In Japanese patients with type A gastritis with pernicious anemia the condition is very poorly associated with Helicobacter pylori infection

Saito, Makoto; Morioka, Masanobu; Wakasa, Kentaro; Izumiyama, Koh; Mori, Akio; Irie, Tatsuro; Tanaka, Masanori; Tanaka, Shinya

doi:10.1007/s10156-012-0476-6

Cited by 9 publications

(8 citation statements)

References 11 publications

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“…Although pernicious anemia affects virtually all racial and ethnic groups, it is relatively uncommon in East Asia. The results of the present study are in line with a previous Japanese report [4]. Taken together, it is suggested that the role of H. pylori in the development of pernicious anemia differs among ethnic groups, and by region.…”

supporting

confidence: 93%

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Helicobacter pylori testing in a population of Korean patients with pernicious anemia

et al. 2020

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supporting

confidence: 93%

“…In addition, restoration of hemoglobin after H. pylori eradication in patients with pernicious anemia has been observed in some Hispanic patients [3]. However, a causative role of H. pylori in pernicious anemia was not observed in other studies [4,5], such that causation remains controversial.…”

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confidence: 99%

Helicobacter pylori testing in a population of Korean patients with pernicious anemia

et al. 2020

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“…In Japan, the prevalence of AIG was assumed to be very low until about a decade ago . However, possibly on the background of a recent dramatically rapid decrease in Helicobacter pylori ( Hp ) prevalence, reports on AIG are increasing . This multicenter registry study aimed to clarify the characteristics of AIG in Japan and explore its endoscopic appearances.…”

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confidence: 99%

Multicenter study of autoimmune gastritis in Japan: Clinical and endoscopic characteristics

Terao

Suzuki

Yaita

et al. 2019

Digestive Endoscopy

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Background and Aim In Japan, the prevalence of autoimmune gastritis (AIG) is assumed to be very low. With the recent rapid decrease in Helicobacter pylori (Hp) prevalence, reports on AIG are increasing. This multicenter registry study aimed to clarify the characteristics of AIG, especially its endoscopic appearance. Methods A total of 245 patients with AIG from 11 institutions in Japan from January 2010 to October 2016 were included, and their clinical and endoscopic findings were evaluated. Results Mean age was 67.2 ± 11.4 years, and 63.7% of the participants were women. The most common approach to diagnose AIG was endoscopic examination. Repeated incorrect treatment for Hp infection, due to a false‐positive result in 13C‐urea breath test, ranked third among the basis for diagnosis of AIG. Associated gastric lesions were type 1 neuroendocrine tumor (11.4%), adenocarcinoma (9.8%), and hyperplastic polyps (21.1%). Corpus pan‐atrophy was the most common appearance (90.1%); however, remnant oxyntic mucosa was found in 31.5% of the patients (flat, localized type, 48.6%). Sticky adherent dense mucus and scattered minute whitish protrusions were also observed in approximately 30% of the patients. Despite the prevailing presumption of the antral mucosa remaining normal, 42.3% of the patients presented with various extents of atrophy, and patchy redness and circular wrinkle‐like patterns were both observed in approximately 20% of the patients. Conclusions The present study showed some prominent clinical characteristics and endoscopic findings of AIG. We believe that our study will facilitate the diagnosis of potential AIG.

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“…As AIG progresses, the secretion of intrinsic factors decreases, and pernicious anemia (PA) commonly develops as a complication because the absorption of vitamin B12 is inhibited [ 10 ]. In our patient, vitamin B12 levels remained within the normal range, and the onset of AIG was confirmed at an early stage before the onset of complications with PA.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Gastritis With Progression of Leukemic Non-Nodal Mantle Cell Lymphoma

Saito

Morioka

Izumiyama

et al. 2021

Cureus

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The pathogenesis of autoimmune gastritis (AIG) remains unclear. In addition, it is difficult to follow the process of AIG onset endoscopically. Leukemic non-nodal mantle cell lymphoma (MCL) was newly added as a subtype of MCL in the fourth revised edition of the World Health Organization (WHO) classification (2017). Here, we report a case of AIG associated with the progression of leukemic non-nodal MCL. A 74year-old woman who had been followed up in a nearby hospital for chronic B-cell lymphoproliferative disorder with no treatment for six years presented with fever and fatigue in the previous one month. The patient was admitted to our department and was diagnosed with leukemic non-nodal MCL. Positron emission tomography-computed tomography examination, which indicated no abnormalities in the six preceding years, revealed uptake in the bone marrow and spleen. Since MCL was progressing, esophagogastroduodenoscopy (EGD), which showed almost no abnormal findings in the gastric mucosa 13 preceding months, was conducted again to search for lesions involving gastrointestinal MCL. Lymphoma lesions were not found, but wide atrophic mucosal changes in the stomach were revealed mainly in the corpus, and patchy redness was also observed in the pylorus, consistent with AIG. The patient tested positive for an anti-gastric parietal cell antibody (×80), her gastrin level was significantly elevated (5,280 pg/mL), and her pepsinogen (PG) I/PG II was considerably less than 1.0 (>3.1). Although no pathological confirmation was obtained by biopsy, the patient was clinically diagnosed with AIG. In our patient, AIG was revealed to be associated with the progression of leukemic non-nodal MCL in this short period.

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In Japanese patients with type A gastritis with pernicious anemia the condition is very poorly associated with Helicobacter pylori infection

Cited by 9 publications

References 11 publications

Helicobacter pylori testing in a population of Korean patients with pernicious anemia

Helicobacter pylori testing in a population of Korean patients with pernicious anemia

Multicenter study of autoimmune gastritis in Japan: Clinical and endoscopic characteristics

Autoimmune Gastritis With Progression of Leukemic Non-Nodal Mantle Cell Lymphoma

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