In-Line Green Potentiometric Monitoring of Dissolution Behavior of Losartan Potassium Versus Pharmacopeial Methods: A Comparative Study

Ramadan, Nesrin K.; Merey, Hanan A.; Diab, Sherine S.; Moustafa, Azza A.

doi:10.1080/22297928.2021.1973908

Cited by 1 publication

(2 citation statements)

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“…[13] Terbinafine has been determined spectrophotometrically, [14,15] voltammetrically [16] and potentiometrically. [17][18][19] However, these methods require more time-consuming manipulations, expensive chemicals and mod-ern equipment. They require the expensive and hazardous use of organic solvents that pollute the environment.…”

Section: Introductionmentioning

confidence: 99%

“…Most of these techniques are based on chromatographic methods, [8] including HPLC with UV detection, [9,10] HPLC‐MS detection [11,12] and capillary zone electrophoresis [13] . Terbinafine has been determined spectrophotometrically, [14,15] voltammetrically [16] and potentiometrically [17–19] . However, these methods require more time‐consuming manipulations, expensive chemicals and modern equipment.…”

Section: Introductionmentioning

confidence: 99%

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A Novel Potentiometric Coated Wire Sensor Based on Functionalized Polymeric CaO/ZnO Nanocomposite Synthesized by Lavandula Spica Mediated Extract for Terbinafine Determination

Alterary,

Mostafa,

El‐Tohamy

et al. 2024

ChemistrySelect

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The unique properties of calcium oxide (CaO) and zinc oxide (ZnO) at the nanoscale have attracted the interest of scientists as promising electrically conductive substances for sensing purposes. The content of terbinafine hydrochloride (TRF) in pharmaceutical tablets was determined using a novel coated, wire‐functionalized CaO/ZnO nanocomposite membrane sensor biogenically produced from Lavandula spica extract. Sodium tetraphenylborate was used to prepare the active material (TRF‐TBP). The newly modified sensor gave excellent potentiometric sensitivity with the least squares regression equation EmV=(−58.88X±0.3)+log [TRF]+549.78 and covered a wide linear range (5.0×10−9–1.0×10−2 mol/L) of TRF samples. In contrast, the standard TRF‐TBP sensor wasn't as sensitive when (2.5×10−6–1.0×10−2 mol/L). TRF solutions with regression equation of (−55.728X±0.7)+log [TRF]+396.64. The appropriate pH range was 3–6. The principles of analytical methodology were applied to investigate the validity and suitability of the proposed technique. The proposed sensors were found to be suitable and efficient for the detection of TRF on tablets.

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