In-Hospital Prognosis in Non-ST-Segment Elevation Acute Coronary Syndrome Derived Using a New Risk Score Based on Electrocardiographic Parameters Obtained at Admission

Jiménez‐Candil, Javier; Matas, José M. González; González, Ignacio Cruz; Hernández, Jesús Hernández; Martín, Ana; Pabón, Pedro; Martı́n, Francisco; Martín-Luengo, Cándido

doi:10.1016/s1885-5857(10)70170-5

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…This indicates that using the QTc interval as a prediction tool primarily for mortality and hospital admission at short and long term follow-up might not be appropriate. Evidence on the prediction power of long QTc interval is confusing with some studies providing supporting evidence (2, 21) and others providing opposing evidence (3, 6). All these studies are with serious limitations related to QT measurement and rate correction.…”

Section: Discussionmentioning

confidence: 99%

“…Delayed repolarization has also been found to predict the occurrence of several adverse cardiovascular (CV) events especially in patients with acute coronary syndrome (ACS). These events include recurrent ischemia (2), ventricular arrhythmias (3), and death (2). Long QT interval in patients with ACS probably results from increased sympathetic activity when accompanied by underlying cellular damage because of ischemia (4, 5).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and prognostic significance of long QT interval among patients with chest pain: selecting an optimum QT rate correction formula

Hasanien¹,

Drew²,

Howie-Esquivel³

et al. 2013

Journal of Electrocardiology

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Background Little is known about the prevalence and prognostic significance of long QT interval among patients with chest pain during the acute phase of suspected cardiovascular injury. Objectives Our aim was to investigate the prevalence and prognostic significance of long QT interval among patients presenting to the emergency department (ED) with chest pain using an optimum QT rate correction formula. Methods We performed secondary analysis on data obtained from the IMMEDIATE AIM trial (N, 145). Data included 24-hour 12-lead Holter electrocardiographic recordings that were stored for offline computer analysis. The QT interval was measured automatically and rate corrected using seven QTc formulas including subject specific correction. The formula with the closer to zero absolute mean QTc/RR correlation was considered the most accurate. Results Linear and logarithmic subject specific QT rate correction outperformed other QTc formulas and resulted in the closest to zero absolute mean QTc/RR correlations (mean ± SD; 0.003 ± 0.002; 0.017 ± 0.016; respectively). These two formulas produced adequate correction in 100% of study participants. Other formulas (Bazett’s, Fridericia’s, Framingham, and Study specific) resulted in inadequate correction in 47.6 to 95.2% of study participants. Using the optimum QTc formula, linear subject specific, the prevalence of long QTc interval was 14.5%. The QTc interval did not predict mortality or hospital admission at short and long term follow-up. Only the QT/RR slope predicted mortality at 7 year follow-up (odds ratio, 2.01; 95% CI, 1.02 to 3.96; p < 0.05). Conclusions Adequate QT rate correction can only be performed using subject specific correction. Long QT interval is not uncommon among patients presenting to the ED with chest pain.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence and prognostic significance of long QT interval among patients with chest pain: selecting an optimum QT rate correction formula

Hasanien¹,

Drew²,

Howie-Esquivel³

et al. 2013

Journal of Electrocardiology

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“…Treatment and MACE between the two groups were also not significantly different. 13,14,15 In this study, the average QT dispersion in the group with more severe lesion severity was 92 (75-123) msec and in the group with a lower severity, the lesion was 75 (69-107)msec. QT dispersion in both groups was found to be significantly different.…”

Section: Discussionmentioning

confidence: 46%

QT Dispersion as a Predictor of Coronary Lesion Severity in ST-Elevation Myocardial Infarction

Pinem¹,

Andra²,

Nasution³

et al. 2019

IJPTR

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Background: The prolonged QT interval and QT dispersion are ECG markers associated with the incidence of ventricular arrhythmias, and cardiovascular mortality in patients with acute myocardial infarction. This study aims to examine whether QT dispersion can be used as a predictor of the severity of lesions in STEMI patients in Haji Adam Malik General Hospital. Methods: A total of 68 patients with STEMI who undergo coronary angiography at Haji Adam Malik General Hospital since Januari 2018 until December 2018 were recruited in this cross sectional study. QT dispersion was counted from the first ECG when patient admitted at the emergency room. And then coronary angiography was done, and the Gensini score was calculated as a parameter of coronary lesion severity.Results: In the ROC curve analysis, the cutoff value of QT dispersion in the prediction of severe coronary lesion was 80.5 (AUC 0.874, 95% CI 0.778-0.970, p<0.001). The STEMI group with QT dispersion ≥ 80.5 had a higher incidence of severe coronary lesion than the group with QT dispersion < 80.5 of 34 people (89.5%) versus 4 people (10.5%). QT dispersion ≥ 80.5 is considered to predict the severity of coronary lesion with a sensitivity of 89.5%, a specificity of 83.3%, a negative predictive value (NPV) of 86.2% and a positive predictive value (PPV) of 87.1%. Conclusion: QT dispersion is a simple, very useful and an inexpensive indicator which may be used as a predictor for coronary lesion severity in patients with STEMI.

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“…Mueller et al 15 ,Lindahl et al 13 showed that the risk of in hospital and long term mortality increased with absolute level of troponin-T.According to Gadaleta et al,9 Susan et al (reported QTc>0.458) 16 , Jimenez Candil et al 17 the QTc interval was found to be an independent predictor of MACE risk in NSTEACS population.…”

Section: Discussion:-mentioning

confidence: 98%

Correlation of Corrected Qt Interval With Quantitative Cardiac Troponin-I Levels and Its Prognostic Role in Non St Elevation Myocardial Infarction.

Routray¹

2019

IJAR

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In-Hospital Prognosis in Non-ST-Segment Elevation Acute Coronary Syndrome Derived Using a New Risk Score Based on Electrocardiographic Parameters Obtained at Admission

Cited by 5 publications

References 10 publications

Prevalence and prognostic significance of long QT interval among patients with chest pain: selecting an optimum QT rate correction formula

Prevalence and prognostic significance of long QT interval among patients with chest pain: selecting an optimum QT rate correction formula

QT Dispersion as a Predictor of Coronary Lesion Severity in ST-Elevation Myocardial Infarction

Correlation of Corrected Qt Interval With Quantitative Cardiac Troponin-I Levels and Its Prognostic Role in Non St Elevation Myocardial Infarction.

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