In‐hospital complications after transcatheter aortic valve implantation revisited according to the valve academic research consortium definitions

Abstract

TAVI was associated with ≥1 cardiovascular and/or noncardiovascular event in 51% of the patients; new PPI was needed in another 8%, and TAVI was truly uncomplicated in 41%. Complications and need for new PPI significantly prolonged LOS.

Risk factors for bleeding complications in patients undergoing transcatheter aortic valve implantation (TAVI)

“…Moreover vascular complications were not divided according to their severity. Similarly to our analysis, other authors report that early, major bleeding complications after TAVI affect between 9% and 31% of patients [12][13][14][15][16][17]. In a single center analysis Nuis et al [12] proved that severe bleeding occured in 31% of patients and was the most frequent complication in the early post-procedural period.…”

“…Similarly to our analysis, other authors report that early, major bleeding complications after TAVI affect between 9% and 31% of patients [12][13][14][15][16][17]. In a single center analysis Nuis et al [12] proved that severe bleeding occured in 31% of patients and was the most frequent complication in the early post-procedural period. In the PARTNER study early, serious bleedings were registered in 9% to 16% of patients † Chronic hepatic disease or bilirubin > 2 × upper limit of normal, in association with aspartate aminotransferase/alanine aminotransferase/alkaline phosphatase > 3 × upper limit normal; ‡ History of anemia and/or Hgb < 12.0 g/dL on day before the procedure; § Drugs: described separately; ** According to Fisher exact test; *** referred for the procedure.…”

“…Low Euroscore or STS values in these patients demonstrate that those scales are suboptimal and for that reason construction of new scales has been proposed [10,11]. Most frequently described early, in-hospital complications of TAVI include: vascular complications, bleeding, stroke and TIA, death, the need of pacemaker implantation and acute renal failure [12][13][14][15][16][17][18]. In our study serious bleeding complications were observed in 35 (62.5%) patients.…”

“…In a meta-analysis of 12 studies analyzing prognostic influence of bleeding after TAVI Moreno et al [15] demonstrated that early bleeding and vascular complications are responsible for almost 18% of deaths in the first 30 days after the procedure. In the study on 150 patients Nuis et al [12] noted that 16% of early vascular complications were strongly related to bleeding events. Results of SOURCE registry demonstrated that vascular complications are observed in 22.9% of patients significantly increasing shortterm mortality after transapical implantation [13].…”

Incidence, Predictors and Impact of Severe Periprocedural Bleeding According to VARC-2 Criteria on 1-Year Clinical Outcomes in Patients After Transcatheter Aortic Valve Implantation

“…[16][17][18][19] These discrepancies are caused mainly by the fact that different classifications of bleeding complications were used in these studies. This is why the introduction of standardized definitions, such as VARC and VARC-2, was of vital importance as it allowed for reliable comparison across different publications.…”