Abstract:Inflammatory signs are more frequent in EOA than in non-EOA, not only in erosive joints but also in non-erosive joints, suggesting an underlying systemic cause for erosive evolution.
“…Earlier, cross-sectional studies have been done showing associations between inflammatory features as assessed by ultrasound or MRI and structural damage2 8 which support the observations of this study. Risk factors for structural damage have been more widely investigated in patients with OA of the knee.…”
Inflammatory features, especially when persistently present, are independently associated with radiological progression in HOA after 2.3 years, indicating a role of inflammation in the aetiology of structural damage in HOA.
“…Earlier, cross-sectional studies have been done showing associations between inflammatory features as assessed by ultrasound or MRI and structural damage2 8 which support the observations of this study. Risk factors for structural damage have been more widely investigated in patients with OA of the knee.…”
Inflammatory features, especially when persistently present, are independently associated with radiological progression in HOA after 2.3 years, indicating a role of inflammation in the aetiology of structural damage in HOA.
“…A subset of patients develops erosive hand OA, which is often associated with more inflammatory findings 2. Hence, erosive hand OA is often called ‘inflammatory OA’ 3.…”
BMLs, synovitis and JSN were the strongest predictors for radiographic progression. Malalignment was associated with incident erosions only. Future studies should explore whether reducing BMLs and inflammation can decrease the risk of structural progression.
“…In addition to morphologic changes, Doppler techniques enable evaluation of synovial vascularity, a surrogate of inflammatory activity 65,66 . A recent study demonstrated that ultrasound-detected synovial thickening and power Doppler signals were more frequently found in erosive hand OA compared to non-erosive hand OA 69 . It should be noted that, while color Doppler ultrasound is a useful technique for the detection of synovitis, it cannot differentiate between synovitis in OA and other arthritides based on the findings of color Doppler signals alone 70 .…”
MRI and ultrasound are currently the most useful imaging modalities for evaluation of non-osteochondral tissues in OA. MRI evaluation of any tissue needs to be performed using appropriate MR pulse sequences. Ultrasound may be particularly useful for evaluation of small joints of the hand. Nuclear medicine and CT play a limited role in imaging of non-osteochondral tissues in OA.
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