In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C. elegans

Abstract

In-gel SOD assay reveals SOD-2 is the single active, water-soluble SOD enzyme in C.

Mitochondrial succinate dehydrogenase function is essential for sperm motility and male fertility

“… 58 Another antioxidant gene, sod-2 , also displayed the same pattern of significant downregulation in starvation, with a visible but not significant upregulation after heat shock ( Figure S5 ). sod-2 is thought to be the only mitochondrially active superoxide dismutase (SOD) in C. elegans adults 59 and is known to be crucial in C. elegans sperm activation. 60 Thus, antioxidant pathways are stress responsive, and stress-induced upregulation of these antioxidant genes could be related to the occasional fertility reversion in sdha-2 mutant animals.…”