In-depth assessment of health-related quality of life after in-hospital cardiac arrest

Schluep, Marc; Endeman, Henrik; Gravesteijn, Benjamin; Kuijs, Cees; Blans, Michiel J.; Bogaard, Bas van den; Gemert, A.W.M.M. Koopman Van; Hukshorn, Chris J.; Meer, Bernard; Knook, A.H.M.; Melsen, Trudy van; Peters, R. H. J.; Simons, Koen S.; Vermeijden, Jan Wytze; Wils, Evert‐Jan; Stolker, Robert Jan; Hoeks, Sanne E.

doi:10.1016/j.jcrc.2021.11.008

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…The use of the CPC score in cardiac arrest research is increasingly scrutinized as it may not reflect functional outcome. 20 In general, CPC scores of 1 and 2 are classified as good outcome after resuscitation. While these patients are survivors with good neurological function, this does not necessary mean they experience a good quality of life or good functional outcome.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

van de Koolwijk,

Delnoij,

Suverein

et al. 2024

Resuscitation Plus

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Section: Discussionmentioning

confidence: 99%

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

van de Koolwijk,

Delnoij,

Suverein

et al. 2024

Resuscitation Plus

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“…Schluep M. et al demonstrated an improvement in the quality of life among cardiac arrest survivors from 3 months to 1 year after hospital discharge, as assessed using the visual analog scale of the EQ-5D-5L. 23 Posttraumatic symptoms are prevalent in cardiac arrest survivors, and they can persist even years after the initial cardiac arrest event. These symptoms are associated with poorer quality of life in both survivors and informal caregivers.…”

Section: Discussionmentioning

confidence: 99%

Work Status, Functional Recovery, and Quality of Life of Cardiac Arrest Survivors After Hospital Discharge

Wu,

Chen,

Huang

et al. 2023

Preprint

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Background To investigate the work status, neurological recovery, and quality of life of cardiac arrest survivors within 1 year after hospital discharge. Methods A retrospective single center study included 71 non-traumatic adult cardiac arrest patients between 2017 and 2020, who survived more than 1 year after hospital discharge and agreed to participate the study. Questionnaire interviews through telephone visits were conducted with the enrolled patients, assessing their work status, neurological recovery, and quality of life at 3 months and 1 year after hospital discharge. Additionally, their use of medical services was also collected. Results Of the enrolled patients, 67 (94.4%) had a cerebral performance category (CPC) of 1 at discharge and the majority of patients (90.1%) returned home. Sixty-seven patients (94.4%) returned for outpatient visits at a median time of 6 days, 23 patients (32.4%) visited the ER at a median time of 74 days, and 22 patients (31.0%) were readmitted to the hospital at a median time of 58 days. In terms of mobility, self-care, usual activities, pain/discomfort, and health state assessed using the EQ-5D-5L, a significant decrease in impairment was observed from 3 months to 1 year. Moreover, patients demonstrated improved work status as well as improved scores for overall quality of life, general health, physical, psychological, social relations, and environmental status evaluated using the WHOQOL-BREF. Conclusions Within 1 year following hospital discharge, a considerable number of cardiac arrest survivors require medical support. However, a continual improvement in work status and quality of life were observed.

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“…Thus, the assessments herein are focused on neurologic function and their application to cardiopulmonary function may have limitations. Though the CPC scale and HRQOL may not be well correlated, 34 the substitution of neurologic status appears to be an acceptable alternative approach for evaluating the quality of life even among cardiac arrest survivors 23,35,36 . In addition, as most patients were assigned with a utility of either 0 or 1, the difference between the calculation of QALY and LYS is small.…”

Section: Discussionmentioning

confidence: 99%

“…33 Thus, the assessments herein are focused on neurologic function and their application to cardiopulmonary function may have limitations. Though the CPC scale and HRQOL may not be well correlated, 34 the substitution of neurologic status appears to be an acceptable alternative approach for evaluating the quality of life even F I G U R E 3 Cost-effectiveness acceptability curves from (A) all patients, (B-F) 1st quintile to 5th quintile (from low risk to high risk). The cost-effectiveness ratio (CER) (x-axis) values when acceptability (y-axis) equals to 0.025 and 0.975 represents the lower limit (2.5%) and the higher limit (97.5%) of the 95% confidence intervals of the cost-effectiveness ratio among cardiac arrest survivors.…”

Section: Extracorporeal Life Support Organization Adult Respiratorymentioning

confidence: 99%

Risk stratification and cost‐effectiveness analysis of adult patients receiving extracorporeal membrane oxygenation

Liao

Lin

Tsai

et al. 2022

Evaluation Clinical Practice

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Rationale, Aims, and Objectives A more effective allocation of critical care resources is important as the cost of intensive care increases. A model has been developed to predict the probability of in‐hospital death among patients who received extracorporeal membrane oxygenation (ECMO). Cost‐effectiveness analyses (CEA) were performed regarding the relationship between hospitalization expenses and predicted survival outcomes. Methods Adult patients who received ECMO in a medical center in Taiwan (2005–2016) were included. A logistic regression model was applied to a spectrum of clinical measures obtained before and during ECMO institutions to identify the risk variables for in‐hospital mortality. CEA were reported as a predictive risk in quintiles and defined as the cost of each quality‐adjusted life‐year (QALY). The distribution of the cost‐effectiveness ratio (CER) was measured by the ellipse and acceptability curve methods. Results A total of 919 patients (659 males, mean age: 53.7 years) were enrolled. Ten variables emerged as significant predictors of in‐hospital death. The area under the receiver operating characteristic curve was 0.75 (95% confidence interval: 0.72–0.79). In‐hospital and total follow‐up times were 40,366 and 660,205 person‐days, respectively. The total in‐hospital expense was $31,818,701 USD and the total effectiveness was 1687.3 QALY. For the lowest to the highest risk quintile, the mean mortality risks were 0.30, 0.48, 0.61, 0.75, and 0.88, and mean adjusted CER were $24,230, $43,042, $54,929, $84,973, and $149,095 per QALY, respectively. Conclusions The efficient allocation of limited and costly resources is most important when one is forced to decide between groups of critically ill patients. The current analyses of ECMO outcomes should assist in identifying candidates with the greatest prospect for survival while avoiding futile treatments.

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In-depth assessment of health-related quality of life after in-hospital cardiac arrest

Cited by 4 publications

References 33 publications

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

Health-related quality of life one year after refractory cardiac arrest treated with conventional or extracorporeal CPR; a secondary analysis of the INCEPTION-trial

Work Status, Functional Recovery, and Quality of Life of Cardiac Arrest Survivors After Hospital Discharge

Risk stratification and cost‐effectiveness analysis of adult patients receiving extracorporeal membrane oxygenation

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