In-Line Phase Contrast Mammography, Phase Contrast Digital Breast Tomosynthesis, and Phase Contrast Breast Computed Tomography With a Dedicated CT Scanner and a Microfocus X-Ray Tube: Experimental Phantom Study

Mettivier, Giovanni; Franco, F. di; Sarno, Antonio; Castriconi, R.; Lillo, Francesca Di; Bliznakova, Kristina; Russo, Paolo

doi:10.1109/trpms.2020.3003380

Cited by 6 publications

(1 citation statement)

References 57 publications

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“…Moreover, Mettivier et al have recently developed a PB micro-CT scanner that uses a microfocus X-ray tube and a high-resolution flat-panel detector (with a pixel pitch of 50 µm) to improve the visibility of microcalcifications. In a study performed with a breast phantom, they reported an improvement in microcalcification and mass visibility after applying a phase retrieval technique [27]. Another advantage of the PB-CT technique is that, unlike other popular phasecontrast CT techniques, such as analyser-based [28], edgeillumination [29] and grating-based CT [23], PB-CT does not require any additional optical elements to be used for image formation.…”

Section: Introductionmentioning

confidence: 99%

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography

Aminzadeh

Arhatari

Maksimenko

et al. 2022

IEEE Trans. Med. Imaging

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Breast microcalcifications are an important primary radiological indicator of breast cancer. However, microcalcification classification and diagnosis may be still challenging for radiologists due to limitations of the standard 2D mammography technique, including spatial and contrast resolution. In this study, we propose an approach to improve the detection of microcalcifications in propagation-based phase-contrast X-ray computed tomography of breast tissues. Five fresh mastectomies containing microcalcifications were scanned at different Xray energies and radiation doses using synchrotron radiation. Both bright-field (i.e. conventional phaseretrieved images) and dark-field images were extracted from the same data sets using different image processing methods. A quantitative analysis was performed in terms of visibility and contrast-to-noise ratio of microcalcifications. The results show that while the signal-to-noise and the contrast-to-noise ratios are lower, the visibility of the microcalcifications is more than two times higher in the dark-field images compared to the bright-field images. Dark-field images have also provided more accurate information about the size and shape of the microcalcifications.

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Section: Introductionmentioning

confidence: 99%

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography

Aminzadeh

Arhatari

Maksimenko

et al. 2022

IEEE Trans. Med. Imaging

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Heat transfer capacity in millimeter size breast cancer cells analysis through thermal imaging and FDNCNN for primary stage identification

Geetha

UmaMaheswari²

2023

Biomedical Signal Processing and Control

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Virtual dosimetry study with three cone-beam breast computed tomography scanners using a fast GPU-based Monte Carlo code

Mettivier,

Lai,

Jia

et al. 2024

Phys. Med. Biol.

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Objective: To compare the dosimetric performance of three cone-beam breast computed tomography (BCT) scanners, using real-time Monte Carlo-based dose estimates obtained with the VCT-BREAST GPU-accelerated platform dedicated to virtual clinical trials (VCT) in breast imaging.Approach: A GPU-based Monte Carlo code was developed for replicating in silico the geometric, x-ray spectra and detector setups adopted respectively in two research scanners and one commercial scanner, adopting 80 kV, 60 kV and 49 kV tube voltage, respectively. Our cohort of virtual breasts included 16 anthropomorphic voxelized breast phantoms from a publicly available dataset. For each virtual patient, we simulated exams on the three scanners, up to a nominal simulated mean glandular dose of 5 mGy (primary photons launched, in the order of 10111012 per scan). Simulated 3D dose maps (recorded for skin, adipose and glandular tissues) were compared for the same phantom, on the three scanners. MC simulations were implemented on a single NVIDIA GeForce RTX 3090 graphics card. Main results: Using the spread of the dose distribution as a figure of merit, we showed that, in the investigated phantoms, the glandular dose is more uniform with less dense breasts, and it is more uniformly distributed for scans at 80 kV and 60 kV than at 49 kV. A realistic virtual study of each breast phantom was completed in about 3.0 h with less than 1% statistical uncertainty, with 109 primary photons processed in 3.6 s. Significance: We reported the first dosimetric study of the VCT-BREAST platform, a fast simulation tool for real-time virtual dosimetry and imaging trials in BCT, investigating the dose delivery performance of three clinical BCT scanners. This tool can be adopted to investigate also the effects on the 3D dose distribution produced by changes in the geometrical and spectrum characteristics of a cone-beam BCT scanner.

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In-Line Phase Contrast Mammography, Phase Contrast Digital Breast Tomosynthesis, and Phase Contrast Breast Computed Tomography With a Dedicated CT Scanner and a Microfocus X-Ray Tube: Experimental Phantom Study

Cited by 6 publications

References 57 publications

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography

Imaging Breast Microcalcifications Using Dark-Field Signal in Propagation-Based Phase-Contrast Tomography

Heat transfer capacity in millimeter size breast cancer cells analysis through thermal imaging and FDNCNN for primary stage identification

Virtual dosimetry study with three cone-beam breast computed tomography scanners using a fast GPU-based Monte Carlo code

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