In Control of Motion:  From Molecular Switches to Molecular Motors

Feringa, Bernard

doi:10.1021/ar0001721

Cited by 568 publications

(356 citation statements)

References 35 publications

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“…T he development of nanoscale molecular devices that exhibit controlled movement upon energy input advances progressively (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In the past decade, a spectrum of ingeniously designed molecular structures, ranging from artificial muscles (12) to molecular cars (13), was introduced.…”

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confidence: 99%

Optimizing rotary processes in synthetic molecular motors

Geertsema

Molen

Martens

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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We deal with the issue of quantifying and optimizing the rotation dynamics of synthetic molecular motors. For this purpose, the continuous four-stage rotation behavior of a typical light-activated molecular motor was measured in detail. All reaction constants were determined empirically. Next, we developed a Markov model that describes the full motor dynamics mathematically. We derived expressions for a set of characteristic quantities, i.e., the average rate of quarter rotations or ''velocity,'' V, the spread in the average number of quarter rotations, D, and the dimensionless Pé clet number, Pe ‫؍‬ V/D. Furthermore, we determined the rate of full, four-step rotations (⍀ eff), from which we derived another dimensionless quantity, the ''rotational excess,'' r.e. This quantity, defined as the relative difference between total forward (⍀ ؉) and backward (⍀؊) full rotations, is a good measure of the unidirectionality of the rotation process. Our model provides a pragmatic tool to optimize motor performance. We demonstrate this by calculating V, D, Pe, ⍀ eff, and r.e. for different rates of thermal versus photochemical energy input. We find that for a given light intensity, an optimal temperature range exists in which the motor exhibits excellent efficiency and unidirectional behavior, above or below which motor performance decreases. Markov model ͉ unidirectional rotation

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confidence: 99%

Optimizing rotary processes in synthetic molecular motors

Geertsema

Molen

Martens

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

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“…Two of the most interesting molecular machines synthesized to date are light-driven small organic molecules: a linear shuttle [11], and the rotary motor shown in Fig. 1 [23]. Under irradiation with a suitable wavelength in the visible range one part of Feringa's molecule (the rotor, at the top of the figure) rotates continuously with respect to a fixed part (the stator, at the bottom of the figure) around the carbon-carbon double bond shown at the center of the figure.…”

Section: Actuators 1) Artificial Molecular Machinesmentioning

confidence: 99%

Nanorobots, NEMS, and Nanoassembly

2003

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“…They attracted an interest of many researchers in an effort to create artificial analogs with similar properties. [6][7][8][9][10][11][12][13][14][15][16] There have been many theoretical insights into mechanisms and properties of molecular machines and artificial molecular rotors and motors. Experimentally, the possibility to induce an unidirectional rotation of molecular systems by periodic perturbations has been observed in catenane systems.…”

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confidence: 99%

Directed motion of periodically driven molecular motors: A graph-theoretical approach

Akimov

Mandal

Chernyak

et al. 2013

The Journal of Chemical Physics

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We propose a numerical algorithm for calculation of quantized directed motion of a stochastic system of interacting particles induced by periodic changes of control parameters on the graph of microstates. As a main application, we consider models of catenane molecular motors, which demonstrated the possibility of a similar control of directed motion of molecular components. We show that our algorithm allows one to calculate the motion of a system in the space of its microstates even when the considered phase space is combinatorially large (∼1 × 10 6 microscopic states). Several general observations are made about the structure of the phase diagram of the systems studied, which may be used for rational design and efficient control of new generations of molecular motors.

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In Control of Motion: From Molecular Switches to Molecular Motors

Cited by 568 publications

References 35 publications

Optimizing rotary processes in synthetic molecular motors

Optimizing rotary processes in synthetic molecular motors

Nanorobots, NEMS, and Nanoassembly

Directed motion of periodically driven molecular motors: A graph-theoretical approach

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