In Doxorubicin-Adapted Hodgkin Lymphoma Cells, Acquiring Multidrug Resistance and Improved Immunosuppressive Abilities, Doxorubicin Activity Was Enhanced by Chloroquine and GW4869

Casagrande, Naike; Borghese, Cinzia; Avanzo, Michele; Aldinucci, Donatella

doi:10.3390/cells12232732

Cited by 1 publication

(3 citation statements)

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“…Doxorubicin is one of the current treatment regimens in HL, and their findings indicate that autophagy functions as a cellular mechanism to rescue tumor cells from apoptosis [ 27 ]. Confirming previous findings, co-administration of autophagy inhibitors was shown to reverse doxorubicin resistance in doxorubicin-resistant HL cells [ 29 ]. An extensive study on multiple HL cell lines found that inhibiting autophagy causes an increase in cell death compared to non-malignant B-cells [ 30 ].…”

Section: Resultssupporting

confidence: 85%

“…The results from our review showed studies supporting both sides of the argument. Autophagy was shown to have protective effects on cancer cells [ 27 , 29 , 30 , 33 ] but was also essential for cell death [ 28 , 31 , 32 , 36 ]. The conflicting conclusion reflects autophagy's complex cellular function.…”

Section: Discussionmentioning

confidence: 99%

“…None of these studies directly examined the effects of autophagy on HL. However, from the results of our scoping review, we can derive with some confidence that since the autophagy proteins were also highly expressed in HL cells, correlated with treatment recurrence, and influenced chemosensitivity, the function of autophagy in HL is similar [ 27 , 29 , 30 , 33 ]. These previous findings supported the notion of autophagy as one key player in the DNA damage response [ 53 , 106 ].…”

Section: Discussionmentioning

confidence: 99%

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Chemotherapy’s effects on autophagy in the treatment of Hodgkin’s lymphoma: a scoping review

Wahyudianingsih,

Sanjaya,

Jonathan

et al. 2024

Discov Onc

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Background Classical Hodgkin Lymphomas (HL) are a unique malignant growth with an excellent initial prognosis. However, 10–30% of patients will still relapse after remission. One primary cellular function that has been the focus of tumor progression is autophagy. This process can preserve cellular homeostasis under stressful conditions. Several studies have shown that autophagy may play a role in developing HL. Therefore, this review aimed to explore chemotherapy’s effect on autophagy in HL, and the effects of autophagy on HL. Methods A scoping review in line with the published PRISMA extension for scoping reviews (PRISMA-ScR) was conducted. A literature search was conducted on the MEDLINE database and the Cochrane Central Register of Controlled Trials (CENTRAL). All results were retrieved and screened, and the resulting articles were synthesized narratively. Results The results showed that some cancer chemotherapy also induces autophagic flux. Although the data on HL is limited, since the mechanisms of action of these drugs are similar, we can infer a similar relationship. However, this increased autophagy activity may reflect a mechanism for increasing tumor growth or a cellular compensation to inhibit its growth. Although evidence supports both views, we argued that autophagy allowed cancer cells to resist cell death, mainly due to DNA damage caused by cytotoxic drugs. Conclusion Autophagy reflects the cell’s adaptation to survive and explains why chemotherapy generally induces autophagy functions. However, further research on autophagy inhibition is needed as it presents a viable treatment strategy, especially against drug-resistant populations that may arise from HL chemotherapy regimens.

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Section: Resultssupporting

confidence: 85%