morphine are opposite to those of buprenorphine and oxycodone. 94 Morphine also suppresses NF-κB activation in macrophages 58 and modulates the activity of glia in the spinal cord, 95 and morphine-induced gut dysbiosis causes TLR2 and TLR4 activation, resulting in a significant increase of IL-6 protein levels. 80 It is important to note that allosteric modulators of muscarinic acetylcholine receptors are being developed that may enable regulation of the addictive and executive dysfunction aspects of substance use disorders.…”

Section: Opioidsmentioning

confidence: 99%

The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models

Hawkins

Casolaro

Brown

et al. 2020

Clin Pharma and Therapeutics

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The complexity of integrating microbiota into clinical pharmacology, environmental toxicology, and opioid studies arises from bidirectional and multiscale interactions between humans and their many microbiota, notably those of the gut. Hosts and each microbiota are governed by distinct central dogmas, with genetics influencing transcriptomics, proteomics, and metabolomics. Each microbiota's metabolome differentially modulates its own and the host's multi‐omics. Exogenous compounds (e.g., drugs and toxins), often affect host multi‐omics differently than microbiota multi‐omics, shifting the balance between drug efficacy and toxicity. The complexity of the host‐microbiota connection has been informed by current methods of in vitro bacterial cultures and in vivo mouse models, but they fail to elucidate mechanistic details. Together, in vitro organ‐on‐chip microphysiological models, multi‐omics, and in silico computational models have the potential to supplement the established methods to help clinical pharmacologists and environmental toxicologists unravel the myriad of connections between the gut microbiota and host health and disease.

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In contrast to morphine, buprenorphine enhances macrophage-induced humoral immunity and, as oxycodone, slightly suppresses the effector phase of cell-mediated immune response in mice

Cited by 27 publications

References 44 publications

Salmonella entericaserovar enteritidis peritonitis with spontaneous intestinal perforation in an immunocompetent patient

Salmonella entericaserovar enteritidis peritonitis with spontaneous intestinal perforation in an immunocompetent patient

Do All Opioid Drugs Share the Same Immunomodulatory Properties? A Review From Animal and Human Studies

The Microbiome and the Gut‐Liver‐Brain Axis for Central Nervous System Clinical Pharmacology: Challenges in Specifying and Integrating In Vitro and In Silico Models

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