In diabetic Charcot neuroarthropathy impaired microvascular function is related to long lasting metabolic control and low grade inflammatory process

Araszkiewicz, Aleksandra; Soska, J; Borucka, Katarzyna; Olszewska, Marta; Niedźwiecki, Paweł; Wierusz‐Wysocka, Bogna; Zozulińska−Ziółkiewicz, Dorota

doi:10.1016/j.mvr.2015.07.008

Cited by 12 publications

(25 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several other authors have found the same results in T1D and T2D31, whereas others have found no difference between diabetics and control subjects1532 and, in one study, a surprising increase in PORH response33. The lack of difference between diabetics and control subjects could be due to a higher age of the population studied32 or a higher duration of diabetes15 that may have minimized the difference between the populations. The test used in our study enables us to assess the sensory nerves, the large-conductance calcium activated potassium (BK CA ) channels and EDHF, especially the 5,6-epoxyeicosatrienoic acid pathway3435.…”

Section: Discussionmentioning

confidence: 76%

See 1 more Smart Citation

Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes

Marche

Dubois

Ábrahám

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Microvascular dysfunction may have an early onset in type 1 diabetes (T1D) and can precede major complications. Our objectives were to assess the endothelial-dependent (acetylcholine, ACh; and post-occlusive hyperemia, PORH), non-endothelial-dependent (sodium nitroprusside, SNP) and neurovascular-dependent (local heating, LH and current induced vasodilation, CIV) microcirculatory vasodilation in T1D patients compared with matched control subjects using a laser speckle contrast imager. Seventeen T1D patients - matched with 17 subjects according to age, gender, Body-Mass-Index, and smoking status - underwent macro- and microvascular investigations. The LH early peak assessed the transient receptor potential vanilloid type 1 channels (TRPV1) mediated vasodilation, whereas the plateau assessed the Nitirc-Oxyde (NO) and endothelium-derived hyperpolarizing factor (EDHF) pathways. PORH explored sensory nerves and (EDHF), while CIV assessed sensory nerves (C-fibers) and prostaglandin-mediated vasodilation. Using neurological investigations, we observed that C-fiber and A-delta fiber functions in T1D patients were similar to control subjects. PORH, CIV, LH peak and plateau vasodilations were significantly decreased in T1D patients compared to controls, whereas there was no difference between the two groups for ACh and SNP vasodilations. Neurovascular microcirculatory vasodilations (C-fibers and TRPV 1-mediated vasodilations) are impaired in TD1 patients whereas no abnormalities were found using clinical neurological investigations. Clinicaltrials: No. NCT02538120.

show abstract

Section: Discussionmentioning

confidence: 76%

“…Several authors have shown that the EDHF pathway is altered in diabetes363738. This decrease of the local thermal plateau response can be widely found in the literature but the mechanism involved in such a decrease remains to be clarified12143239.…”

Section: Discussionmentioning

confidence: 94%

Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes

Marche

Dubois

Ábrahám

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Microvascular measures were obtained at the dorsal foot [ 19 , 22 – 24 ], plantar hallux [ 18 , 21 ] and the plantar foot [ 20 ]. Studies used either one method or multiple methods of measuring cutaneous microvascular reactivity via laser-Doppler fluxmetry, though in total five used thermal hyperaemia [ 18 , 21 – 24 ].…”

Section: Resultsmentioning

confidence: 99%

“…Four studies provided details of sex of participants (n = 5-54 males and n = 7-16 females) [18,19,21,22] and three did not [20,23,24]. Microvascular measures were obtained at the dorsal foot [19,[22][23][24], plantar hallux [18,21] and the plantar foot [20]. Studies used either one method or multiple methods of measuring cutaneous microvascular reactivity via laser-Doppler fluxmetry, though in total five used thermal hyperaemia [18,[21][22][23][24].…”

Section: Characteristics and Overview Of Included Studiesmentioning

confidence: 99%

Cutaneous microvascular reactivity in Charcot neuroarthropathy: a systematic review and meta‐analysis

Chan

Casey

Peterson

et al. 2022

Journal of Foot and Ankle Research

View full text Add to dashboard Cite

Background To systematically evaluate the literature investigating the relationship between cutaneous microvascular reactivity in the foot of adults with diabetes-related Charcot neuroarthropathy compared to a non-Charcot adult control group. Methods A systematic search was conducted to June 2021 using the biomedical databases EBSCO Megafile Ultimate, Cochrane Library and EMBASE. Original research conducting comparative investigation of cutaneous microvascular reactivity in the foot of adults with diabetes and any pattern of acute or chronic Charcot neuroarthropathy and any non-Charcot adult control groups were included. A modified Critical Appraisal Skills Programme tool was used for quality appraisal. Cutaneous microvascular reactivity in diabetes-related Charcot neuroarthropathy data were synthesised and meta-analysis conducted where possible. Results The search strategy identified 1,684 articles, with seven eligible for inclusion. Included studies used various methodologies and equipment to assess cutaneous microvascular reactivity in 553 participants (162 with Charcot neuroarthropathy). Cutaneous microvascular reactivity in Charcot neuroarthropathy groups was impaired compared to uncomplicated diabetes groups. Meta-analysis investigating the difference in response to thermal hyperaemia demonstrated a significant difference in cutaneous microvascular reactivity between Charcot neuroarthropathy and peripheral neuropathy with a large, pooled effect size (SMD 1.46 95% CI: 0.89–2.02) and low heterogeneity (I2 = 4%, T2 = 0.01) indicating that the cutaneous microvascular response is more impaired in peripheral neuropathy than in Charcot neuroarthropathy. Conclusions Charcot neuroarthropathy is associated with greater cutaneous microvascular reactivity in the periphery relative to diabetes cohorts with diabetes-related peripheral neuropathy alone. It is unknown if this occurs prior to, or as a result of, Charcot neuroarthropathy.

show abstract

“…Araszkiewicz et al . [ 71 ] found a relation between SAF and microvascular reactivity, as assessed by peak flow after reactive hyperaemia measured by laser Doppler flow. Furthermore, Ueno et al .…”

Section: Saf and Clinical Markers Of Cardiovascular Diseasementioning

confidence: 99%

Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

Fokkens

Smit

2016

Glycoconj J

View full text Add to dashboard Cite

Glycation is important in the development of complications of diabetes mellitus and may have a central role in the well-described glycaemic memory effect in developing these complications. Skin fluorescence has emerged over the last decade as a non-invasive method for assessing accumulation of advanced glycation endproducts. Skin fluorescence is independently related to micro- and macrovascular complications in both type 1 and type 2 diabetes mellitus and is associated with mortality in type 2 diabetes. The relation between skin fluorescence and cardiovascular disease also extends to other conditions with increased tissue AGE levels, such as renal failure. Besides cardiovascular complications, skin fluorescence has been associated, more recently, with other prevalent conditions in diabetes, such as brain atrophy and depression. Furthermore, skin fluorescence is related to past long-term glycaemic control and clinical markers of cardiovascular disease. This review will discuss the technique of skin fluorescence, its validation as a marker of tissue AGE accumulation, and its use as a clinical tool for the prediction of long-term complications in diabetes mellitus.

show abstract

In diabetic Charcot neuroarthropathy impaired microvascular function is related to long lasting metabolic control and low grade inflammatory process

Cited by 12 publications

References 28 publications

Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes

Neurovascular microcirculatory vasodilation mediated by C-fibers and Transient receptor potential vanilloid-type-1 channels (TRPV 1) is impaired in type 1 diabetes

Cutaneous microvascular reactivity in Charcot neuroarthropathy: a systematic review and meta‐analysis

Skin fluorescence as a clinical tool for non-invasive assessment of advanced glycation and long-term complications of diabetes

Contact Info

Product

Resources

About