In healthy adults, resistant maltodextrin produces a greater change in fecal bifidobacteria counts and increases stool wet weight: a double-blind, randomized, controlled crossover study

Burns, Alyssa M.; Solch, Rebecca J.; Dennis-Wall, Jennifer C.; Ukhanova, Maria; Nieves, Carmelo; Mai, Volker; Christman, Mary C.; Gordon, Dennis T.; Langkamp‐Henken, Bobbi

doi:10.1016/j.nutres.2018.09.007

Cited by 29 publications

(23 citation statements)

References 26 publications

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“…Some bacterial genera were significantly altered by the ingestion of RMD. Previous studies have reported that Bifidobacterium increase following an ingestion of RMD [18]. Bifidobacterium have been reported to produce mainly one SCFA, acetic acid, in the intestinal lumen.…”

Section: Discussionmentioning

confidence: 99%

Resistant maltodextrin intake reduces virulent metabolites in the gut environment: randomized control study in a Japanese cohort

Nishimoto

Mizuguchi

Mori

et al. 2020

Preprint

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Objective: In recent years, there have been many reports on the effects of prebiotics on intestinal health. In particular, consuming resistant maltodextrin (RMD) has been reported to be beneficial. However, there has been no comprehensive quantification of the effect of RMD on the intestinal environment. Therefore, this study aimed to quantify the effects of RMD on the intestine, especially the intestinal microbiome and metabolome profiles. Design: A randomized, double-blind controlled trial was conducted in 29 Japanese subjects with relatively high hemoglobin A1c (HbA1c). Subjects consumed RMD or placebo twice per day for 24 weeks. Blood and fecal samples were collected before and after intake. The intestinal environment was assessed by a metabologenomics approach combined with 16S rRNA gene-based microbiome and mass spectrometry-based metabologenomics analyses. Results: The intake of RMD increased the levels of Bifidobacterium and Fusicatenibacter, and decreased deoxycholate. In addition, intake of the RMD lowered the levels of some virulent metabolites, such as imidazole propionate and trimethylamine, in subjects with an initially high amount of those metabolites. Conclusion: RMD may have beneficial effects on the gut environment such as commensal microbiota modulation and reduction of virulence metabolites, known as a causative factor in metabolic disorders. However, its effect partially depends on the gut environmental baseline.

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Section: Discussionmentioning

confidence: 99%

Resistant maltodextrin intake reduces virulent metabolites in the gut environment: randomized control study in a Japanese cohort

Nishimoto

Mizuguchi

Mori

et al. 2020

Preprint

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“…In addition, Firmicutes and Proteobacteria levels decreased over the treatment period compared to basal values, whereas no changes were observed in other beneficial bacteria groups, such as Lactobacillus or F. prausnitzii [ 59 ]. With respect to candidate prebiotic fibers, the intake of resistant maltodextrin and resistant potato starch (RPS) has been also associated with higher levels of Bifidobacterium compared to the control group in several studies [ 62 , 63 , 64 ], whereas B. ruminantium [ 63 ] and Bifidobacterium fecale/adolescentis/stercoris levels increased after the intake of RPS [ 67 ]. In addition, some butyrate-producing bacteria, such as Ruminococcus , showed different responses to candidate prebiotic fibers depending on the type of fiber source.…”

Section: Dietmentioning

confidence: 99%

Microbiota and Lifestyle: A Special Focus on Diet

et al. 2020

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It is widely known that a good balance and healthy function for bacteria groups in the colon are necessary to maintain homeostasis and preserve health. However, the lack of consensus on what defines a healthy gut microbiota and the multitude of factors that influence human gut microbiota composition complicate the development of appropriate dietary recommendations for our gut microbiota. Furthermore, the varied response to the intake of probiotics and prebiotics observed in healthy adults suggests the existence of potential inter- and intra-individual factors, which might account for gut microbiota changes to a greater extent than diet. The changing dietary habits worldwide involving consumption of processed foods containing artificial ingredients, such as sweeteners; the coincident rise in emotional disorders; and the worsening of other lifestyle habits, such as smoking habits, drug consumption, and sleep, can together contribute to gut dysbiosis and health impairment, as well as the development of chronic diseases. This review summarizes the current literature on the effects of specific dietary ingredients (probiotics, prebiotics, alcohol, refined sugars and sweeteners, fats) in the gut microbiota of healthy adults and the potential inter- and intra-individual factors involved, as well as the influence of other potential lifestyle factors that are dramatically increasing nowadays.

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“…Miyazato et al (2016) found that continuous intake of soluble dietary fiber enhances the intestinal immune response in a dose-dependent manner, resulting in increased total immunoglobulin A (IgA) levels and production of short-chain fatty acids (SCFAs) in the intestinal tract of mice. Furthermore, the soluble fiber resistant maltodextrin is a slowly fermentable prebiotic fiber that affects the gut microbiota, producing a marked change in the Bifidobacteria count in humans (Burns et al 2018). Dietary supplementation with prebiotics can effectively increase the number and proportion of intestinal beneficial bacteria (Gibson 1999), prevent intestinal inflammation, and improve nutrient metabolism (Goetze et al 2008).…”

Section: Electronic Supplementary Materialsmentioning

confidence: 99%

Pyrodextrin enhances intestinal function through changing the intestinal microbiota composition and metabolism in early weaned piglets

Zhu

Liao

et al. 2020

Appl Microbiol Biotechnol

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Pyrodextrin (PD) is prepared from starch by heat treatment and is resistant to amylase. We hypothesized that PD might have prebiotic potential affecting the microbiota composition, because it contains a non-digestible portion that may behave as dietary fiber. This study investigated the effects of PD supplementation on growth performance, gut morphology, short-chain fatty acids (SCFAs), and the bacterial community in weaned piglets receiving dietary supplementation of 0.5% PD. The piglets in the PD (treated) groups showed greater antioxidant capacity and feed efficiency (P < 0.05), as well as improved intestinal morphology in comparison with the piglets in the weaned (control) group. Gut microbiota profiles were assessed through 16S rRNA sequencing on the ileum contents and feces of early weaned piglets. Several genus-level enrichments and depletions were observed in response to PD treatment. Of note, PD supplementation decreased the relative abundance of pathogenic organisms, including Defluviicoccus and Gardnerella, while markedly increasing that of commensal bacteria (genera Psychrobacter and Prevotella), which have important roles in nutrient absorption and immune response regulation. The most notable effect in the PD treatment groups was increased production of SCFAs in the feces of PD-treated weaned piglets. Correlation analysis revealed that the improvement in SCFAs was positively correlated with the increase in SCFA-producing bacteria. Overall, this study provides a more comprehensive understanding of the effects of PD supplementation on the fecal microbial community and the modulation of SCFA production in early weaned piglets, thus indicating that PD can be used to alleviate weaning stress in piglets.

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In healthy adults, resistant maltodextrin produces a greater change in fecal bifidobacteria counts and increases stool wet weight: a double-blind, randomized, controlled crossover study

Cited by 29 publications

References 26 publications

Resistant maltodextrin intake reduces virulent metabolites in the gut environment: randomized control study in a Japanese cohort

Resistant maltodextrin intake reduces virulent metabolites in the gut environment: randomized control study in a Japanese cohort

Microbiota and Lifestyle: A Special Focus on Diet

Pyrodextrin enhances intestinal function through changing the intestinal microbiota composition and metabolism in early weaned piglets

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