In-hospital worsening renal function is an independent predictor of one-year mortality in patients with acute myocardial infarction

Lazaros, George; Tsiachris, Dimitris; Tousoulis, Dimitris; Patialiakas, Athanasios; Dimitriadis, Kyriakos; Roussos, Dimitris; Vergopoulos, Evangelos; Tsioufis, Costas; Vlachopoulos, Charalambos; Stefanadis, Christodoulos

doi:10.1016/j.ijcard.2010.10.024

Cited by 49 publications

(41 citation statements)

References 36 publications

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“…In our series, the incidence of WRF was not uncommon (12.9%), being comparable with those reported in patients with MI and systolic dysfunction (12.0%) [2] and in previous investigations enrolling STEMI patients [15,16].…”

supporting

confidence: 91%

ST-elevation myocardial infarction with preserved ejection fraction: The impact of worsening renal failure

Lazzeri¹,

Valente²,

Chiostri³

et al. 2012

International Journal of Cardiology

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supporting

confidence: 91%

ST-elevation myocardial infarction with preserved ejection fraction: The impact of worsening renal failure

Lazzeri¹,

Valente²,

Chiostri³

et al. 2012

International Journal of Cardiology

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“…The development of CIN after PCI is associated with poor clinical outcomes including prolonged hospitalization, increased costs, increased rates of end-stage renal failure, myocardial infarction, repeat revascularization, and short- and long-term mortality [3,4,5,6]. Furthermore, patients with acute coronary syndrome (ACS) have a 3-fold higher risk of developing CIN [7,8].…”

Section: Introductionmentioning

confidence: 99%

Association between Platelet-to-Lymphocyte Ratio and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

Demirçelik¹,

Kurtul²,

Ocek³

et al. 2015

Cardiorenal Med

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Objective: Contrast-induced nephropathy (CIN) is associated with significantly increased morbidity and mortality after percutaneous coronary intervention (PCI). Patients with acute coronary syndrome (ACS) are at higher risk of CIN. The platelet-to-lymphocyte ratio (PLR) is closely linked to inflammatory conditions. We hypothesized that PLR levels on admission can predict the development of CIN after PCI for ACS. Subjects and Methods: A total of 426 patients (mean age 63.17 ± 13.01 years, 61.2% males) with ACS undergoing PCI were enrolled in this study. Admission PLR levels were measured before PCI. Serum creatinine values were measured before and within 72 h after the administration of contrast agents. Patients were divided into 2 groups: the CIN group and the no-CIN group. CIN was defined as an increase in serum creatinine level of ≥0.5 mg/dl or 25% above baseline within 72 h after contrast administration. Results: CIN developed in 53 patients (15.9%). Baseline PLR was significantly higher in patients who developed CIN compared to those who did not (160.8 ± 29.7 and 135.1 ± 26.1, respectively; p < 0.001). Multivariate analyses found that PLR [odds ratio (OR) 3.453, 95% confidence interval (CI) 1.453-8.543; p = 0.004] and admission creatinine (OR 6.511, 95% CI 1.759-11.095; p = 0.002) were independent predictors of CIN. Conclusions: The admission PLR level is an independent predictor of the development of CIN after PCI in ACS.

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“…Numerous studies have established that the development of contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention (PCI) is strongly associated with increased rates of end-stage renal failure, myocardial infarction, repeat revascularization, and early and late mortality. [1][2][3] CI-AKI occurs even more frequently after urgent coronary revascularization in patients with ST-segment-elevation myocardial infarction (STEMI) and non-STEMI. 4 Identification of patients with STEMI who are likely to develop CI-AKI may in the future allow administration of therapeutic interventions capable of preventing CI-AKI.…”

mentioning

confidence: 99%

B-type Natriuretic Peptide and Risk of Contrast-Induced Acute Kidney Injury in Acute ST-Segment–Elevation Myocardial Infarction

Járai

Dangas²,

Huber³

et al. 2012

Circ: Cardiovascular Interventions

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Background-Contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention is associated with adverse short-and long-term outcomes. However, identification of patients at risk for CI-AKI is challenging. Using a large contemporary randomized trial database of patients with ST-segment-elevation myocardial infarction, we therefore sought to examine whether admission B-type natriuretic peptide (BNP) levels predict the development of CI-AKI. Methods and Results-A total of 979 ST-segment-elevation myocardial infarction patients enrolled in the HarmonizingOutcomes with Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial had BNP levels measured in the emergency room prior to primary percutaneous coronary intervention as part of the study protocol. CI-AKI was defined as a relative increase in serum creatinine of ≥25%, or an absolute increase of ≥0.5 mg/dL, occurring within 48 hours after contrast administration. Logistic regression analysis was used to estimate the association of admission BNP with development of CI-AKI. CI-AKI occurred in 131 patients (13.3%). Baseline BNP was a significant univariable correlate of CI-AKI (odds ratio 1.31, 95% confidence interval, 1.14-1.51; P=0.0001). After multivariable adjustment for clinical, laboratory, and angiographic variables, BNP remained a significant independent predictor of CI-AKI (1.29 [1.10, 1.51]; P<0.001). Significant net reclassification improvement was achieved by addition of BNP to the current clinical risk prediction model (net reclassification improvement=0.177; P<0.001) and to the Mehran Risk Score (net reclassification improvement=0.100; P=0.015). Conclusions-Measurement

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In-hospital worsening renal function is an independent predictor of one-year mortality in patients with acute myocardial infarction

Cited by 49 publications

References 36 publications

ST-elevation myocardial infarction with preserved ejection fraction: The impact of worsening renal failure

ST-elevation myocardial infarction with preserved ejection fraction: The impact of worsening renal failure

Association between Platelet-to-Lymphocyte Ratio and Contrast-Induced Nephropathy in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome

B-type Natriuretic Peptide and Risk of Contrast-Induced Acute Kidney Injury in Acute ST-Segment–Elevation Myocardial Infarction

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