In-depth evaluation of nutritive, chemical constituents and anti-glycemic properties of jackfruit (Artocarpus heterophyllus Lam) clonal accessions with flake colour diversity from Eastern Sub-Himalayan plains of India

Natta, Suman; Pal, Kumaresh; Alam, Bharath Kumar; Mondal, Debayan; Dutta, Sunil; Sahana, Nandita; Mandal, Somnath; Bhowmick, Nilesh; Das, Sudipta; Mondal, Prithusayak; Pandit, Goutam K.; Paul, Prodyut Kumar; Choudhury, Ashok

doi:10.1016/j.foodchem.2022.135098

Cited by 12 publications

(3 citation statements)

References 38 publications

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“…Anethole is another phenylpropanoid found in Urtica dioica [109] and Foeniculum vulgare [103]. This active compound is reported to suppress diabetic nephropathy in streptozotocin-induced diabetic rats by decreasing blood glucose levels and downregulating angiotensin II receptor (AT1R) and TGF-β1 expression [114]. The phenylpropene namely estragole (methyl chavicol) acts as an enzyme inhibitor against α-amylase, lipase, and tyrosinase and serves as a potent antioxidant agent that can improve diabetes [115,116].…”

Section: Active Compounds Of Ecuadorian Medicinal Plants and Their An...mentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Preprint

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Diabetes mellitus (DM) is a metabolic disorder characterized by the deficiency of insulin production and is one of the concerning health problems worldwide, especially in developing countries. Considering the systemic toxicity associated with current antidiabetic medications and their limited efficacy, there is an urgent need to discover new plant-based natural antidiabetics. Since time immemorial, medicinal plants have played an important role in the management of health disorders. In recent years, herbal medicine has experienced exponential growth in popularity worldwide, owing to its natural origin and fewer side effects, appealing to both developing and developed nations. Ecuador has a rich cultural history in ethnobotany that plays a crucial role in their people's lives. Several Ecuadorian medicinal plants have hypoglycemic or an-ti-hyperglycemic properties that are rich with bioactive phytochemicals. These medicinal plants were extensively used in traditional medicine preparation in Ecuador for many decades to treat diabetes because of their cost-effectiveness, available traditional knowledge, and low toxicity. Many Ecuadorian medicinal plants are reported to have antidiabetic properties that reduce blood sugar levels, and oxidative stress, regulate intestinal function, improve insulin resistance, inhibit α-amylase and α-glucosidase, lower gluconeogenic enzymes, stimulate glucose uptake mechanisms, and play an important role in glucose and lipid metabolism, yet there is a substantial lack of integrated approach between the existing ethnomedicinal practice and pharmacological research. Therefore, this review aims to discuss and explore the traditional medicinal plants used in Ecuador for treating DM and their bioactive phytochemicals, which are mainly responsible for their anti-diabetic properties.

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Section: Active Compounds Of Ecuadorian Medicinal Plants and Their An...mentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Preprint

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“…2-Heptadecenal is an aldehyde found in Artocarpus altilis [ 95 ], which acts as a natural inhibitor of the α-amylase and α-glucosidase enzymes. A study by Natta et al (2023) [ 124 ] reported antiglycemic properties of Artocarpus heterophyllus , in which they found 2-heptadecenal to be the major compound responsible for this activity. Anethole is another phenylpropanoid found in Urtica dioica [ 125 ] and Foeniculum vulgare [ 115 ].…”

Section: Bioactive Compounds Of Ecuadorian Medicinal Plants and Their...mentioning

confidence: 99%

“…n-Hexadecanoic acid Fatty acid α-amylase and α-glucosidase inhibitory activity and antioxidant activity [122] Ellagic acid Phenol α-amylase inhibitory activity and antioxidant activity, stimulate insulin secretion and decrease glucose intolerance [134] 2-Heptadecenal Aldehyde α-amylase and α-glucosidase inhibitory activity [124] Baccharis genistelloides Cirsimaritin Flavonoid Reduces elevated levels of serum glucose in diabetic rats and abrogates the increase in serum insulin [100] Cirsiliol Flavonoid Hypoglycaemic effect [101] Hispidulin Flavonoid Stimulates glucagon-like peptide-1 and suppresses hepatic glucose production [102] Genkwanin Flavonoid α-amylase inhibitory activity and antioxidant activity [103] Apigenin Flavonoid Facilitates glucose-stimulated insulin secretion and prevents ER stress-mediated β-cell apoptosis in the pancreas [104] Bryophyllum gastonis-bonnieri…”

Section: Artocarpus Altilismentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Plants

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Diabetes mellitus (DM) is a global health concern characterized by a deficiency in insulin production. Considering the systemic toxicity and limited efficacy associated with current antidiabetic medications, there is the utmost need for natural, plant-based alternatives. Herbal medicines have experienced exponential growth in popularity globally in recent years for their natural origins and minimal side effects. Ecuador has a rich cultural history in ethnobotany that plays a crucial role in its people’s lives. This study identifies 27 Ecuadorian medicinal plants that are traditionally used for diabetes treatment and are prepared through infusion, decoction, or juice, or are ingested in their raw forms. Among them, 22 plants have demonstrated hypoglycemic or anti-hyperglycemic properties that are rich with bioactive phytochemicals, which was confirmed in several in vitro and in vivo studies. However, Bryophyllum gastonis-bonnieri, Costus villosissimus, Juglans neotropica, Pithecellobium excelsum, and Myroxylon peruiferum, which were extensively used in traditional medicine preparation in Ecuador for many decades to treat diabetes, are lacking in pharmacological elucidation. The Ecuadorian medicinal plants used to treat diabetes have been found to have several bioactive compounds such as flavonoids, phenolics, fatty acids, aldehydes, and terpenoids that are mainly responsible for reducing blood sugar levels and oxidative stress, regulating intestinal function, improving insulin resistance, inhibiting α-amylase and α-glucosidase, lowering gluconeogenic enzymes, stimulating glucose uptake mechanisms, and playing an important role in glucose and lipid metabolism. However, there is a substantial lack of integrated approaches between the existing ethnomedicinal practices and pharmacological research. Therefore, this review aims to discuss and explore the traditional medicinal plants used in Ecuador for treating DM and their bioactive phytochemicals, which are mainly responsible for their antidiabetic properties. We believe that the use of Ecuadorian herbal medicine in a scientifically sound way can substantially benefit the local economy and industries seeking natural products.

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Jackfruit (Artocarpus heterophyllus): An Overview of Nutritional and Functional Food Properties

Khan,

Hossain,

Qadeer

et al. 2023

Neglected Plant Foods of South Asia

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In-depth evaluation of nutritive, chemical constituents and anti-glycemic properties of jackfruit (Artocarpus heterophyllus Lam) clonal accessions with flake colour diversity from Eastern Sub-Himalayan plains of India

Cited by 12 publications

References 38 publications

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Jackfruit (Artocarpus heterophyllus): An Overview of Nutritional and Functional Food Properties

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